Zinc Prevents Ethanol-Induced Oxidative Damage in Lingual Tissues of Rats

Bayrak, Bertan Boran; Arda-Pirincci, Pelin; Bolkent, Şehnaz; Yanardağ, Refiye

doi:10.1007/s12011-021-02682-6

Cited by 2 publications

(2 citation statements)

References 54 publications

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“…e 10-fold higher dose of zinc led to cell damage and disorders of the repair functions [44]. Moreover, Zn sulphate has therapeutic effects on the cell oxidative damage by the increase of MT synthesis that was shown on the tongue tissues of rats [45].…”

Section: Role Of Zn In the Regulation Of Metallothionein Expressionmentioning

confidence: 98%

Metallothioneins in Inflammatory Bowel Diseases: Importance in Pathogenesis and Potential Therapy Target

Socha-Banasiak

Sputa-Grzegrzółka

Grzegrzółka

et al. 2021

Canadian Journal of Gastroenterology and Hepatology

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Immunological disorders, increased oxidative stress, and damage to the epithelial barrier play an important role in the pathogenesis of inflammatory bowel diseases (IBDs). In the treatment of patients with Crohn’s disease (CD) and ulcerative colitis (UC), it is increasingly common to use biological drugs that selectively affect individual components of the inflammatory cascade. However, administering the medicines currently available does not always result in obtaining and maintaining remission, and it may also lead to the development of resistance to a given agent over time. Metallothioneins (MTs) belong to the group of low molecular weight proteins, which, among others, regulate the inflammation and homeostasis of heavy metals as well as participating in the regulation of the intensity of oxidative stress. The results of the studies conducted so far do not clearly indicate the role of MTs in the process of inflammation in patients with IBD. However, there are reports that suggest the possibility of using MTs as a potential target in the treatment of this group of patients.

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Section: Role Of Zn In the Regulation Of Metallothionein Expressionmentioning

confidence: 98%

Metallothioneins in Inflammatory Bowel Diseases: Importance in Pathogenesis and Potential Therapy Target

Socha-Banasiak

Sputa-Grzegrzółka

Grzegrzółka

et al. 2021

Canadian Journal of Gastroenterology and Hepatology

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“…Based on the report from the World Health Organization in 2018, the death rates caused by alcohol consumption correspond to 5.1% of all deaths worldwide. In particular, excessive EtOH intake can cause many hepatocytes damage and diseases such as fatty liver, chronic hepatitis, alcoholic hepatitis, hepatic fibrosis, hepatic cirrhosis, as well as liver cancer [6][7][8][9]. Thus, protecting the body against EtOH-induced damage has taken the researcher's attention.…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Sargassum fusiforme Fucoidan against Ethanol-Induced Oxidative Damage in In Vitro and In Vivo Models

Wang

Yang

et al. 2023

Polymers

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Our previous studies have evaluated the bioactivities of a fucoidan isolated from Sargassum fusiforme (SF-F). To further investigate the health benefit of SF-F, in the present study, the protective effect of SF-F against ethanol (EtOH)-induced oxidative damage has been evaluated in in vitro and in vivo models. SF-F effectively improved the viability of EtOH-treated Chang liver cells by suppressing apoptosis. In addition, the in vivo test results indicate that SF-F significantly and dose-dependently increased the survival rate of zebrafish treated with EtOH. Further research results show that this action works through decreasing cell death via reduced lipid peroxidation by scavenging intracellular reactive oxygen species in EtOH-stimulated zebrafish. These results indicate that SF-F effectively protected Chang liver cells and zebrafish against EtOH-induced oxidative damage and suggest the potential of SF-F to be used as an ingredient in the functional food industry.

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Zinc Prevents Ethanol-Induced Oxidative Damage in Lingual Tissues of Rats

Cited by 2 publications

References 54 publications

Metallothioneins in Inflammatory Bowel Diseases: Importance in Pathogenesis and Potential Therapy Target

Metallothioneins in Inflammatory Bowel Diseases: Importance in Pathogenesis and Potential Therapy Target

Protective Effect of Sargassum fusiforme Fucoidan against Ethanol-Induced Oxidative Damage in In Vitro and In Vivo Models

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