Zinc oxide spiky nanoparticles: A promising nanomaterial for killing tumor cells

Dang, Zechun; Sun, Jian; Fan, Jiaqi; Li, Jinqi; Li, Xinlei; Chen, Tongsheng

doi:10.1016/j.msec.2021.112071

Cited by 22 publications

(18 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The average publication years for these terms, from 2019.8 to 2020.2, highlight the contemporary thrust in unearthing ZnO NPs' anticancer potential. [43][44][45][50][51][52][53][54][55][56][57][58][59] In conclusion, each cluster within the VOSviewer network analysis embodies a distinctive research dimension concerning ZnO NPs for drug delivery. Cluster 1 tackles diabetes-related complications and synergistic effects; Cluster 2 explores viral infections and material characterization; Cluster 3 delves into antimicrobial applications; Cluster 4 accentuates wound healing and tissue regeneration; and Cluster 5 unravels the potential anticancer prowess of ZnO NPs.…”

Section: Contemporary Topics Per Clustermentioning

confidence: 99%

“…[42][43][44][45][46][47][48][49] This quality positions ZnO NPs as auspicious candidates for targeted cancer therapies, potentially mitigating the adverse effects frequently associated with conventional chemotherapy and radiation treatments. [50][51][52][53][54][55][56][57] In drug uptake, the mesoporous configuration inherent to ZnO nanostructures leads to a substantial augmentation in surface area-to-volume ratio, thereby facilitating enhanced drug encapsulation within the nanosystems. [45] A mechanism exploited for the accelerated proliferation of cancer cells involves overexpressing receptors for vitamins on the cell membrane.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Data Mining Study of Zinc Oxide Nanostructures Utilization in Drug Delivery Nanosystems

Valladão,

da Silva,

Souza

2024

Macromolecular Symposia

View full text Add to dashboard Cite

The present investigation offers a thorough bibliometric exploration spotlighting the pivotal utilization of zinc oxide nanostructures, encompassing both zero‐dimensional (0D) nanoparticles and one‐dimensional (1D) nanostructures, within the realm of nanotechnology‐driven drug delivery systems. This analysis particularly illuminates the distinctive potential of these nanostructures in the cancer therapy context, not merely as carriers and deliverers of pharmaceutical agents, but as entities capable of selectively inducing apoptosis in cancer cells through the orchestrated generation of reactive oxygen species (ROS). Recent research endeavors notably underscore the application prospects of ZnO nanostructures in domains like DNA cleavage, bioimaging, and agricultural defense mechanisms. Moreover, the study elucidates the pronounced enhancement in solubility and biocompatibility that these nanostructures bring about when harmoniously integrated into polymeric nanocomposites. Concomitantly, the involvement of polymers in this symbiotic system is unveiled, wherein they play a multifaceted role in dictating release selectivity, thereby facilitating targeted and efficacious interactions with tissues. Functionally engineered polymeric nanocomposites emerge as promising candidates for targeted delivery modalities in cancer treatment, demonstrating an affinity for specific cell receptors and exhibiting enhanced cellular uptake within the size range of 100–200 nm. The study unearths robust associations among pivotal research terminologies through an exhaustive analysis of Link Strength Between Items (LSBI), culminating in the presentation of a cogent map delineating the evolving trends and forthcoming trajectories in this dynamic domain. In summation, this all‐encompassing bibliometric inquiry serves as a poignant testament to the prodigious potential of zinc oxide nanostructures in the realm of forthcoming nanotechnology‐driven drug delivery paradigms.

show abstract

Section: Contemporary Topics Per Clustermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Data Mining Study of Zinc Oxide Nanostructures Utilization in Drug Delivery Nanosystems

Valladão,

da Silva,

Souza

2024

Macromolecular Symposia

View full text Add to dashboard Cite

show abstract

“…NMs are novel functional materials with unique physical and chemical characteristics, outperforming their bulk counterparts. Due to their small size, NMs may pass through biological barriers to interact with key substances inside the cell, making them an ideal platform for biomedicine [ 9 , 10 ]. Among the various types of NMs, piezoelectric nanostructures feature the conversion of mechanical energy to electrical energy via the piezoelectric effect.…”

Section: Introductionmentioning

confidence: 99%

Emerging Advancements in Piezoelectric Nanomaterials for Dynamic Tumor Therapy

Shi

et al. 2023

Molecules

View full text Add to dashboard Cite

Cancer is one of the deadliest diseases, having spurred researchers to explore effective therapeutic strategies for several centuries. Although efficacious, conventional chemotherapy usually introduces various side effects, such as cytotoxicity or multi−drug resistance. In recent decades, nanomaterials, possessing unique physical and chemical properties, have been used for the treatment of a wide range of cancers. Dynamic therapies, which can kill target cells using reactive oxygen species (ROS), are promising for tumor treatment, as they overcome the drawbacks of chemotherapy methods. Piezoelectric nanomaterials, featuring a unique property to convert ultrasound vibration energy into electrical energy, have also attracted increasing attention in biomedical research, as the piezoelectric effect can drive chemical reactions to generate ROS, leading to the newly emerging technique of ultrasound−driven tumor therapy. Piezoelectric materials are expected to bring a better solution for efficient and safe cancer treatment, as well as patient pain relief. In this review article, we highlight the most recent achievements of piezoelectric biomaterials for tumor therapy, including the mechanism of piezoelectric catalysis, conventional piezoelectric materials, modified piezoelectric materials and multifunctional piezoelectric materials for tumor treatment.

show abstract

“…11,12 However, its high toxicity, low solubility and poor bioavailability hinder the clinical applications. 13,14 Nano-preparations made from inorganic compounds such as copper oxide, 15 zinc oxide 16 and realgar, 17 have already been researched the antineoplastic activities.…”

Section: Introductionmentioning

confidence: 99%

Acid ground nano‐realgar processed product inhibits breast cancer by inducing mitophagy via the p53/BNIP3/NIX pathway

Fang,

Zou,

Gong

et al. 2023

J Cellular Molecular Medi

View full text Add to dashboard Cite

Breast cancer is a highly prevalent malignancy with the first morbidity and the primary reason for female cancer‐related deaths worldwide. Acid ground nano‐realgar processed product (NRPP) could inhibit breast cancer cell proliferation and induce autophagy in our previous research; however, the underlying mechanisms are still unclear. Therefore, this research aimed to verify whether NRPP induces breast cancer mitophagy and explore the mitophagy‐mediated mechanism. Primarily, rhodamine‐123 assay and transmission electron microscopy were applied to detect mitochondrial membrane potential (MMP) and ultrastructural changes in the MDA‐MB‐435S cells, respectively. Mito‐Tracker Green/Lyso‐Tracker Red staining, western blot, immunofluorescence and RT‐PCR were used to explore molecular mechanisms of NRPP‐induced mitophagy in vitro. MDA‐MB‐435S breast cancer xenograft models were established to assess the activity and mechanisms of NRPP in vivo. Our results showed that NRPP decreased MMP and increased autophagosome numbers in MDA‐MB‐435S cells and activated mitophagy. Furthermore, mitophagy was consolidated because mitochondria and lysosomes colocalized phenomenology were observed, and the expression of LC3II/I and COXIV was upregulated. Additionally, we found the p53/BNIP3/NIX pathway was activated. Finally, NRPP inhibited tumour growth and downregulated the levels of TNF‐α, IL‐1β and IL‐6. Necrosis, damaged mitochondria and autophagosomes were observed in xenograft tumour cells, and proteins and mRNA levels of LC3, p53, BNIP3 and NIX were increased. Overall, NRPP inhibited MDA‐MB‐435S cell proliferation and tumour growth by inducing mitophagy via the p53/BNIP3/NIX pathway. Thus, NRPP is a promising candidate for breast cancer treatment.

show abstract

Zinc oxide spiky nanoparticles: A promising nanomaterial for killing tumor cells

Cited by 22 publications

References 35 publications

A Data Mining Study of Zinc Oxide Nanostructures Utilization in Drug Delivery Nanosystems

A Data Mining Study of Zinc Oxide Nanostructures Utilization in Drug Delivery Nanosystems

Emerging Advancements in Piezoelectric Nanomaterials for Dynamic Tumor Therapy

Acid ground nano‐realgar processed product inhibits breast cancer by inducing mitophagy via the p53/BNIP3/NIX pathway

Contact Info

Product

Resources

About