Zinc Oxide Nanoparticles with Mangiferin: Optical Properties, In Vitro Release Studies, and Antibacterial Activity

Toxicity of Hybrid Particles (PLGA-ZnO) Loaded with Lupeol and Mangiferina: Ex Vivo Model of Peripheral Cells

“…Other studies show that the use of PLGA does not sample damage in erythrocytes at concentrations lower than 200 μg/ mL; 22 however, the use of materials such as ZnO promotes ROS production and consequently eryptosis. 44 According to previous results already mentioned, all the particles have sizes smaller than 300 nm 16,23 and are gastroresistant for 1.5 h (encapsulated with PLGA) 16,22 and 3 h (ZnO); 23,17 for this reason the continuity of this study allows the identificacion materials applicable to the food industry or even to phytopharmacy for polymers such as PLGA. In addition, lupeol is a phytochemical that has been widely studied for its biological properties, 18,20 but its toxicity is concentration-dependent, so encapsulation is an alternative for the development of substances with a potential nutraceutical effect.…”

“…Two types of ZnO nanoparticles were synthesized by the sol–gel process loaded with mangiferin; , 10 mg of MG/g zinc acetate was used. 2 g of PEG and 10 g of precursor were added, homogenized in 140 mL of ethanol using a magnetic stirrer, and pH was adjusted to 7 with NH 4 OH [1 M], heated with reflux at 70 °C for 3 h, the gel was dried for 24 h at 70 °C and ground to a fine powder, annealed at 500 °C for 5 h under a controlled atmosphere with a heat ramp of 1 °C/min and finally ground again in a mortar to obtain the fine powder called ZnO A -MG. Once these particles were obtained, encapsulation was carried out by the emulsion and solvent evaporation method to obtain hybrid particles (PLGA LP /ZnO A -MG); in the continuous phase 10 mg of PLGA and 1.2 mg of lupeol in acetone were added.…”

“…Before this assay, the treatments were characterized by particle size, , morphological evaluation, ,, release profile, and biological evaluation. ,, …”

“…The incorporation of the mixture of bioactive compounds in encapsulation systems such as mangiferin, a yellow polyphenol that has the C-glycosyl xanthone structure, is widely present in different edible sources such as mangos and has several biological activities, so it has been widely invested in showing antioxidant, anti-inflammatory, antidiabetic, anticancer, analgesic, and immunomodulatory properties . Studies we have published describe that PLGA-encapsulated mangiferin potentiates its antitopoisomerase and cyclooxygenase activity due to its release profile compared to the standard phytochemical; in other studies, we wrote the characteristics of mangiferin-loaded ZnO nanoparticles, showing higher encapsulation efficiency of the bioactivity, which translates into higher biological activity …”

“…15 Studies we have published describe that PLGA-encapsulated mangiferin potentiates its antitopoisomerase and cyclooxygenase activity due to its release profile compared to the standard phytochemical; 16 in other studies, we wrote the characteristics of mangiferin-loaded ZnO nanoparticles, showing higher encapsulation efficiency of the bioactivity, which translates into higher biological activity. 17 Another phytochemical is lupeol, a pentacyclic triterpene of the lupane type, found mainly in common fruit plants such as olives, mangos, and figs, among others; 18 this compound has also been associated as an anti-inflammatory, 19,20 antiarthritic, and antimutagenic. 21 Therefore, in recent years, they have been molecules of interest for the development of nanoparticles.…”