Zinc oxide nanoparticles induce toxicity in diffuse large B-cell lymphoma cell line U2932 via activating PINK1/Parkin-mediated mitophagy.

Li, Zonghong; Yin, Xuewei; Lyu, Chunyi; Wang, Teng; Wang, Wenhao; Zhang, Jiachen; Wang, Zhenzhen; Chen, Han; Zhang, Ruixue; Guo, Dadong; Xu, Ruirong

doi:10.1016/j.biopha.2023.114988

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Biomedicine & Pharmacotherapy

2023

DOI: 10.1016/j.biopha.2023.114988

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Zinc oxide nanoparticles induce toxicity in diffuse large B-cell lymphoma cell line U2932 via activating PINK1/Parkin-mediated mitophagy.

Zonghong Li

Xuewei Yin

Chunyi Lyu

et al.

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2024

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Cited by 3 publications

References 68 publications

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Mitophagy and its regulatory mechanisms in the biological effects of nanomaterials

Zhang,

Yang,

Guo

et al. 2024

J of Applied Toxicology

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Mitophagy is a selective cellular process critical for the removal of damaged mitochondria. It is essential in regulating mitochondrial number, ensuring mitochondrial functionality, and maintaining cellular equilibrium, ultimately influencing cell destiny. Numerous pathologies, such as neurodegenerative diseases, cardiovascular disorders, cancers, and various other conditions, are associated with mitochondrial dysfunctions. Thus, a detailed exploration of the regulatory mechanisms of mitophagy is pivotal for enhancing our understanding and for the discovery of novel preventive and therapeutic options for these diseases. Nanomaterials have become integral in biomedicine and various other sectors, offering advanced solutions for medical uses including biological imaging, drug delivery, and disease diagnostics and therapy. Mitophagy is vital in managing the cellular effects elicited by nanomaterials. This review provides a comprehensive analysis of the molecular mechanisms underpinning mitophagy, underscoring its significant influence on the biological responses of cells to nanomaterials. Nanoparticles can initiate mitophagy via various pathways, among which the PINK1‐Parkin pathway is critical for cellular defense against nanomaterial‐induced damage by promoting mitophagy. The role of mitophagy in biological effects was induced by nanomaterials, which are associated with alterations in Ca2+ levels, the production of reactive oxygen species, endoplasmic reticulum stress, and lysosomal damage.

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Mitophagy and its regulatory mechanisms in the biological effects of nanomaterials

Zhang,

Yang,

Guo

et al. 2024

J of Applied Toxicology

View full text Add to dashboard Cite

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Protective effect of zinc oxide nanoparticles synthesized using Cassia alata for DSS-induced ulcerative colitis in mice model

Govindarasu,

Vaiyapuri,

Kim

2024

Bioprocess Biosyst Eng

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ROS-mediated NRF2/p-ERK1/2 signaling-involved mitophagy contributes to macrophages activation induced by CdTe quantum dots

Liu,

Liang,

Wei

et al. 2024

Toxicology

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Zinc oxide nanoparticles induce toxicity in diffuse large B-cell lymphoma cell line U2932 via activating PINK1/Parkin-mediated mitophagy.

Cited by 3 publications

References 68 publications

Mitophagy and its regulatory mechanisms in the biological effects of nanomaterials

Mitophagy and its regulatory mechanisms in the biological effects of nanomaterials

Protective effect of zinc oxide nanoparticles synthesized using Cassia alata for DSS-induced ulcerative colitis in mice model

ROS-mediated NRF2/p-ERK1/2 signaling-involved mitophagy contributes to macrophages activation induced by CdTe quantum dots

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