Zinc oxide nanoparticles induce eosinophilic airway inflammation in mice

Huang, Kuo-Liang; Lee, Yi-Hsin; Chen, Hau-Inh; Liao, Huang-Shen; Chiang, Bor‐Luen; Cheng, Tsun‐Jen

doi:10.1016/j.jhazmat.2015.05.023

Cited by 57 publications

(40 citation statements)

References 50 publications

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“…Hematite NPs have been observed to decrease total immune cell numbers in the lungs and lymph nodes of OVA sensitized mice, an effect which the authors speculate could be due to the acidic nature of the inflammatory environment causing Fe ion release from the nanoparticles, increasing ROS production (Ban et al, 2013). Zinc NPs are well known for their toxicity, and ZnO NPs have been tested in the OVA asthma models and were found to increase BALF cell counts and serum IgE levels over OVA alone, an effect that was determined to be Zn ion-independent (Huang et al, 2015). Copper oxide NPs have also been shown to exacerbate asthma: in an OVA model they exacerbate numerous endpoints including AHR, inflammatory cell counts, cytokines, IgE and ROS .…”

Section: Iron Zinc Copper and Nickel Nanoparticlesmentioning

confidence: 97%

An overview on nanoparticle based approach for treatment and management of asthmatic disorder

Mahobia¹,

Namdeo²

2019

Adv Pharm J

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consists of nano particle, dendrimers, micelles, drug, Conjugate, metallic nano-particle etc (Figure 1). Application of NanotechnologyThe different fields that find potential application of nanotechnology are as health and medicine, electronics, energy and environment, agriculture, etc. Nanotechnology in health and medicineWith the help of nano medicine early detection and prevention, improved diagnosis, proper treatment and AbstractAccording to the World Health Organization, Asthma is the fastest-growing disease in the world alongside HIV/AIDS, and its socioeconomic burden exceeds the sum of HIV/AIDS and tuberculosis. Its high disability and mortality rates have become serious social and public health concerns. Asthma is a heterogeneous disease in which genetic polymorphisms interact with the environmental factors. While no specific treatment has been available for asthma due to its complex pathogenesis, the advances in nanotechnology have brought new hope for the early diagnosis, treatment, and prevention of asthma. Nanotechnology can achieve targeted delivery of drugs or genes, reduce toxic effects, and improve drug bioavailability. The nano-modifications of drugs and the development of new nano-drugs have become new research directions. Studies have demonstrated the safety and effectiveness of nanocarriers. However, many challenges still need to be overcome before nanotherapy can be applied in clinical practice. In this article we review the new research highlights in this area, with an attempt to explore the great potential and feasibility of nanotechnology in treating asthma.

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Section: Iron Zinc Copper and Nickel Nanoparticlesmentioning

confidence: 97%

An overview on nanoparticle based approach for treatment and management of asthmatic disorder

Mahobia¹,

Namdeo²

2019

Adv Pharm J

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“…Hematite NPs have been observed to decrease total immune cell numbers in the lungs and lymph nodes of OVA sensitized mice, an effect which the authors speculate could be due to the acidic nature of the inflammatory environment causing Fe ion release from the nanoparticles, increasing ROS production [39]. Zinc NPs are well known for their toxicity, and ZnO NPs have been tested in the OVA asthma models and were found to increase BALF cell counts and serum IgE levels over OVA alone, an effect that was determined to be Zn ion-independent [40]. Copper oxide NPs have also been shown to exacerbate asthma: in an OVA model they exacerbate numerous endpoints including AHR, inflammatory cell counts, cytokines, IgE and ROS [41].…”

Section: Enm-induced Asthma Exacerbationsmentioning

confidence: 99%

“…Zn, Ni and Cu NPs are able to recruit eosinophils to the lungs [40, 65, 66]. In epithelial cells in vitro both Zn and Cu NPs increased IL-8 secretion, and Cu NPs alone increased NF-κB activity; these effects were found to be ion-dependent [65].…”

Section: Enms As a Direct Cause Of Allergic Airway Diseasementioning

confidence: 99%

“…This study, however, also showed Zn NP recruitment of eosinophils to the lung to be ion-independent [65]. Zn NPs also increase BALF levels of the T H 2 cytokines IL-4, IL-13 and IL-5 [40]. In addition to eosinophil recruitment, Cu NPs also induce IL-6, IL-8 and Muc5ac production in bronchial epithelial cells in vitro , the latter of which is MAPK-dependent [67].…”

Section: Enms As a Direct Cause Of Allergic Airway Diseasementioning

confidence: 99%

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The Toxicology of Engineered Nanomaterials in Asthma

Ihrie

Bonner

2018

Curr Envir Health Rpt

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Recent studies highlight the ability of metal nanoparticles (NPs) and carbon nanotubes (CNTs) to not only exacerbate pre-existing asthma in animal models but also initiate allergic airway disease directly. CNTs alone are shown to cause airway mucus production, elevated serum IgE levels, and increased T2 cytokine levels, all key indicators of asthma. The ability of ENMs to modulate the immune response in asthma varies depending on their physicochemical properties and exposure timing. CNTs consistently exacerbate asthma, as do Ni and TiO NPs, whereas some NPs like Au attenuate asthma. Evidence is strong that ENMs can contribute to allergic airway disease; however, more work is required to determine their mechanisms, and more epidemiological studies are needed to validate results from animal models.

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“…Several studies have investigated the toxicological effect of ZnONP in vivo [153][154][155][156]. The intra-tracheal instillation of ZnONP in mice induced acute lung inflammation and lung injury with a significant increase in the LDH level detected in bronchial alveolar lavage fluids (BALF) [157,158].…”

Section: In Vivo Znonp Toxicitymentioning

confidence: 99%

A distinct pattern of sterile inflammation induced by zinc oxide nanowires.

Alghsham¹

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Zinc oxide nanoparticles induce eosinophilic airway inflammation in mice

Cited by 57 publications

References 50 publications

An overview on nanoparticle based approach for treatment and management of asthmatic disorder

An overview on nanoparticle based approach for treatment and management of asthmatic disorder

The Toxicology of Engineered Nanomaterials in Asthma

A distinct pattern of sterile inflammation induced by zinc oxide nanowires.

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