Zinc oxide nanoparticles for bioimaging and drug delivery

Sahoo, Rakesh Kumar; Rani, Sarita; Kumar, Vinay; Gupta, Umesh

doi:10.1016/b978-0-12-818900-9.00021-8

Cited by 9 publications

(5 citation statements)

References 145 publications

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“…Accordingly, ZnO nanoparticles have been investigated as a drug delivery vehicle and have been approved by the FDA, given their biocompatibility and nontoxic nature. These nanostructures exhibit antibacterial and anticancer activity linked to their capability to generate reactive oxygen species (ROS) [ 186 ]. Drug-loaded ZnO NPs can penetrate the cells of the targeted tissue through various endocytic pathways; therefore, they have emerged as an effective nanocarrier for drug delivery.…”

Section: Drug Delivery Systemsmentioning

confidence: 99%

Drug Delivery Systems in Regenerative Medicine: An Updated Review

et al. 2023

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Modern drug discovery methods led to evolving new agents with significant therapeutic potential. However, their properties, such as solubility and administration-related challenges, may hinder their benefits. Moreover, advances in biotechnology resulted in the development of a new generation of molecules with a short half-life that necessitates frequent administration. In this context, controlled release systems are required to enhance treatment efficacy and improve patient compliance. Innovative drug delivery systems are promising tools that protect therapeutic proteins and peptides against proteolytic degradation where controlled delivery is achievable. The present review provides an overview of different approaches used for drug delivery.

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Section: Drug Delivery Systemsmentioning

confidence: 99%

Drug Delivery Systems in Regenerative Medicine: An Updated Review

et al. 2023

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“…19 For instance, ZnO is used for the treatment of various types of cancer diseases 20 and ZnO nanoparticles are utilized in bioimaging because of their high stability and inherent photoluminescence properties. 21 The ZnO surface structure as well as photoluminescence can be modified by hydrogen plasma. 22 ZnO exhibits also a high adsorption capability and selectivity for photocatalytic dye removal 23 and wastewater treatment in general.…”

Section: Introductionmentioning

confidence: 99%

“…Zinc oxide (ZnO) and other metal oxide nanomaterials represent a versatile platforms for biomedical applications and therapeutic intervention. − ZnO nanostructures are widely used for drug delivery and theranostic applications . For instance, ZnO is used for the treatment of various types of cancer diseases and ZnO nanoparticles are utilized in bioimaging because of their high stability and inherent photoluminescence properties . The ZnO surface structure as well as photoluminescence can be modified by hydrogen plasma .…”

Section: Introductionmentioning

confidence: 99%

Polarization Controlled Assembly of Ultrathin Thiorphan Nanostructures on ZnO Surface Facets

2023

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Despite the importance of thiorphan as a small molecule with vital biological roles, its interactions with zinc oxide (ZnO) nanomaterials that are prospective in drug delivery and theranostic applications have not yet been sufficiently explored.Here the impact of surface polarity of different ZnO facets on thiorphan adsorption is studied both experimentally by atomic force microscopy (AFM) and angle resolved X-ray photoelectron spectroscopy (XPS) and theoretically by force field molecular dynamics (FFMD) and density functional tight binding simulations (DFTB). Polar ZnO surfaces cause the formation of thiorphan nanodots, where the size of the nanodots depends on the direction of dipoles: small (4 nm) nanodots are formed on Znface ZnO, while large (25 nm) nanodots are formed on O-face ZnO. Nonpolar ZnO surfaces cause self-assembly into layered nanoislands with characteristic 4 nm layer thickness, which subsequently merge into rigid nanolayers. The self-assembly is shown to be controlled solely by the effect of surface dipole electric field orientation and magnitude, whereas effects of surface chemistry or solution are negligible. The results thus also show a way for controlling the assembly of thiorphan and other molecular nanomaterials for diverse applications.

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“…Nanocrystals (NCs) are attractive image contrast agents − and drug delivery vehicles − due to their high photostability and diverse surface functionality. ,− , NC surfaces can be tailored with surface capping ligands that serve multiple purposes. First, the ligand chemistry and structure determine how the NC interacts with the environment, such as the ability to target and bind specific biomolecules via receptors. − Second, ligand properties determine the colloidal stability of NCs. ,− Understanding the ligand shell morphology is important because it partially determines the long-term colloidal stability and chemical or structural integrity of the NC core.…”

Section: Introductionmentioning

confidence: 99%

Characterizing the Ligand Shell Morphology of PEG-Coated ZnO Nanocrystals Using FRET Spectroscopy

Lustig,

Buz,

Mulvey

et al. 2023

J. Phys. Chem. B

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Poly(ethylene glycol) (PEG) ligands can inhibit proteins and other biomolecules from adhering to underlying surfaces, making them excellent surface ligands for nanocrystal (NC)-based drug carriers. Quantifying the PEG ligand shell morphology is important because its structure determines the permeability of biomolecules through the shell to the NC surface. However, few in situ analytical tools can reveal whether the PEG ligands form either an impenetrable barrier or a porous coating surrounding the NC. Here, we present a Forster resonance energy transfer (FRET) spectroscopy-based approach that can assess the permeability of molecules through PEG-coated ZnO NCs. In this approach, ZnO NCs serve as FRET donors, and freely diffusing molecules in the bulk solution are FRET acceptors. We synthesized a series of variable chain length PEG-silane-coated ZnO NCs such that the longest chain length ligands far exceed the Forster radius (R 0 ), where the energy transfer (EnT) efficiency is 50%. We quantified the EnT efficiency as a function of the ligand chain length using time-resolved photoluminescence lifetime (TRPL) spectroscopy within the framework of FRET theory. Unexpectedly, the longest PEG-silane ligand showed equivalent EnT efficiency as that of bare, hydroxyl-passivated ZnO NCs. These results indicate that the "rigid shell" model fails and the PEG ligand shell morphology is more likely porous or in a patchy "mushroom state", consistent with transmission electron microscopy data. While the spectroscopic measurements and data analysis procedures discussed herein cannot directly visualize the ligand shell morphology in real space, the in situ spectroscopy approach can provide researchers with valuable information regarding the permeability of species through the ligand shell under practical biological conditions.

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Zinc oxide nanoparticles for bioimaging and drug delivery

Cited by 9 publications

References 145 publications

Drug Delivery Systems in Regenerative Medicine: An Updated Review

Drug Delivery Systems in Regenerative Medicine: An Updated Review

Polarization Controlled Assembly of Ultrathin Thiorphan Nanostructures on ZnO Surface Facets

Characterizing the Ligand Shell Morphology of PEG-Coated ZnO Nanocrystals Using FRET Spectroscopy

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