Zinc oxide nanoparticles: an excellent biomaterial for bioengineering applications

Ringu, Togam; Ghosh, Sampad; Das, Abinash; Pramanik, Nabakumar

doi:10.1007/s42247-022-00402-x

Cited by 15 publications

(8 citation statements)

References 108 publications

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“…coli, with S. aureus being more sensitive. , The differences in the susceptibility of microorganisms to antibacterial agents such as ZnO nanoparticles can be quite pronounced, as shown by the higher susceptibility of E. faecalis compared to E.…”

Section: Resultsmentioning

confidence: 99%

Therapeutic Potential of Sol–Gel ZnO Nanocrystals: Anticancer, Antioxidant, and Antimicrobial Tri-Action

Eren,

Gunduz,

Kaymak

et al. 2024

ACS Omega

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Zinc oxide nanocrystals (ZnO NCs) hold great promise in nanomedicine with fascinating multifunctional properties. We investigated the therapeutic potential of sol−gel synthesized ZnO NCs with crystal sizes of 52.65 and 25.11 nm, focusing on their anticancer effects on HepG2 and HT29 cells, antioxidant properties, and antimicrobial activity. Both samples displayed a hexagonal wurtzite ZnO structure, wherein the crystal sizes diminished with lower calcination temperatures according to X-ray diffraction. The scanning electron microscopy analysis revealed that lowering the calcination temperature resulted in a decrease in the grain size of the ZnO NCs, as expected. This reduction in grain size combined with a decrease in crystal size resulted in a significant 40% reduction in the reflectance of the ZnO NCs in UV−vis−NIR spectroscopy. It was also observed that the ZnO NCs calcined at higher temperatures exhibited larger particle sizes with a reduced surface area mean of 69.30 μm and a stable negative zeta potential of −11.2 mV. In contrast, the ZnO NCs calcined at lower temperatures exhibited a larger surface area mean of 34.56 μm and a positive zeta potential of +10 mV. In both cell lines, the cytotoxic potential was found to be higher in HepG2 cells. Specifically, when ZnO nanocrystals (NCs) with a crystal size of 52.65 nm were used, the lowest cell viability was observed at a concentration of 5.74 μg/mL. Based on oxidative stress index values, a lower crystal size of ZnO NCs displayed greater effectiveness in HT29 cells, while a higher crystal size of ZnO NCs had pronounced effects in HepG2 cells. Moreover, both ZnO NCs exhibited significant antimicrobial activity against Gram-positive bacteria (Enterococcus faecalis and Staphylococcus aureus) and Candida parapsilopsis fungus. These findings emphasize sol−gel ZnO NCs' potential as versatile agents in nanomedicine, spurring research on targeted cancer therapies and antimicrobial innovations.

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Section: Resultsmentioning

confidence: 99%

Therapeutic Potential of Sol–Gel ZnO Nanocrystals: Anticancer, Antioxidant, and Antimicrobial Tri-Action

Eren,

Gunduz,

Kaymak

et al. 2024

ACS Omega

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“…Therefore, the mass drop curve is clearly obtained by the organic degradation/decompositions while the ZnONPs remained stable with their lattice orientations, and hence, the mass drop does not start at 100% [53]. Figure 8b shows the DSC curve of the synthesized ZnONPs, which revealed endothermic peaks at around 285 • C. The broad peak at around 285 • C is probably due to the loss of chemically adsorbed volatile organic molecules and the formation of ZnONPs [54,55].…”

Section: Thermogravimetric Analysis (Tga) and Dsc Studies Of Znonpsmentioning

confidence: 98%

“…Figure 8b shows the DSC curve of the synthesized ZnONPs, which revealed endothermic peaks at around 285 °C. The broad peak at around 285 °C is probably due to the loss of chemically adsorbed volatile organic molecules and the formation of ZnONPs [54,55].…”

Section: Thermogravimetric Analysis (Tga) and Dsc Studies Of Znonpsmentioning

confidence: 99%

Scallion Peel Mediated Synthesis of Zinc Oxide Nanoparticles and Their Applications as Nano fertilizer and Photocatalyst for Removal of Organic Pollutants from Wastewater

Soltani

Gacem

Choudhary

et al. 2023

Water

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Nanotechnology and nanomaterials have gained much attention in recent years due to their remarkable features. Among nanoparticles, photocatalytic material, such as zinc oxide, have shown tremendous applications in each and every field of science. In the present research, investigators have synthesized zinc oxide nanoparticles (ZnONPs) using Scallion’s peel extract. ZnONPs were both spherical and rod-shaped, where the size for spherical particles was 40–100 nm and rod-shaped, particles size was more than 200 nm as confirmed by microscopic techniques. The typical trademark bands of ZnONPs at 400–800 cm−1 were revealed by infrared spectroscopy, which also showed bands of carbonyl and hydroxyl groups. The hydrodynamic size by particle size analyzer (PSA) shows a size near about 200 nm in diameter. Furthermore, the synthesized ZnONPs were used to assess their potential as a micronutrient for the plant and nano adsorbent for the removal of antibiotics (ampicillin) and methylene blue dye from the simulated wastewater. The antibiotic and dye removal were observed under UV light and visible light against contact time. In comparison to control seeds, seeds grown with ZnONPs have shown better germination and seedling. It could be concluded that ZnONPs acted as an important nanosized source of nutrition for agricultural applications. Thus, the effect of ZnONPs has been proven as a nano-based nutrient source for agricultural purposes. The remediation study found that remediation of both ampicillin and methylene blue dye was efficient under UV light under similar experimental parameters from the simulated wastewater by the ZnONPs.

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“…This effect arises because ZnO nanoparticles have a large specific area and surface energy, allowing them to adsorb and accumulate at the membrane and in the cytoplasm. [7,8] OM is a devastating disease caused by a bacterial infection of the medullary spaces, the haversian system, and the proximal bone cortex. It is an inflammation of the bone and its structures caused by pyogenic organisms that spread through the bloodstream, injuries, or surgery.…”

Section: Introductionmentioning

confidence: 99%

“…Finally, ZnO nanoparticles (NPs) may cause bacterial mortality by penetrating the membrane and disrupting its structure. This effect arises because ZnO nanoparticles have a large specific area and surface energy, allowing them to adsorb and accumulate at the membrane and in the cytoplasm [7,8] …”

Section: Introductionmentioning

confidence: 99%

Polycaprolactone Microsphere‐Encapsulated Fluconazole‐Loaded Zinc Oxide and Hydroxyapatite Nanocomposites for Enhanced Biological Performance

Das,

Ringu,

Ghosh

et al. 2024

ChemistrySelect

Self Cite

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Osteomyelitis (OM), a debilitating disease caused by a microbial infection of the bones, continues to pose a formidable obstacle for orthopedic surgeons. The conventional methods for the prevention and treatment of OM are insufficient. In this research work, we developed a strategic green nanostructure using the antifungal drug Fluconazole (FCZ)‐assimilated zinc oxide nanoparticles (ZnO‐NPs) and hydroxyapatite (HAp) nanostructures as filler and hydrophobic polycaprolactone (PCL) as matrix by a solution‐based chemical method. The ceramic carrier‐like nanostructures ZnO and HAp were synthesized by the in situ precipitation method. The physicochemical characterization of the prepared polymer‐coated drug ceramic nanocomposite (FCZ‐ZnO‐HAp‐PCL) was achieved using Fourier transform infrared spectroscopy (FTIR), Field Emission Scanning Electron Microscopy (FESEM), particle size distribution (PSD), X‐ray diffraction (XRD), and Energy‐dispersive X‐ray (EDX) analysis. Furthermore, the biocompatibility and anticancer activity of the nanocomposite were explored by an MTT assay study. Successfully synthesized FCZ‐ZnO‐HAp‐PCL nanocomposite exhibited profound antimicrobial activity against targeted microbe species and potential cytotoxicity towards MCF‐7 human breast adenocarcinoma cell lines, which may be potentially used for the treatment of OM and prospective infections.

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Zinc oxide nanoparticles: an excellent biomaterial for bioengineering applications

Cited by 15 publications

References 108 publications

Therapeutic Potential of Sol–Gel ZnO Nanocrystals: Anticancer, Antioxidant, and Antimicrobial Tri-Action

Therapeutic Potential of Sol–Gel ZnO Nanocrystals: Anticancer, Antioxidant, and Antimicrobial Tri-Action

Scallion Peel Mediated Synthesis of Zinc Oxide Nanoparticles and Their Applications as Nano fertilizer and Photocatalyst for Removal of Organic Pollutants from Wastewater

Polycaprolactone Microsphere‐Encapsulated Fluconazole‐Loaded Zinc Oxide and Hydroxyapatite Nanocomposites for Enhanced Biological Performance

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