Zinc oxide nanoparticle toxicity in embryonic zebrafish: Mitigation with different natural organic matter

Kteeba, Shimaa M.; El-Adawi, Hala; El-Rayis, Osman A.; El-Ghobashy, Ahmed E.; Schuld, Jessica L.; Svoboda, Kurt R.; Guo, Laodong

doi:10.1016/j.envpol.2017.07.042

Cited by 63 publications

(36 citation statements)

References 71 publications

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“…Recently, the impact of HA, alginic acid, BSA, and various forms of dissolved organic matter (DOM) on the toxicity of ZnO NPs to embryonic Danio rerio (D. rerio) was compared. [166] The study showed that HA could most effectively mitigate the toxicity and hatching rate reduction caused by ZnO NPs. [166] In addition, the effects of HA on the developmental toxicity of Ag NPs, SWCNTs, CdSe NPs, and ZnO NPs on D. rerio have been examined.…”

Section: (10 Of 23)mentioning

confidence: 94%

“…[166] The study showed that HA could most effectively mitigate the toxicity and hatching rate reduction caused by ZnO NPs. [166] In addition, the effects of HA on the developmental toxicity of Ag NPs, SWCNTs, CdSe NPs, and ZnO NPs on D. rerio have been examined. [167] Results showed that whilst the overall survival rates were not mitigated by HA, the addition of HA could restore ZnO NP-induced hatching inhibition and reduced head-tail angle in developing D. rerio.…”

Section: (10 Of 23)mentioning

confidence: 94%

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The Crucial Role of Environmental Coronas in Determining the Biological Effects of Engineered Nanomaterials

Wang

et al. 2020

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In aquatic environments, a large number of ecological macromolecules (e.g., natural organic matter (NOM), extracellular polymeric substances (EPS), and proteins) can adsorb onto the surface of engineered nanomaterials (ENMs) to form a unique environmental corona. The presence of environmental corona as an eco–nano interface can significantly alter the bioavailability, biocompatibility, and toxicity of pristine ENMs to aquatic organisms. However, as an emerging field, research on the impact of the environmental corona on the fate and behavior of ENMs in aquatic environments is still in its infancy. To promote a deeper understanding of its importance in driving or moderating ENM toxicity, this study systemically recapitulates the literature of representative types of macromolecules that are adsorbed onto ENMs; these constitute the environmental corona, including NOM, EPS, proteins, and surfactants. Next, the ecotoxicological effects of environmental corona‐coated ENMs on representative aquatic organisms at different trophic levels are discussed in comparison to pristine ENMs, based on the reported studies. According to this analysis, molecular mechanisms triggered by pristine and environmental corona‐coated ENMs are compared, including membrane adhesion, membrane damage, cellular internalization, oxidative stress, immunotoxicity, genotoxicity, and reproductive toxicity. Finally, current knowledge gaps and challenges in this field are discussed from the ecotoxicology perspective.

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Section: (10 Of 23)mentioning

confidence: 94%

Section: (10 Of 23)mentioning

confidence: 94%

The Crucial Role of Environmental Coronas in Determining the Biological Effects of Engineered Nanomaterials

Wang

et al. 2020

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“…Zinc oxide (ZnO) NPs (20 nm) have also been shown to cause delayed development and inhibition of hatching in zebrafish embryos but only at higher concentrations (>0.1 mg/L) [ 77 , 119 ]. Again, surface properties and shape appear to be important.…”

Section: Selected Nanotoxicology Studies In Zebrafishmentioning

confidence: 99%

Zebrafish as a Model to Evaluate Nanoparticle Toxicity

2018

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Nanoparticles are increasingly being developed for in vivo use, from targeted drug delivery to diagnostics, where they have enormous potential, while they are also being used for a variety of applications that can result in environmental exposure for humans. Understanding how specific nanoparticles interact with cells and cell systems is essential to gauge their safety with respect to either clinical or environmental exposure. Zebrafish is being increasingly employed as a model to evaluate nanoparticle biocompatibility. This review describes this model and how it can be used to assess nanoparticle toxicity at multiple levels, including mortality, teratogenicity, immunotoxicity, genotoxicity, as well as alterations in reproduction, behavior and a range of other physiological readouts. This review also provides an overview of studies using this model to assess the toxicity of metal, metal oxide and carbon-based nanoparticles. It is anticipated that this information will inform research aimed at developing biocompatible nanoparticles for a range of uses.

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“…Two compounds were employed as positive controls for general toxicity: diethylaminobenzaldehyde (DEAB, Sigma-Aldrich, Steinheim, Germany), an inhibitor of aldehyde dehydrogenases that causes signi cant pathologies and mortality in zebra sh embryos [25][26][27] and nanoparticles of zinc oxide (ZnO, diameter < 100 nm, catalog #721077-100G, Sigma-Aldrich, Steinheim, Germany) known to cause mortality and morphological deformities in zebra sh embryos and used previously as a positive control in toxicological studies [28][29][30]. In addition, in connection with the assays of neurotoxicity, 1-methyl-4phenyl-1,2,3,6-tetrahydropyridinehydrochloride (MPTP, Sigma-Aldrich, Steinheim, Germany), which causes permanent symptoms of Parkinson's disease in these same embryos, was used as the positive control [31].…”

Section: Chemicalsmentioning

confidence: 99%

AEO-7 Surfactant is “super Toxic” and Induces Severe Cardiac, Liver and Locomotion Damage in Zebrafish Embryos

Al-Asmakh

Majdalawieh

Abdullah

et al. 2020

Preprint

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BackgroundFatty alcohol polyoxyethylene ether-7 (AEO-7), a non-ionic surfactant, has recently been receiving extensive attention from the ocean pipeline industry for its ability to inhibit corrosion. However, the present lack of information concerning the potential environmental toxicity of AEO-7, especially towards aquatic organisms, is a major impediment to its wider application. Here, we assess potential adverse effects of AEO-7 on zebrafish embryos employing a variety of assays, including (i) a mortality/survival assay which allowed the median lethal concentration (LC50) to be calculated; (ii) a teratogenicity assay on the basis of which the no observed effect concentration (NOEC) was determined; and (iii) specific assays of cardiotoxicity, neurotoxicity (based on locomotion), hematopoietic toxicity (the level of hemoglobin as revealed by o-dianisidine staining) and hepatotoxicity (liver steatosis and yolk retention examined by staining with Oil Red O). ResultsAEO-7 caused mortality with a calculated LC50 of 15.35 μg/L, which, according to the U.S. Fish and Wildlife Service (USFWS) Acute Toxicity Rating scale, should be considered “super toxic”. Although at its NOEC (0.8 μg/L), there were no signs of significant teratogenicity, cardiotoxicity, or hemopoiesis toxicity, 3.2 µg/L AEO-7 exerted dramatic detrimental effects on organ development. ConclusionOn the basis of these findings, we recommend that the industrial usage and environmental impact of AEO-7 be re-evaluated and strictly monitored by environmental and public health organizations.

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Zinc oxide nanoparticle toxicity in embryonic zebrafish: Mitigation with different natural organic matter

Cited by 63 publications

References 71 publications

The Crucial Role of Environmental Coronas in Determining the Biological Effects of Engineered Nanomaterials

The Crucial Role of Environmental Coronas in Determining the Biological Effects of Engineered Nanomaterials

Zebrafish as a Model to Evaluate Nanoparticle Toxicity

AEO-7 Surfactant is “super Toxic” and Induces Severe Cardiac, Liver and Locomotion Damage in Zebrafish Embryos

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