Zinc oxide nanoparticle: An effective antibacterial agent against pathogenic bacterial isolates

Ahmad, Irfan; Alshahrani, Mohammad Y.; Wahab, Shadma; Al-Harbi, Alhanouf I.; Nisar, Nazima; Alraey, Yasser; Alqahtani, Abdulaziz; Mir, Mushtaq Ahmad; Irfan, Safia

doi:10.1016/j.jksus.2022.102110

Cited by 25 publications

(14 citation statements)

References 21 publications

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“…The solubility of these phyto compounds depends largely on the solvent which was also seen in the present study since the acetone extract of R. chingii flower showed comparably lesser bactericidal activity against all the three bacteria cultures used in this study. Another important factor contributing during the assessment of the zone of inhibition is the ability of the solvent used for extracting the bioactive phytoconstituents to penetrate and diffuse through the nutrient media used in the study [14][15][16][17]. The results of this study clearly indicated the bactericidal potential of R. chingii flower extracts in various solvents.…”

Section: Discussionmentioning

confidence: 82%

Antibacterial effect of Rubus chingii flower extract against multidrug-resistant bacteria

Amir¹

2022

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Rubus chingii is a well reputed member of Chinese traditional medicine system and is used for managing different ailments since historic times. The present report elucidates the growth impeding effect of R. chingii flower extract against multidrug resistant Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus. The extracts were prepared using standard Soxhlet extraction method using ethanol, methanol and acetone as a solvent. The extracts were further subjected to agar streak method and the stains that showed their sensitivity were further evaluated for minimum inhibitor concentration (MIC) assessment through TCC method. Subsequently the MIC was further used for well diffusion assay. All the strains used in the study showed their sensitivity towards R. chingii flowers extract in respective solvents. Highest antibacterial activity was seen against E. coli and S. aureus whereas the lowest activity was recorded against K. pneumoniae. Thus the study reported herewith provided an insight into the antibacterial efficacy of R. chingii flower extract against MDR E. coli, S. aureus and K. pneumoniae.

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Section: Discussionmentioning

confidence: 82%

Antibacterial effect of Rubus chingii flower extract against multidrug-resistant bacteria

Amir¹

2022

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“…MHB inoculated with MRSA suspension and MHB alone were used as positive and negative controls, respectively. These experiments were repeated three times and the best observation was recorded as the final result [16] , [17] . An MIC 90 /MBC 90 was defined as a MIC/MBC that inhibits/kills 90% of MRSA isolates, while the MIC 50 /MBC 50 was the MIC/MBC value that inhibits/kills 50% of isolates [18] .…”

Section: Methodsmentioning

confidence: 99%

Study of the antibacterial effects of the starch-based zinc oxide nanoparticles on methicillin resistance <i>Staphylococcus aureus</i> isolates from different clinical specimens of patients from Basrah, Iraq

2023

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<abstract> <p>This study aimed to assess the efficacy of starch-based zinc oxide nanoparticles (ZnO-NPs) against methicillin-resistant <italic>Staphylococcus aureus</italic> (MRSA) isolates from clinical specimens in Basrah, Iraq. In this cross-sectional study, 61 MRSA were collected from different clinical specimens of patients in Basrah city, Iraq. MRSA isolates were identified using standard microbiology tests, cefoxitin disc diffusion and oxacillin salt agar. ZnO-NPs were synthesized in three different concentrations (0.1 M, 0.05 M, 0.02 M) by the chemical method using starch as the stabilizer. Starch-based ZnO-NPs were characterized using ultraviolet–visible spectroscopy (UV-Vis), X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), energy dispersive X-ray spectroscopy (EDS), and transmission electron microscopy (TEM). The antibacterial effects of particles were investigated by the disc diffusion method. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the most effective starch-based ZnO-NPs were determined using a broth microdilution assay. The UV-Vis of all concentrations of starch-based ZnO-NPs exhibited a strong absorption band at 360 nm which was characteristic of the ZnO-NPs. XRD assay confirmed the representative hexagonal wurtzite phase of the starch-based ZnO-NPs, and their purity and high crystallinity. The spherical shape with a diameter of 21.56 ± 3.42 and 22.87 ± 3.91 was revealed for the particles by FE-SEM and TEM, respectively. EDS analysis confirmed the presence of zinc (Zn) (61.4 ± 0.54%) and oxygen (O) (36 ± 0.14%). The 0.1 M concentration had the highest antibacterial effects (mean ± SD of inhibition zone = 17.62 ± 2.65 mm) followed by the 0.05 M concentration (16.03 ± 2.24 mm) and the 0.02 M concentration (12.7 ± 2.57 mm). The MIC and the MBC of the 0.1 M concentration were in the range of 25–50 µg/mL and 50–100 µg/mL, respectively. Infections caused by MRSA can be treated with biopolymer-based ZnO-NPs as effective antimicrobials.</p> </abstract>

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“…There is little room for debate about the fact that nanoparticles provide genuine and novel prospects in various sectors, including healthcare and materials research [ 31 ]. These particles are tiny enough to access practically all body parts, including organelles and cells, which may develop novel nanomedicine strategies.…”

Section: Nanomaterials For Indirect and Direct Immunomodulationmentioning

confidence: 99%

Nanomaterials-Based Novel Immune Strategies in Clinical Translation for Cancer Therapy

et al. 2023

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Immunotherapy shows a lot of promise for addressing the problems with traditional cancer treatments. Researchers and clinicians are working to create innovative immunological techniques for cancer detection and treatment that are more selective and have lower toxicity. An emerging field in cancer therapy, immunomodulation offers patients an alternate approach to treating cancer. These therapies use the host’s natural defensive systems to identify and remove malignant cells in a targeted manner. Cancer treatment is now undergoing somewhat of a revolution due to recent developments in nanotechnology. Diverse nanomaterials (NMs) have been employed to overcome the limits of conventional anti-cancer treatments such as cytotoxic, surgery, radiation, and chemotherapy. Aside from that, NMs could interact with live cells and influence immune responses. In contrast, unexpected adverse effects such as necrosis, hypersensitivity, and inflammation might result from the immune system (IS)’s interaction with NMs. Therefore, to ensure the efficacy of immunomodulatory nanomaterials, it is essential to have a comprehensive understanding of the intricate interplay that exists between the IS and NMs. This review intends to present an overview of the current achievements, challenges, and improvements in using immunomodulatory nanomaterials (iNMs) for cancer therapy, with an emphasis on elucidating the mechanisms involved in the interaction between NMs and the immune system of the host.

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Zinc oxide nanoparticle: An effective antibacterial agent against pathogenic bacterial isolates

Cited by 25 publications

References 21 publications

Antibacterial effect of Rubus chingii flower extract against multidrug-resistant bacteria

Antibacterial effect of Rubus chingii flower extract against multidrug-resistant bacteria

Study of the antibacterial effects of the starch-based zinc oxide nanoparticles on methicillin resistance <i>Staphylococcus aureus</i> isolates from different clinical specimens of patients from Basrah, Iraq

Nanomaterials-Based Novel Immune Strategies in Clinical Translation for Cancer Therapy

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