Zinc oxide decorated titania nanostructured layer over Ti metal as a biocompatible and antimicrobial surface for biomedical application

V, Sreya P.; Mathew, Ann; Chukwuike, V.I.; Venkatesan, K.; Raveendran, Subina; Barik, R.C.; Pattanayak, Deepak K.

doi:10.1016/j.surfin.2022.102275

Cited by 8 publications

(8 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The individual photoemission spectra of each element were plotted concerning the C 1s peak position at 284.8 eV. 20 The XPS spectrum of Ti 2p displays two peaks centered at 463.92 and 458.02 eV (Figure 2b) corresponding to the typical binding energies of Ti 2p 1/2 and Ti 2p 3/2 in TiO 2 , respectively. 21 The peaks located around 529.6 and 531.5 eV were assigned to O 1s (Figure 2c) with respect to the previous reports and correspond to lattice oxygen and surface active oxygen, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…The presence of rutile TiO 2 and sodium titanate on TiNa as observed from Raman spectra, was confirmed by the d-spacing values 0.32 nm (110) and 0.72 nm (200), respectively, from the sample results, which is clearly shown in Figure 4a. 20,40 Formation of CeO 2 and Ce 2 O 3 in the Cetreated samples were analyzed with the interplanar spacing values of 0.31 and 0.60 nm, which correspond to the (111) and (011) planes, respectively. 41,42 When samples were treated with Ce, its oxides were formed on the surface with respect to different concentrations.…”

Section: Resultsmentioning

confidence: 99%

“…Surface modification techniques adopted for metals and alloys can be mechanical (grinding, polishing, blasting), chemical (alkali/acid treatment, anodization), or physical (spraying, PVD). ,, These surface modification approaches are mainly aimed at making the implant surface more rough and porous. Enhanced surface roughness as well as the porous nature of the implant will lead to enriched protein adsorption that promotes better cell adhesion and their ingrowth into the porous layers of the surface. , A bioactive surface with a porous nanonetwork structure can be generated onto a Ti/Ti alloy-based implant by a simple alkaline treatment with a high concentration of NaOH. − It is also reported that elements with antimicrobial properties (Ag, Zn, Ce, etc. ), as well as enhancement of osseointegration (Ca, Mg, Zr, Se, Ce etc.…”

Section: Introductionmentioning

confidence: 99%

“…A similar approach for the incorporation of beneficial elements such as Ag, Zn, Ca, and Sr to Ti/Ti alloys was attempted by our research group, and it resulted in an implant with enhanced surface properties with good biocompatibility, which will help fasten the healing process. 8,9,18,20,21 Cerium (Ce) is the most abundant, most reactive rare-earth element of the lanthanide series and exists in two oxidation states (+3 and +4). 23 Cerium oxide or nanoceria can be regarded as a critical rare-earth metal oxide with its unique ability to switch the oxidation states between +3 and +4 depending on the environment.…”

Section: Introductionmentioning

confidence: 99%

“…), can be incorporated into the thus-formed nanonetwork structure by subsequent treatment with a respective elemental solution. ,,, These elements will be decorated over the nanonetwork structure over the surface to promote biocompatibility and add biofunctions to the Ti/Ti alloy-based implants. A similar approach for the incorporation of beneficial elements such as Ag, Zn, Ca, and Sr to Ti/Ti alloys was attempted by our research group, and it resulted in an implant with enhanced surface properties with good biocompatibility, which will help fasten the healing process. ,,,, …”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Cerium Ion-Incorporated Titanium Metal Implants of Enhanced Bioactivity for Biomedical Applications

Mathew

Venkatesan

et al. 2023

ACS Appl. Bio Mater.

Self Cite

View full text Add to dashboard Cite

The enhancement in the performance of metallic bone implants based on commercially pure titanium (CP-Ti) by incorporation of cerium (Ce) ions onto the surface was evaluated. The incorporation of Ce ions onto the CP-Ti surface was carried out by a simple two-step chemical treatment method, where an initial NaOH treatment and then a subsequent treatment with different molar concentrations of ceric nitrate solution followed by heat treatment at 600 °C were carried out. The modified surfaces were observed using field emission scanning electron microscopy (FE-SEM), scanning electron microscopy−energy dispersive X-ray analysis (SEM-EDX), X-ray photoelectron spectroscopy (XPS), the laser Raman spectroscopic technique, high-resolution transmission electron microscopy (HR-TEM), and atomic force microscopy (AFM). The formation of a nanonetwork structure by the initial NaOH treatment and the replacement of Na ions with Ce ions along with different phases of TiO 2 was evident from the surface characterization results. The transition of rutile TiO 2 to anatase TiO 2 in the modified surface is evident from the Raman spectra with respect to the treatment of higher to lower concentrations of ceric nitrate solution. The presence of two different oxidation states of Ce (Ce 3+ and Ce 4+ ) and improvement in the surface wettability were also distinct in the modified samples. Thus, the incorporated Ce ions over the nanostructured titania network showed low cytotoxicity, good cell adhesion, and enhanced extracellular mineralization on MG-63 cells with better protein adsorption in BSA medium. Taken together, the thus-improved nanostructured surface morphology with the anatase TiO 2 phase and distinct extracellular mineralization in the Ce-incorporated Ti metal with good biocompatibility make it a promising candidate for bone implant applications.

show abstract

Section: Resultsmentioning

confidence: 99%