Zinc oxide and copper nanoparticles addition in universal adhesive systems improve interface stability on caries-affected dentin

Gutiérrez, Mário Felipe; Bermudez, J.; Dávila-Sánchez, Andrés; Alegría-Acevedo, L F; Méndez-Bauer, Luján; Hernández, Marcela; Astorga, Jessica; Reis, Alessandra; Loguércio, Alessandro Dourado; Farago, Paulo Vítor; Fernández, Eduardo

doi:10.1016/j.jmbbm.2019.07.024

Cited by 38 publications

(23 citation statements)

References 45 publications

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“…When combined with self-etching adhesives, some calcium complexes were adverted at the resin-dentin interface [ 44 ] ( Figure 4 a,b, Figure 5 a,b,d and Figure 6 a,b,d). ZnO has also provided activity when doped into adhesive resins [ 40 ] without exerting cytotoxic effects on pulp fibroblasts [ 45 ].…”

Section: Resultsmentioning

confidence: 99%

“…Including zinc in the composition of the adhesives, intrafibrillar remineralization at the partially demineralized fibers will become augmented [ 9 ]. Zinc exerts both anti-inflammatory and antibacterial effects [ 40 , 41 , 42 ], as it decreases bacterial biofilm formation and growth [ 41 ]. This highlights the importance of Zn mineralized tissues [ 43 ].…”

Section: Introductionmentioning

confidence: 99%

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Zn-containing Adhesives Facilitate Collagen Protection and Remineralization at the Resin-Dentin Interface: A Narrative Review

et al. 2022

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This is a narrative review of the literature assessing the potential effectiveness of doping dentin polymeric adhesives with zinc compounds in order to improve bonding efficacy, remineralization and protection against degradation. A literature search was conducted using electronic databases, such as PubMed, MEDLINE, DIMDI and Web of Science. Through our search, we found literature demonstrating that Zn-doped dentin adhesives promote protection and remineralization of the resin-dentin interfaces. The increased bioactivity has also facilitated dentinal tubules’ occlusion by crystals’ precipitation contributing to improved sealing efficacy of restorations. Loading dentin adhesives with zinc gives rise to an increase of both crystallinity of mineral and crosslinking of collagen. The main role of zinc, in dentin adhesives, is to inhibit collagen proteolysis. We concluded that zinc exerts a protective effect through binding at the collagen-sensitive cleavage sites of matrix-metalloproteinases (MMPs), contributing to dentin matrix stabilization. Zinc may not only act as a MMPs inhibitor, but also influence signaling pathways and stimulate metabolic effects in dentin mineralization and remineralization processes. Zn-doped adhesives increase the longevity of dentin bonding through MMPs inhibition. Zn poses a remineralization strategy in demineralized dentin.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Zn-containing Adhesives Facilitate Collagen Protection and Remineralization at the Resin-Dentin Interface: A Narrative Review

et al. 2022

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“…The analysis by EDX (Table 3) showed that the C increased from 52.6% to 62% in the GA crosslinked chitosan film while N was not detected. In this regard, Oyrton et al have reported that the presence of glutaraldehyde causes an increase in the percentage of carbon, and hydrogen and a decrease for nitrogen with the increasing degree of glutaraldehyde [42]. In contrast, Li et al observed a decrease in C in the chitosan film with glutaraldehyde [25].…”

Section: Elemental Composition By Edx and Xpsmentioning

confidence: 99%

Zinc Oxide and Copper Chitosan Composite Films with Antimicrobial Activity

et al. 2021

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The role of the oral microbiome and its effect on dental diseases is gaining interest. Therefore, it has been sought to decrease the bacterial load to fight oral cavity diseases. In this study, composite materials based on chitosan, chitosan crosslinked with glutaraldehyde, chitosan with zinc oxide particles, and chitosan with copper nanoparticles were prepared in the form of thin films, to evaluate a new alternative with a more significant impact on the oral cavity bacteria. The chemical structures and physical properties of the films were characterized using by Fourier transform infrared spectroscopy (FTIR,) Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), elemental analysis (EDX), thermogravimetric analysis (TGA), X-ray diffraction (XRD), scanning electron microscopy (SEM), and contact angle measurements. Subsequently, the antimicrobial activity of each material was evaluated by agar diffusion tests. No differences were found in the hydrophilicity of the films with the incorporation of ZnO or copper particles. Antimicrobial activity was found against S. aureus in the chitosan film crosslinked with glutaraldehyde, but not in the other compositions. In contrast antimicrobial activity against S. typhimurium was found in all films. Based on the data of present investigation, chitosan composite films could be an option for the control of microorganisms with potential applications in various fields, such as medical and food industry.

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“…The addition of CuNP/ZnONP in an adhesive system provides more antimicrobial activities, without affecting their bond strength. Moreover, CuNP/ZnONP also inhibited matrix metalloprotease-2, and may improve enamel remineralization [29]. Matrix metalloprotease-2 is associated with the development of dental germ as well as the progression of dental caries in patients with necrotic pulp [30].…”

Section: Nps and Their Role In Dental Caries Controlmentioning

confidence: 99%

Nanostructures as Targeted Therapeutics for Combating Oral Bacterial Diseases

et al. 2021

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Pathogenic oral biofilms are now recognized as a key virulence factor in many microorganisms that cause the heavy burden of oral infectious diseases. Recently, new investigations in the nanotechnology field have propelled the development of novel biomaterials and approaches to control bacterial biofilms, either independently or in combination with other substances such as drugs, bioactive molecules, and photosensitizers used in antimicrobial photodynamic therapy (aPDT) to target different cells. Moreover, nanoparticles (NPs) showed some interesting capacity to reverse microbial dysbiosis, which is a major problem in oral biofilm formation. This review provides a perspective on oral bacterial biofilms targeted with NP-mediated treatment approaches. The first section aims to investigate the effect of NPs targeting oral bacterial biofilms. The second part of this review focuses on the application of NPs in aPDT and drug delivery systems.

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Zinc oxide and copper nanoparticles addition in universal adhesive systems improve interface stability on caries-affected dentin

Cited by 38 publications

References 45 publications

Zn-containing Adhesives Facilitate Collagen Protection and Remineralization at the Resin-Dentin Interface: A Narrative Review

Zn-containing Adhesives Facilitate Collagen Protection and Remineralization at the Resin-Dentin Interface: A Narrative Review

Zinc Oxide and Copper Chitosan Composite Films with Antimicrobial Activity

Nanostructures as Targeted Therapeutics for Combating Oral Bacterial Diseases

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