Zinc nutriture and pregnancy outcome

Tamura, Tsunenobu; Goldenberg, Robert L.

doi:10.1016/0271-5317(95)02068-3

Cited by 100 publications

(71 citation statements)

References 216 publications

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“…In brief, 400 HIV-positive women who were 12-27 weeks of gestation, resided in Dar es Salaam at the time of the first interview, and had the intention to stay in the city until delivery and during the postpartum period were randomly assigned to receive a daily oral dose of 25 mg zinc as zinc sulfate or placebo from enrollment until the end of the study, 6 weeks after delivery. This dose is safe for use during pregnancy (Tamura and Goldenberg, 1996). Both experimental regimens were undistinguishable from each other in taste or appearance.…”

Section: Study Design and Populationmentioning

confidence: 91%

Zinc supplementation to HIV-1-infected pregnant women: Effects on maternal anthropometry, viral load, and early mother-to-child transmission

et al. 2006

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Objective: To examine the effect of zinc supplementation to HIV-1-infected pregnant women on viral load, early mother-tochild transmission of HIV (MTCT), and wasting. Design: Double-blind placebo-controlled randomized clinical trial. Setting: Antenatal clinic in Dar es Salaam, Tanzania. Subjects: Four hundred HIV-1-infected pregnant women. Methods: Women 12-27 weeks of gestation were randomly assigned to receive a daily oral dose of 25 mg zinc or placebo from the day of the first prenatal visit until 6 weeks postdelivery. Weight and mid-upper arm circumference (MUAC) were measured monthly. HIV status of the babies was assessed at birth and at 6 weeks postpartum. Viral load was assessed in a random sample of 100 women at baseline and at the end of the study. Results: Zinc had no effects on maternal viral load or early MTCT. Supplementation was related to a significant threefold increase in the risk of wasting (reaching a MUAC value o22 cm) during an average 22 weeks of observation (RR ¼ 2.7, 95%CI ¼ 1.1, 6.4, P ¼ 0.03), and to a 4 mm decline in MUAC during the second trimester (P ¼ 0.02). Conclusions: Zinc supplementation to HIV-infected pregnant women offers no benefits on viral load or MTCT. The clinical relevance of an apparent decrease in MUAC associated with zinc supplementation is yet to be ascertained. These findings together with the lack of effect on fetal outcomes (reported previously) do not provide support for the addition of zinc supplements to the standard of prenatal care among HIV-infected women.

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Section: Study Design and Populationmentioning

confidence: 91%

Zinc supplementation to HIV-1-infected pregnant women: Effects on maternal anthropometry, viral load, and early mother-to-child transmission

et al. 2006

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“…Whether the dietary zinc intakes of women in rural Southern Ethiopia are sufficient to meet these high requirements during pregnancy has not yet been established. Zinc deficiency has been associated with adverse effects on both maternal health and pregnancy outcome in some studies, specifically pregnancy complications, reduced birth weight and congenital anomalies [8][9][10] .…”

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confidence: 99%

Inadequate intakes of dietary zinc among pregnant women from subsistence households in Sidama, Southern Ethiopia

Abebe

Bogale

Hambidge

et al. 2008

Public Health Nutr.

104

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Objective: To assess the prevalence of zinc inadequacy based on dietary intakes and plasma zinc concentrations and, simultaneously, the prevalence of inadequate intakes of energy, protein, calcium and iron. Design: A cross-sectional study of a convenience sample of subsistence farming households in Sidama, Southern Ethiopia. Subjects: Dietary intakes were calculated from 1-day weighed food records and 40 repeats from 99 pregnant women in the third trimester using analysed values of major staple foods for zinc, iron, calcium and phytate. The distribution of observed intakes was adjusted for usual intakes and the prevalence of inadequacy estimated using the estimated average requirement (EAR) cutpoint method. Prevalence of inadequacy for zinc, protein and iron intakes were compared with those based on biochemical measures. Results: Prevalence of zinc inadequacy was very high: 99% for US FNB EAR and 100% for IZiNCG EAR compared to 72% based on low plasma zinc concentrations. Corresponding prevalence estimates for iron were much lower: 4% for inadequate intakes based on US FNB EAR vs. 8.7% for iron deficiency anaemia (haemoglobin , 110 g l 21 ; ferritin , 12 mg l 21 ) and 32.3% for low storage iron. Prevalence of inadequacy for protein was 100% for adjusted intakes and 91% for serum albumin , 32 g l 21 . For calcium, 74% were at risk for inadequate intakes. Conclusion: The high prevalence of inadequate intakes of zinc and protein was reasonably consistent with those based on biochemical measures. Such dietary deficits could be overcome by regular consumption of cellular animal protein. In contrast, both dietary and biochemical measures of iron inadequacy were low.

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“…Zinc is one of the essential nutrients for increasing immunity against diseases (Rosa et al, 2010). It is an essential nutrient for all forms and stages of life and its deficiency in humans has been linked to a number of health problems (Prasad, 1984;Tamura & Goldenberg, 1996;Welch & Graham, 1999;Brown, Wuehler, & Peerson, 2001;Welch & Graham, 2004). Biofortification of grains and foods (Olsen & Palmgren, 2014;VazPatto et al, 2015) via agronomic means is becoming wide-spread (especially in case of Zn) (Olsen & Palmgren, 2014;Tan et al, 2015) | AYENI Et Al.…”

Section: Introductionmentioning

confidence: 99%

Iron and zinc levels in Vigna unguiculata (L.) Walp under varying phosphorus and fixed nitrogen treatment conditions

Ayeni

Ikwebe

Onyezili

2018

Food and Energy Security

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Using phosphate fertilizer (particularly at high levels) to improve the phosphorus (P) level of soils during the cultivation of legumes and other cereals unfortunately has negative effect on the levels of micronutrients like zinc (Zn) in grains. This study and cowpea is also at the heart of the fight against micronutrient deficiency due to its ability to accumulate Fe and Zn in both grains and leaves (Mamiro, Mbwaga, Mamiro, Mwanri, & Kinabo, 2011).However, micronutrient-deficient soils are widespread; many millions of hectares of arable land worldwide are deficient in one or more micronutrient elements (Rengel, 2015). Further compounding this is the low phosphorus (P) utilization efficiency of the cowpea (Emechebe, Singh, Leleji, Atokple, & Adu, 1991). In addition, legumes store P as phytate (PA) which, together with inositol penta phosphate, is one of the main inhibitors of Zn absorption (Kaya, Küçükyumuk, & Erdal, 2009). For diffusion-supplied micronutrients, the uptake rate is governed by the soil nutrient supply, and fertilization with micronutrients (more so in case of Zn than Fe) can be effective in increasing the concentration of micronutrients at the soil-root interface (Rengel, 2015). There are growing concerns, however, that the emphasis on increasing cereal yields by the application of macronutrients alone may lead to deficiencies of micronutrients, mainly Fe and Zn, and also vitamins, in diets of the poor who rely on a cereal-based food supply (Graham & Welch, 1996). It is common practice to use P fertilizer to improve the P level of the soil during the cultivation of legumes. Unfortunately, high level of phosphate fertilization of soil has been reported to have negative effect on the levels of Zn in sorghum (Buerkert, Haake, & Ruckwied, 1998) and other cereals. Earlier reports (Zhu, Smith, & Smith, 2001;Gianquinto, Abu-Rayyan, Tola, Piccotino, & Pezzarossa, 2000;Mandal & Mandal, 1990;Haldar & Mandal, 1981;Orabi, Mashadi, Abdallah, & Morsy, 1981;Takkar, Mann, Bansal, Randhawa, & Singh, 1975), and more recently Ova, Kutman, Ozturk, and Cakmak (2015) and Drissi, AïtHoussa, Bamouh, Coquant, and Benbella (2015) have all drawn negative correlations between P fertilization and Zn levels in various cereal (wheat and maize) and leguminous plants. Benvindo, Prado, Nóbrega, and Flores (2014) even reported a corresponding decrease in foliar Zn levels with increase in P levels.There is also the well-documented issue of arbuscular mycorrhizal fungi (AMF) that greatly enhance P uptake in low P soil. Although, P application reportedly and significantly increases grain and fodder yields, it decreases AMF colonization of cowpea roots (Saidou, Singh, Abaidoo, Iwuafor, & Sanginga, 2012). This inverse relationship between P fertilization and levels of micronutrients in crops is a source of concern, and as noted by Graham and Welch (1996), may lead to deficiencies of micronutrients, mainly Fe and Zn, and also vitamins, in diets of the poor who rely on a cereal-based food supply of these micronutrients. Also, as ...

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Zinc nutriture and pregnancy outcome

Cited by 100 publications

References 216 publications

Zinc supplementation to HIV-1-infected pregnant women: Effects on maternal anthropometry, viral load, and early mother-to-child transmission

Zinc supplementation to HIV-1-infected pregnant women: Effects on maternal anthropometry, viral load, and early mother-to-child transmission

Inadequate intakes of dietary zinc among pregnant women from subsistence households in Sidama, Southern Ethiopia

Iron and zinc levels in Vigna unguiculata (L.) Walp under varying phosphorus and fixed nitrogen treatment conditions

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