Zinc nutrition in healthy subjects and patients with taste impairment from the view point of zinc ingestion, serum zinc concentration and angiotensin converting enzyme activity

Dietary zinc intake and its effects on zinc nutrition in healthy Japanese living in the central area of Japan

“…These findings were in line with our previous conclusion that the ACE ratio is a more sensitive indicator than the concentration of zinc in the serum in evaluating dietary zinc nutrition (18)(19)(20).…”

“…Recently, we developed a new test for the assessment of zinc deficiency taking the ratio of apo/holoactivities of angiotensin converting enzyme (ACE), a zinc dependent enzyme, as an index, suggesting that the ratio of apo/holo-ACE activities (ACE ratio) is a more sensitive index of zinc nutrition than measuring zinc concentration in the serum (18)(19)(20). In the present study, we first examined the daily zinc intake from each food group in healthy Japanese living in the central area of Japan (Nagano prefecture) by means of the 72-h recall method.…”

Albumin-normalized serum zinc: a clinically useful parameter for detecting taste impairment in patients undergoing dialysis

“…Recent literature has shown that zinc supplementation can effectively improve idiopathic and zinc-deficient hypogeusia [21][22][23][24]27,30,31]. In this study, we hypothesized that serum zinc was associated with taste impairment, when normalized with serum albumin levels.…”

Protein calorie malnutrition, nutritional intervention and personalized cancer care

“…Often, people who feel they have a problem with their sense of taste are experiencing a loss of smell instead of a loss of taste [139]. Zinc plays an important role in taste perception, and zinc deficiency is often responsible for taste perception abnormalities in otherwise healthy persons [140], in various diseases [86, 141], and in drug-induced taste disorders [142]. Beneficial effects of zinc sulfate [80, 143, 144] or polaprezinc (zinc-L-carnosine) [145] on taste disturbances have been reported in patients with head and neck cancer or lung cancer (Figure 2).…”