Zinc-mineralized diatom biosilica/hydroxybutyl chitosan composite hydrogel for diabetic chronic wound healing

Ding, Yuqi; Mu, Yuzhi; Hu, Yi; Liu, Jiahao; Su, Chang; Sun, Xiaojie; Chen, Xiguang; Jia, Nan; Feng, Chao

doi:10.1016/j.jcis.2023.11.083

Cited by 6 publications

(5 citation statements)

References 26 publications

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“…Based on the findings of the later study, human-derived embryonic stem cell or induced pluripotent stem cell-derived acellular embryoid bodies can be used to promote diabetic wound healing in combination with hydroxybutyl chitosan hydrogels for clinical translation in the future ( Zhang et al ., 2024 ). Ding et al ., (2024) have also reported that inorganic zinc mineralized diatom biosilica and hydroxybutyl chitosan composite hydrogel have the potential to be used as a therapeutic dressing for diabetic chronic wounds. Louiselle et al ., (2021) concluded that treatment of diabetic wounds will likely require a multi-modal approach including management of underlying diabetes and control of hyperglycemia, topical therapeutics, and prevention of secondary infection and inflammation.…”

Section: Discussionmentioning

confidence: 99%

Effect of pomegranate peel with/without autologous bone marrow on healing of acute cutaneous wounds in alloxan-induced diabetic rabbits

Sobayil,

Alsupail,

Tharwat

2024

Open Vet J

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Background: Healing of bum wounds is a commonly associated with many complications. Every year various new repair materials are developed and experimentally used for treating burn wounds. Humans with diabetes mellitus usually suffer from chronic wound healing. Vascular, neuropathic, immune function, and biochemical abnormalities each contribute to the altered tissue repair. One underlying factor that accompanies all diabetic ulcerations is poor vascular flow, a circumstance that impedes proper wound healing. Numerous studies have highlighted the importance of adequate vascular sufficiency and vessel proliferation in tissue repair and the lack thereof in diabetic wound healing. Other studies have looked at whether disarrayed capillary remodeling and maturation of vessels might play a role in impaired diabetic wound healing. Aim: This investigation has been planned to report the influence of treatment with a mixture of both the powder of pomegranate peel accompanied with an autologous bone marrow on cure of burn injuries in experimentally induced diabetic rabbits. Methods: Alloxan monohydrate has been applied to create diabetes in 50 rabbits. Then in each rabbit, two deep second-degree burn wounds were experimentally created. The animals were then divided randomly into 5 treatment sections: non-treatment controls (C1), treated with an available commercial powder for wound (C2), treatment with powder of pomegranate peel (PP), treatment with bone marrow alone (BM), and final group treated with PP powder with bone marrow (PPBM). The speed of wound closure and the histopathological changes during healing were measured. The levels of the biomarkers of rabbit platelet derived growth factor AA (PDGF-AA) and rabbit protease activated receptor 1 (PAR-1) were measured on days 0, 4, 8 and 12. Results: Wounds healing was markedly more rapid in all the treatment groups versus the control non-treated group. Interestingly, a rapid wound cure was significantly observed in PPBM group versus the other treatment ones. The histological assessment clarified a significant elevation in the fibroblast and collagen scores in PPBM group versus the other sections. In addition, there were significant increases in the serum levels of the biomarkers PDGF-AA and PAR-1 among groups. Conclusion: Dependent on the results of current research, it can be concluded that both PP powder with BM (PPBM) significantly accelerate healing process of burn wounds in experimentally induced diabetic rabbits.

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Section: Discussionmentioning

confidence: 99%

Effect of pomegranate peel with/without autologous bone marrow on healing of acute cutaneous wounds in alloxan-induced diabetic rabbits

Sobayil,

Alsupail,

Tharwat

2024

Open Vet J

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“… 42 , 98 , 99 Certainly, additional hydrogels have been engineered to exert anti-inflammatory effect, thereby directly enhancing the process of diabetic wound healing. For instance, Ding et al 100 developed a temperature-sensitive composite hydrogel (ZnDBs/HBC) combining inorganic zinc mineralized diatom biosilica (ZnDBs) with hydroxybutyl chitosan (HBC). This composite hydrogel demonstrated the ability to diminish the inflammatory response, expedite the shift from the inflammatory phase, and promote the formation of the epidermal layer through the release of zinc.…”

Section: The Complex Microenvironment Of Diabetic Wounds and The Cust...mentioning

confidence: 99%

Microenvironmental dynamics of diabetic wounds and insights for hydrogel-based therapeutics

Zhao,

et al. 2024

J Tissue Eng

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The rising prevalence of diabetes has underscored concerns surrounding diabetic wounds and their potential to induce disability. The intricate healing mechanisms of diabetic wounds are multifaceted, influenced by ambient microenvironment, including prolonged hyperglycemia, severe infection, inflammation, elevated levels of reactive oxygen species (ROS), ischemia, impaired vascularization, and altered wound physicochemical properties. In recent years, hydrogels have emerged as promising candidates for diabetic wound treatment owing to their exceptional biocompatibility and resemblance to the extracellular matrix (ECM) through a three-dimensional (3D) porous network. This review will first summarize the microenvironment alterations occurring in the diabetic wounds, aiming to provide a comprehensive understanding of its pathogenesis, then a comprehensive classification of recently developed hydrogels will be presented, encompassing properties such as hypoglycemic effects, anti-inflammatory capabilities, antibacterial attributes, ROS scavenging abilities, promotion of angiogenesis, pH responsiveness, and more. The primary objective is to offer a valuable reference for repairing diabetic wounds based on their unique microenvironment. Moreover, this paper outlines potential avenues for future advancements in hydrogel dressings to facilitate and expedite the healing process of diabetic wounds.

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“…Polymer hydrogels with three-dimensional (3D) network structures and water as the dispersion medium are formed by cross-linking hydrophilic polymers. Polymer hydrogels have become the preferred materials for use in human health monitoring, tissue engineering, environmental protection, and agricultural applications, as well as in the electronic-gel, and food industries due to their flexible synthesis methods, adjustable component compositions and mechanical properties, unique biocompatibilities, and highly moist environment for cellular tissue growth. − Polymer hydrogels have been widely used in the aforementioned traditional fields. However, their applications in high-tech fields related to luminophores are limited.…”

Section: Introductionmentioning

confidence: 99%

Silicone-Enhanced Polyvinyl Alcohol Hydrogels with Intrinsic Photoluminescence and High Mechanical Intensity

Zhang,

Guan,

Chen

et al. 2024

ACS Sustainable Chem. Eng.

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Photoluminescent hydrogels show great potential in the fields of information storage and security, environmental monitoring and protection, in vivo noninvasive monitoring, drug delivery, and tissue engineering. Current fluorescent hydrogels are prepared by coupling or doping fluorescent units, such as semiconductor quantum dots, metal−ligand complexes, lanthanide ions, and organic dyes, into polymer hydrogel matrices. However, conventional fluorescent hydrogels have intrinsic defects, including poor photostability, toxicity, and low mechanical strength, which severely limit their applications. In this study, we developed an intrinsically photoluminescent dual-network hydrogel with excellent mechanical properties. Poly(vinyl alcohol) formed the first hydrogel network, with aminopolysiloxane and citric acid forming the second (APSi network) via amidation-cross-linking chemistry. The introduction of the APSi network endowed the hydrogel with photoluminescence and enhanced mechanical properties, which can be adjusted by changing the APSi-network content. The innovatively developed hydrogel possesses intrinsic photoluminescence, excellent light stability, tunable mechanical properties, and is highly biocompatible, which highlights its potential applicability in many fields. This study provides a simple and versatile strategy for preparing novel fluorescent hydrogels with multidisciplinary application potential.

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Zinc-mineralized diatom biosilica/hydroxybutyl chitosan composite hydrogel for diabetic chronic wound healing

Cited by 6 publications

References 26 publications

Effect of pomegranate peel with/without autologous bone marrow on healing of acute cutaneous wounds in alloxan-induced diabetic rabbits

Effect of pomegranate peel with/without autologous bone marrow on healing of acute cutaneous wounds in alloxan-induced diabetic rabbits

Microenvironmental dynamics of diabetic wounds and insights for hydrogel-based therapeutics

Silicone-Enhanced Polyvinyl Alcohol Hydrogels with Intrinsic Photoluminescence and High Mechanical Intensity

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