Zinc levels and infections in hospitalized patients with AIDS

Koch, Johannes; Neal, Elizabeth A; Schlott, Martin J; Garcia-Shelton, Yvette L; Chan, Mary F.; Weaver, Kristin; Cello, John P.

doi:10.1016/s0899-9007(96)00173-6

Cited by 58 publications

(39 citation statements)

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“…A number of observational studies have documented low dietary intake of zinc in large percentages of HIV-infected adults (Baum et al, 1994(Baum et al, , 2003Tang et al, 1996). By using zinc plasma concentrations, the prevalence of zinc deficiency among HIV-infected adults has been reported to be as high as 25-50% in some settings (Bogden et al, 1990;Beach et al, 1992;Baum et al, 1995Baum et al, , 1997bKoch et al, 1996), and to correlate positively with the stage of disease (Baum et al, 1997b;Bogden et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Zinc supplementation to HIV-1-infected pregnant women: Effects on maternal anthropometry, viral load, and early mother-to-child transmission

et al. 2006

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Objective: To examine the effect of zinc supplementation to HIV-1-infected pregnant women on viral load, early mother-tochild transmission of HIV (MTCT), and wasting. Design: Double-blind placebo-controlled randomized clinical trial. Setting: Antenatal clinic in Dar es Salaam, Tanzania. Subjects: Four hundred HIV-1-infected pregnant women. Methods: Women 12-27 weeks of gestation were randomly assigned to receive a daily oral dose of 25 mg zinc or placebo from the day of the first prenatal visit until 6 weeks postdelivery. Weight and mid-upper arm circumference (MUAC) were measured monthly. HIV status of the babies was assessed at birth and at 6 weeks postpartum. Viral load was assessed in a random sample of 100 women at baseline and at the end of the study. Results: Zinc had no effects on maternal viral load or early MTCT. Supplementation was related to a significant threefold increase in the risk of wasting (reaching a MUAC value o22 cm) during an average 22 weeks of observation (RR ¼ 2.7, 95%CI ¼ 1.1, 6.4, P ¼ 0.03), and to a 4 mm decline in MUAC during the second trimester (P ¼ 0.02). Conclusions: Zinc supplementation to HIV-infected pregnant women offers no benefits on viral load or MTCT. The clinical relevance of an apparent decrease in MUAC associated with zinc supplementation is yet to be ascertained. These findings together with the lack of effect on fetal outcomes (reported previously) do not provide support for the addition of zinc supplements to the standard of prenatal care among HIV-infected women.

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Section: Introductionmentioning

confidence: 99%

Zinc supplementation to HIV-1-infected pregnant women: Effects on maternal anthropometry, viral load, and early mother-to-child transmission

et al. 2006

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“…59 Low serum zinc levels were reported by several authors in HIV infected adults. [61][62][63] Low plasma selenium levels were also reported in HIV-infected adults. 64,65 It should be noted that micronutrient concentrations in the blood are affected by how much of the micronutrients that are present in the body and by infection which increases the levels of some (such as ferritin) and decreases the levels of others (such as vitamins and zinc).…”

Section: Impact Of Trace Elements Deficiencies In Hiv Infectionmentioning

confidence: 99%

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2018

TJNPR

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“…The incident of zinc deficiency in HIV infection has been documented in multiple studies (Flavier et al, 1992). In a survey of 228 in patients with AIDS, 29 percent had low serum zinc and 21% had marginally low serum zinc levels (Koch et al, 1996). The presence of zinc deficiency in these patients significantly increased the chance of bacterial infection (Koch et al, 1996).…”

Section: Imentioning

confidence: 99%

“…In a survey of 228 in patients with AIDS, 29 percent had low serum zinc and 21% had marginally low serum zinc levels (Koch et al, 1996). The presence of zinc deficiency in these patients significantly increased the chance of bacterial infection (Koch et al, 1996). Deficiency of zinc in AIDS patients occur as a result of malabsorption, medication, altered metabolic states, fluid loss from nausea, vomiting and diarrhea (Gelb et al, 1986).…”

Section: Imentioning

confidence: 99%