Zinc ions have a potential to attenuate both Ni ion uptake and Ni ion-induced inflammation

Onodera, Ryo; Asakawa, Shuichi; Segawa, Ryosuke; Mizuno, Natsumi; Ogasawara, Kunio; Hiratsuka, Masahiro; Hirasawa, Noriyasu

doi:10.1038/s41598-018-21014-8

Cited by 11 publications

(3 citation statements)

References 32 publications

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“…Zinc is an essential trace element with antioxidant [ 14 – 16 ] and anti-inflammatory [ 17 , 18 ] properties. It plays a critical role in neuronal signaling and is also known as a cofactor for antioxidant enzymes [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Zinc supplementation affects favorably the frequency of migraine attacks: a double-blind randomized placebo-controlled clinical trial

Ahmadi

Mazloumi-Kiapey

Sadeghi

et al. 2020

Nutr J

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Background Observational studies have shown a link between zinc deficiency and migraine headaches. We aimed to examine the effect of zinc supplementation on the characteristics of migraine attacks in patients with migraine. Methods This randomized clinical trial was conducted on 80 patients with migraine. Patients were randomly assigned to receive either zinc sulfate (220 mg/d zinc sulfate) or placebo (lactose) for 8 weeks. Anthropometric measures, serum zinc concentrations, and characteristics of migraine attacks (headache severity, frequency and duration of migraine attacks, and headache daily results) were assessed at baseline and end of the trial. Results Compared with the placebo, zinc supplementation resulted in a significant reduction in headache severity (− 1.75 ± 1.79 vs. -0.80 ± 1.57; P = 0.01) and migraine attacks frequency (− 2.55 ± 4.32 vs. -0.42 ± 4.24; P = 0.02) in migraine patients. However, the observed reduction for headache severity became statistically non-significant when the analysis was adjusted for potential confounders and baseline values of headache severity. Other characteristics of migraine attacks including the duration of attacks and headache daily results were not altered following zinc supplementation either before or after controlling for covariates. Conclusion Zinc supplementation had a beneficial effect on the frequency of migraine attacks in migraine patients. Additional well-designed clinical trials with a long period of intervention and different dosages of zinc are required. Trial registration code IRCT20121216011763N23 at www.irct.ir.

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Section: Introductionmentioning

confidence: 99%

Zinc supplementation affects favorably the frequency of migraine attacks: a double-blind randomized placebo-controlled clinical trial

Ahmadi

Mazloumi-Kiapey

Sadeghi

et al. 2020

Nutr J

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“…physical contact with epithelial cells rather than particle absorption into the cells. Nickel ions are easily taken into cells (Edwards et al, 1998), where Zn transporters, perhaps members of the Zrt-and Irt-like protein family, are thought to regulate Ni influx (Onodera et al, 2018). NiCl 2 is easily absorbed into the epithelium and therefore has less influence on the surface of epithelia.…”

Section: Discussionmentioning

confidence: 99%

A comparative study of nickel nanoparticle and ionic nickel toxicities in zebrafish: histopathological changes and oxidative stress

2019

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Industry demand for nanomaterials is growing, but metal nanoparticle toxicity is not fully understood. For example, nickel nanoparticles (NiNPs) are used in electric capacitors, and their consumption is increasing, but there have been few reports of their toxicity and environmental effects. To elucidate the toxicological characteristics of NiNPs, we investigated their effects on the histopathology and oxidative states of zebrafish (Danio rerio) and compared the results with those of ionic nickel. Zebrafish exposed to four different concentrations of NiNPs or NiCl 2 for 72 hr or 7 days were subjected to histopathological analysis, and tissue samples were subjected to analyses for oxidative stress and gene expression. High concentrations of both NiNPs and NiCl 2 caused tissue damage in the gills, digestive tract, and liver. The damage was typically characterized by epithelial degeneration and necrosis in the gills, esophagus, and intestines, as well as by lipid loss and palisade pattern degradation in the liver. The damages to the gills, esophagus, and intestines were more severe after exposure to NiNPs, but exposure to NiCl 2 led to more severe liver damage. Exposure to NiNPs increased lipid peroxidation in the skin but decreased it in the liver and intestines; exposure to NiCl 2 increased lipid peroxidation in the intestines. Only exposure to NiCl 2 changed antioxidative responses, enzymatic antioxidant activities, and metallothionein gene expression. These results indicate that NiNPs, which are highly adsorptive, cause severe damage to the epithelium by physical contact with the cell surface and production of reactive oxygen spices, whereas ionic nickel, which is absorptive, affects cellular antioxidative responses by absorption into the body and delivery to the liver.

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“…Zinc is an anti‐inflammatory 5,6 and antioxidant 7–9 trace element. As a cofactor for antioxidant enzymes, it plays a crucial role in neuronal signaling 10 .…”

Section: Introductionmentioning

confidence: 99%

Dietary zinc intake and migraine in adults: a cross‐sectional analysis of the National Health and Nutrition Examination Survey 1999–2004

et al. 2023

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Objective The study examined the relationship between dietary zinc intake and migraine. Background Neuroinflammatory and oxidative stress are involved in the pathogenesis of migraine. Little is known about the effects of zinc, an anti‐inflammatory and antioxidant trace element, on migraine. Methods The US National Health and Nutrition Examination Survey data from 1999 to 2004 were analyzed for this cross‐sectional study. Participants who had severe headache or migraine were classified as having migraine. Dietary zinc intake was evaluated using the 24 h dietary recall system. Results A total of 11,088 participants were included, of whom, 20.2% (2236/11,088) reported having migraine disease. Compared to the lowest dietary zinc intake quintile (Q1, ≤5.9 mg/day), the adjusted odds ratios for migraine in Q2 (6.0–8.4 mg/day), Q3 (8.5–11.2 mg/day), Q4 (11.3–15.7 mg/day), and Q5 (≥15.8 mg/day) were 0.73 (95% confidence interval [CI]: 0.61–0.88, p = 0.004), 0.71 (95% CI: 0.56–0.91, p = 0.013), 0.71 (95% CI: 0.57–0.90, p = 0.008), and 0.70 (95% CI: 0.52–0.94, p = 0.029), respectively. Sensitivity analysis of zinc supplementation survey participants also showed an association between dietary zinc intake and migraine. Compared to the lowest total zinc intake quintile (Q1: 0.5–9.6 mg/day), the adjusted odds ratios for migraine in Q3 (19.3–24.3 mg/day) and Q4 (24.4–32.5 mg/day) were 0.62 (95% CI: 0.46–0.83, p = 0.019) and 0.67 (95% CI: 0.49–0.91, p = 0.045), respectively. Conclusions Our findings indicate an inverse association between dietary zinc intake and migraine in adult Americans.

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Zinc ions have a potential to attenuate both Ni ion uptake and Ni ion-induced inflammation

Cited by 11 publications

References 32 publications

Zinc supplementation affects favorably the frequency of migraine attacks: a double-blind randomized placebo-controlled clinical trial

Zinc supplementation affects favorably the frequency of migraine attacks: a double-blind randomized placebo-controlled clinical trial

A comparative study of nickel nanoparticle and ionic nickel toxicities in zebrafish: histopathological changes and oxidative stress

Dietary zinc intake and migraine in adults: a cross‐sectional analysis of the National Health and Nutrition Examination Survey 1999–2004

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