Zinc ions efflux from lymphocytes in vitro in the presence of a calcium and magnesium ionic environment and its changes following administration of verapamil

Tubek, Sławomir

doi:10.1007/bf02698080

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…The results suggested that both extracellular and intracellular zinc increases under pathological conditions in cardiomyocytes and can alter the L‐type Ca 2+ channel currents ( I Ca), but their effects are not in the same order and same manner (Turan ). Verapamil has an enhancing effect on zinc efflux from isolated lymphocytes, suggesting that calcium channel blockers might result in better zinc homeostatic regulation in diseases of the cardiovascular system (Tubek ). A correlation between use of thiazides and incidence of zincuria has been reported.…”

Section: Zinc and The Cardiovascular Systemmentioning

confidence: 99%

Zinc: The Metal of Life

Kaur

Gupta

Saraf

et al. 2014

Comp Rev Food Sci Food Safe

161

103

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The importance of zinc was 1st reported for Aspergillus niger. It took over 75 y to realize that zinc is also an essential trace element for rats, and an additional 30 y went by before it was recognized that this was also true for humans. The adult body contains about 2 to 3 g of zinc. Zinc is found in organs, tissues, bones, fluids, and cells. It is essential for many physiological functions and plays a significant role in a number of enzyme actions in the living systems. Bioinformatics estimates report that 10% of the human proteome contains zinc-binding sites. Based on its role in such a plethora of cellular components, zinc has diverse biological functions from enzymatic catalysis to playing a crucial role in cellular neuronal systems. Thus, based on the various published studies and reports, it is pertinent to state that zinc is one of the most important essential trace metals in human nutrition and lifestyle. Its deficiency may severely affect the homeostasis of a biological system. This review compiles the role of zinc in prophylaxis/therapeutics and provides current information about its effect on living beings.

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Section: Zinc and The Cardiovascular Systemmentioning

confidence: 99%

Zinc: The Metal of Life

Kaur

Gupta

Saraf

et al. 2014

Comp Rev Food Sci Food Safe

161

103

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“…Changes in zinc metabolism after the administration of medications that improve hemodynamic function and lower the pre-and afterload of the left ventricle, such as spironolactone, digoxine, angiotensin-converting enzyme inhibitors, or calcium channel blockers, suggest a role of zinc in processes of blood pressure changes and heart muscle hypertrophy [36][37][38][39][40][41][42][43][44]. The influence of zinc on blood pressure is multifactorial.…”

Section: Discussionmentioning

confidence: 99%

Selected Zinc Metabolism Parameters and Left Ventricle Mass in Echocardiographic Examination in Primary Arterial Hypertension

Tubek

2007

Biol Trace Elem Res

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The basal systolic and diastolic blood pressure, body mass index, left ventricular mass, serum and lymphocyte zinc levels, serum aldosterone, plasma rennin and angiotensin-converting enzyme activities, sodium and potassium levels, and the total and ouabain-dependent rate constants of zinc efflux from lymphocytes were measured in a group of 41 individuals of both sexes (overall age 46.3 +/- 11.4 years), of which 18 were women (48.5 +/- 7.1 years old) and 23 were men (44.7 +/- 13.8 years old). There were no significant differences between these parameters while dividing the subjects into groups according to sex, despite differences in weight, left ventricle mass, plasma rennin activity, and serum aldosterone content. Only the total and ouabain-dependent rate constants of zinc efflux from lymphocytes slightly negatively correlated to left ventricular mass, r = -0.30 to r = -0.36. This may constitute indirect evidence of zinc deficiency in cardiomyocytes of some hypertensive individuals with left ventricular hypertrophy.

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