Zinc inhibits lethal inflammatory shock by preventing microbe‐induced interferon signature in intestinal epithelium

Souffriau, Jolien; Timmermans, Steven; Vanderhaeghen, Tineke; Wallaeys, Charlotte; Looveren, Kelly Van; Aelbrecht, Lindsy; Dewaele, Sylviane; Vandewalle, Jolien; Goossens, Evy; Verbanck, Serge; Boyen, Filip; Eggermont, Melanie; Commer, Lindsey De; Rycke, Riet De; Bruyne, Michiel De; Tito, Raúl Y.; Ballegeer, Marlies; Vandevyver, Sofie; Velho, Tiago; Moita, Luís F.; Hochepied, Tino; Bosscher, Karolien De; Raes, Jeroen; Immerseel, Filip Van; Beyaert, Rudi; Libert, Claude

doi:10.15252/emmm.201911917

Cited by 13 publications

(6 citation statements)

References 61 publications

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“…Souffriau et al identified that Zn antagonized TNFinduced necroptosis in Paneth cells via modulating intestinal microbiota. Modified composition of the gut microbiota strongly downregulated interferon-stimulated response (ISRE) genes and IRF genes, ameliorating TNF-induced necroptosis (192). Zn also inhibited neuronal ferroptosis in spinal cord injured mouse model.…”

Section: Zn and Zn Binding Protein Inhibit Regulated Necrosismentioning

confidence: 99%

Crosstalk between regulated necrosis and micronutrition, bridged by reactive oxygen species

Zhang

Liu²,

Dai³

et al. 2022

Front. Nutr.

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The discovery of regulated necrosis revitalizes the understanding of necrosis from a passive and accidental cell death to a highly coordinated and genetically regulated cell death routine. Since the emergence of RIPK1 (receptor-interacting protein kinase 1)-RIPK3-MLKL (mixed lineage kinase domain-like) axis-mediated necroptosis, various other forms of regulated necrosis, including ferroptosis and pyroptosis, have been described, which enrich the understanding of pathophysiological nature of diseases and provide novel therapeutics. Micronutrients, vitamins, and minerals, position centrally in metabolism, which are required to maintain cellular homeostasis and functions. A steady supply of micronutrients benefits health, whereas either deficiency or excessive amounts of micronutrients are considered harmful and clinically associated with certain diseases, such as cardiovascular disease and neurodegenerative disease. Recent advance reveals that micronutrients are actively involved in the signaling pathways of regulated necrosis. For example, iron-mediated oxidative stress leads to lipid peroxidation, which triggers ferroptotic cell death in cancer cells. In this review, we illustrate the crosstalk between micronutrients and regulated necrosis, and unravel the important roles of micronutrients in the process of regulated necrosis. Meanwhile, we analyze the perspective mechanism of each micronutrient in regulated necrosis, with a particular focus on reactive oxygen species (ROS).

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Section: Zn and Zn Binding Protein Inhibit Regulated Necrosismentioning

confidence: 99%

Crosstalk between regulated necrosis and micronutrition, bridged by reactive oxygen species

Zhang

Liu²,

Dai³

et al. 2022

Front. Nutr.

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“…Zn 2+ is an essential but toxic microelement in high concentrations and can serve as an antimicrobial strategy for Mycobacterium [ 43 , 44 ], which can provoke chronic inflammation related to cancer pathogenesis [ 45 ]. Meanwhile, the P1B-type ATPase CtpG (Rv3270) was recently identified as a Zn 2+ efflux transporter via the CmtR-CtpG-Zn 2+ regulatory pathway that enhances mycobacterial resistance to Zn 2+ toxicity because the accumulation of Zn 2+ can contribute to ROS detoxification in mycobacterial cells [ 46 ].…”

Section: Metal Ions Participate In Innate and Adaptive Immune Activat...mentioning

confidence: 99%

Metal ions and nanometallic materials in antitumor immunity: Function, application, and perspective

Shen

Fang

et al. 2023

J Nanobiotechnol

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The slightest change in the extra/intracellular concentration of metal ions results in amplified effects by signaling cascades that regulate both cell fate within the tumor microenvironment and immune status, which influences the network of antitumor immunity through various pathways. Based on the fact that metal ions influence the fate of cancer cells and participate in both innate and adaptive immunity, they are widely applied in antitumor therapy as immune modulators. Moreover, nanomedicine possesses the advantage of precise delivery and responsive release, which can perfectly remedy the drawbacks of metal ions, such as low target selectivity and systematic toxicity, thus providing an ideal platform for metal ion application in cancer treatment. Emerging evidence has shown that immunotherapy applied with nanometallic materials may significantly enhance therapeutic efficacy. Here, we focus on the physiopathology of metal ions in tumorigenesis and discuss several breakthroughs regarding the use of nanometallic materials in antitumor immunotherapeutics. These findings demonstrate the prominence of metal ion-based nanomedicine in cancer therapy and prophylaxis, providing many new ideas for basic immunity research and clinical application. Consequently, we provide innovative insights into the comprehensive understanding of the application of metal ions combined with nanomedicine in cancer immunotherapy in the past few years. Graphical Abstract

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“…Since zinc transporter 2 facilitates zinc import into PC granules, the ablation of this zinc transporter impairs PC functions and AMP secretion (75). Zinc supplementation alleviates PC necroptosis and intestinal microbiota disorder induced by TNF treatment in mice (76).…”

Section: Amp Secretionmentioning

confidence: 99%

From birth to death: The hardworking life of Paneth cell in the small intestine

et al. 2023

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Paneth cells are a group of unique intestinal epithelial cells, and they play an important role in host-microbiota interactions. At the origin of Paneth cell life, several pathways such as Wnt, Notch, and BMP signaling, affect the differentiation of Paneth cells. After lineage commitment, Paneth cells migrate downward and reside in the base of crypts, and they possess abundant granules in their apical cytoplasm. These granules contain some important substances such as antimicrobial peptides and growth factors. Antimicrobial peptides can regulate the composition of microbiota and defend against mucosal penetration by commensal and pathogenic bacteria to protect the intestinal epithelia. The growth factors derived from Paneth cells contribute to the maintenance of the normal functions of intestinal stem cells. The presence of Paneth cells ensures the sterile environment and clearance of apoptotic cells from crypts to maintain the intestinal homeostasis. At the end of their lives, Paneth cells experience different types of programmed cell death such as apoptosis and necroptosis. During intestinal injury, Paneth cells can acquire stem cell features to restore the intestinal epithelial integrity. In view of the crucial roles of Paneth cells in the intestinal homeostasis, research on Paneth cells has rapidly developed in recent years, and the existing reviews on Paneth cells have mainly focused on their functions of antimicrobial peptide secretion and intestinal stem cell support. This review aims to summarize the approaches to studying Paneth cells and introduce the whole life experience of Paneth cells from birth to death.

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Zinc inhibits lethal inflammatory shock by preventing microbe‐induced interferon signature in intestinal epithelium

Cited by 13 publications

References 61 publications

Crosstalk between regulated necrosis and micronutrition, bridged by reactive oxygen species

Crosstalk between regulated necrosis and micronutrition, bridged by reactive oxygen species

Metal ions and nanometallic materials in antitumor immunity: Function, application, and perspective

From birth to death: The hardworking life of Paneth cell in the small intestine

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