Zinc Ingestion and Lipoprotein Values in Sedentary and Endurance-Trained Men

Crouse, Stephen F.

doi:10.1001/jama.1984.03350060029023

Cited by 25 publications

(10 citation statements)

References 15 publications

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“…According to our data, a similar sex-dependent effect of Zn on TAG level was also reported in the SU.VI.MAX study with a multi-nutrient antioxidant supplementation containing 20 mg Zn (Hercberg et al 2005). Moreover, we did not report a negative effect of Zn supplementation on HDL status, consistent with the results of some (Crouse et al 1984;Fosmire, 1990;Hiller et al 1995;Bonham et al 2003;Hercberg et al 2005) but not all (Hooper et al 1980;Chandra, 1984;Chevalier et al 2002) studies. It seems that these results depend on the studied Zn intake, in particular when it is excessive, since in these studies, the adverse effects on HDL were described for pharmacological Zn supplementation at 50 mg/d (Black et al 1988;Chevalier et al 2002) or higher; 75 mg/d (Black et al 1988); 300 mg/d (Chandra et al 1984); 440 mg/d (Hooper et al 1980).…”

Section: Discussionsupporting

confidence: 92%

“…It seems that these results depend on the studied Zn intake, in particular when it is excessive, since in these studies, the adverse effects on HDL were described for pharmacological Zn supplementation at 50 mg/d (Black et al 1988;Chevalier et al 2002) or higher; 75 mg/d (Black et al 1988); 300 mg/d (Chandra et al 1984); 440 mg/d (Hooper et al 1980). Furthermore, men (Crouse et al 1984;Bonham et al 2003) seem to be more affected by Zn supplementation on HDL than women (Freeland-Graves et al 1982;Samman & Roberts, 1988). The mechanism by which Zn interferes with lipid metabolism is not clear but thought to be related to induced Cu deficiency (Scientific Committee of Food, 2003).…”

Section: Discussionmentioning

confidence: 86%

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Age- and sex-dependent effects of long-term zinc supplementation on essential trace element status and lipid metabolism in European subjects: the Zenith Study

et al. 2007

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Given the key role of Zn in many physiological functions, optimal Zn status could be a predictive parameter of successful ageing. However, the benefit of Zn supplementation is still a matter of debate since Zn supplementation has been reported to be associated with the alteration of Cu status and lipid metabolism. As part of the Zenith Project, the present study aimed to investigate, in free-living healthy European middle-aged and older subjects, the effect of Zn supplementation on the biochemical status of Zn, Fe and Cu and on lipid profile. Volunteers aged 55 -70 (n 188) and 70-85 (n 199) years old participated in a double-blinded, randomised study and received a daily placebo, or Zn as 15 or 30 mg for 6 months. Zn supplementation did not significantly modify erythrocyte Zn levels or erythrocyte Cu,Zn-superoxide dismutase activity. But Zn supplementation at 15 or 30 mg/d for 6 months increased significantly serum Zn levels and Zn urinary excretion with no major adverse effects on Fe and Cu status or on lipid metabolism. However, Zn supplementation at 30 mg/d showed some age-and sex-dependent alterations in Fe status or lipid profile. Therefore, with respect to the key role of an optimal Zn status in successful ageing, Zn supplementation at 15 mg/d, when necessary, could be safely proposed regarding lipids and the risk of interaction with Fe and Cu.Zinc supplementation: Zinc status: Trace element interactions: Trace element -lipid interactions: Elderly

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 86%

Age- and sex-dependent effects of long-term zinc supplementation on essential trace element status and lipid metabolism in European subjects: the Zenith Study

et al. 2007

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“…Another investigation was performed to examine the effect of oral zinc administration on human lipoprotein values. The sharp fall of the "antiatherogenic" lipoprotein HDL associated with zinc administration supports the concept that zinc ingestion may be atherogenic in man (10) and may increase the coronary artery disease risk (11). According to another group of researchers varying the amount of zinc in the diet did not produce significant changes in plasma total cholesterol, plasma free cholesterol, HDL cholesterol or HDL-apolipoprotein concentration (12).…”

mentioning

confidence: 72%

Total Blood Cholesterol, HDL-Cholesterol and Serum Zinc Levels in Cardiovascular Disease : Kalp-Damar Hastalıklarında Total Kan Kolesterol, HDLKolesterol ve Serum Çinko Düzeyleri

Güvendik¹,

Gönül²,

Söylemezoğlu³

1991

Ankara Universitesi Eczacilik Fakultesi Dergisi

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SUMMARYSerum zinc, total blood cholesterol and HDL-cholesterol levels were studied in male and female patients who suffer from cardiovascular diseases (CDV). There was an increase in total blood cholesterol and HDL-cholesterol and serum zinc levesl of patients compared to the controls. The difference was significant for total blood cholesterol (p < 0.001 for male and female), HDL-cholesterol (p < 0.05 for female and p < 0.001 for male) and serum zinc level (p < 0.05 for female and p < 0.001 for male). Because of the drug therapy HDLcholesterol levels of the patients were higher than control. These results show that high serum zinc level of patients is a risk factor for CVD as well as total blood cholesterol level. ÖZETBu çalışmada, kardiyovaskuler rahatsızlıkları olan kadın ve erkek hastalarda total kan kolesterolü, HDL-kolesterolu serum çinko düzey-leri ölçülmüştür. Total kan kolesterolü ile HDL kolesterolü ve serum çinko düzeylerinde kontrol gruplarına göre yükselme bulunmuştur. İlaç tedavisinde olmaları nedeniyle hastalarda HDL-kolesterol düzey-leri kontrollerden yüksek bulunmuştur. Sonuçlar, kolesterol düzeyi yanında çinko düzeyinin yükselmesin-de kardiyovaskuler hastalıklar yönünden bir risk oluşturduğunu gös-termektedir.

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“…3. Change in HDL cholesterol (mmol=L) by health status (2,22,24,25,44,57,60,68,71,86,90,100,155,177). Data systematically extracted from controlled trials show no overall significant effect of zinc supplementation on plasma HDL cholesterol concentrations when evaluated using a random effects model of meta-analysis (67).…”

Section: A Putative Role For Nutritional Zinc Supplementation In Cvdmentioning

confidence: 99%

Zinc and Redox Signaling: Perturbations Associated with Cardiovascular Disease and Diabetes Mellitus

Foster

Samman

2010

Antioxidants & Redox Signaling

132

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Cellular signal transduction pathways are influenced by the zinc and redox status of the cell. Numerous chronic diseases, including cardiovascular disease (CVD) and diabetes mellitus (DM), have been associated with impaired zinc utilization and increased oxidative stress. In humans, mutations in the MT-1A and ZnT8 genes, both of which are involved in the maintenance of zinc homeostasis, have been linked with DM development. Changes in levels of intracellular free zinc may exacerbate oxidative stress in CVD and DM by impacting glutathione homeostasis, nitric oxide signaling, and nuclear factor-kappa B-dependent cellular processes. Zinc ions have been shown to influence insulin and leptin signaling via the phosphoinositide 3′-kinase/Akt pathway, potentially linking an imbalance of zinc at the cellular level to insulin resistance and dyslipidemia. The oxidative modification of cysteine residues in zinc coordination sites in proteins has been implicated in cellular signaling and regulatory pathways. Despite the many interactions between zinc and cellular stress responses, studies investigating the potential therapeutic benefit of zinc supplementation in the prevention and treatment of oxidative stress-related chronic disease in humans are few and inconsistent. Further well-designed randomized controlled trials are needed to determine the effects of zinc supplementation in populations at various stages of CVD and DM progression.

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Zinc Ingestion and Lipoprotein Values in Sedentary and Endurance-Trained Men

Cited by 25 publications

References 15 publications

Age- and sex-dependent effects of long-term zinc supplementation on essential trace element status and lipid metabolism in European subjects: the Zenith Study

Age- and sex-dependent effects of long-term zinc supplementation on essential trace element status and lipid metabolism in European subjects: the Zenith Study

Total Blood Cholesterol, HDL-Cholesterol and Serum Zinc Levels in Cardiovascular Disease : Kalp-Damar Hastalıklarında Total Kan Kolesterol, HDLKolesterol ve Serum Çinko Düzeyleri

Zinc and Redox Signaling: Perturbations Associated with Cardiovascular Disease and Diabetes Mellitus

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