Zinc‐induced copper deficiency, sideroblastic anemia, and neutropenia: A perplexing facet of zinc excess

Wahab, Ahsan; Mushtaq, Kamran; Borak, Samuel G.; Bellam, Naresh

doi:10.1002/ccr3.2987

Cited by 25 publications

(24 citation statements)

References 23 publications

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“…Heavy metal toxicity, specifically from lead poisoning or zinc overdose is associated with SA. Excess exposure to zinc can cause SA by competing with iron incorporation into protoporphyrin and preventing intestinal absorption of copper through induction of an intestinal metal-binding protein metallothionein [13].…”

Section: Discussionmentioning

confidence: 99%

Recurrent sideroblastic anaemia during pregnancy

Fareed

Ibrahim

Alasafar

et al. 2022

Preprint

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Section: Discussionmentioning

confidence: 99%

Recurrent sideroblastic anaemia during pregnancy

Fareed

Ibrahim

Alasafar

et al. 2022

Preprint

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“…In several small studies, zinc gluconate showed promising results in mild-to-moderate HS [ 64 , 65 , 66 ]. As zinc competes with copper in gastrointestinal resorption, long-term use of high doses of zinc may cause hypocupremia and anemia; thus, routine monitoring of copper levels and hemoglobin is recommended [ 67 ]. Gastrointestinal discomfort is a frequent reported side effect.…”

Section: Treatmentmentioning

confidence: 99%

Current Medical and Surgical Treatment of Hidradenitis Suppurativa—A Comprehensive Review

Ocker

Rached

Seifert

et al. 2022

JCM

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Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease presenting with recurrent inflammatory lesions in intertriginous body regions. HS has a pronounced impact on patients’ quality of life and is associated with a variety of comorbidities. Treatment of HS is often complex, requiring an individual approach with medical and surgical treatments available. However, especially in moderate-to-severe HS, there is an urgent need for new treatment approaches. In recent years, increased research has led to the identification of new potential therapeutic targets. This review aims to give a comprehensive and practical overview of current treatment options for HS. Furthermore, the clinically most advanced novel treatment approaches will be discussed.

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“…Ceruloplasmin is a ferroxidase that helps to convert ferrous to ferric iron, allowing it to bind transferrin and be transported throughout the body. The enzyme cytochrome oxidase, which is copper-dependent, is required for the reduction of ferric iron and incorporating it into the Heme molecule [ 82 , 83 , 84 ]. Copper deficiency can develop hematological abnormalities, and it might mimic myelodysplastic syndromes [ 85 , 86 , 87 , 88 , 89 ].…”

Section: Non-clonal or Metabolic Acquired Sideroblastic Anemiasmentioning

confidence: 99%

Causes and Pathophysiology of Acquired Sideroblastic Anemia

Rodríguez‐Sevilla

Calvo

Arenillas

2022

Genes

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The sideroblastic anemias are a heterogeneous group of inherited and acquired disorders characterized by anemia and the presence of ring sideroblasts in the bone marrow. Ring sideroblasts are abnormal erythroblasts with iron-loaded mitochondria that are visualized by Prussian blue staining as a perinuclear ring of green-blue granules. The mechanisms that lead to the ring sideroblast formation are heterogeneous, but in all of them, there is an abnormal deposition of iron in the mitochondria of erythroblasts. Congenital sideroblastic anemias include nonsyndromic and syndromic disorders. Acquired sideroblastic anemias include conditions that range from clonal disorders (myeloid neoplasms as myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms with ring sideroblasts) to toxic or metabolic reversible sideroblastic anemia. In the last 30 years, due to the advances in genomic techniques, a deep knowledge of the pathophysiological mechanisms has been accomplished and the bases for possible targeted treatments have been established. The distinction between the different forms of sideroblastic anemia is based on the study of the characteristics of the anemia, age of diagnosis, clinical manifestations, and the performance of laboratory analysis involving genetic testing in many cases. This review focuses on the differential diagnosis of acquired disorders associated with ring sideroblasts.

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Zinc‐induced copper deficiency, sideroblastic anemia, and neutropenia: A perplexing facet of zinc excess

Abstract: Hypocupremia due to zinc products can cause sideroblastic anemia and neutropenia and mimics other serious hematological disorders. Early consideration of the copper deficiency and a thorough clinical history can prevent unnecessary interventions.

Cited by 25 publications

References 23 publications

Recurrent sideroblastic anaemia during pregnancy

Recurrent sideroblastic anaemia during pregnancy

Current Medical and Surgical Treatment of Hidradenitis Suppurativa—A Comprehensive Review

Causes and Pathophysiology of Acquired Sideroblastic Anemia

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