Zinc in Postmortem Body Tissues and Fluids

Lech, Teresa; Sadlik, Józefa Krystyna

doi:10.1007/s12011-010-8747-5

Cited by 21 publications

(13 citation statements)

References 25 publications

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“…The MT bound fraction is later returned to the bowel during shedding of enterocytes. Zn is efficiently excreted into bile at a concentration of around 4 µg/mL 13 . Some of the secreted Zn is reabsorbed, undergoing an enterohepatic circulation, the net gastrointestinal (GI) loss being 2–4 mg/d.…”

Section: Physiologymentioning

confidence: 99%

Zinc

Livingstone

2015

Nut in Clin Prac

222

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The essential trace element zinc (Zn) has a large number of physiologic roles, in particular being required for growth and functioning of the immune system. Adaptive mechanisms enable the body to maintain normal total body Zn status over a wide range of intakes, but deficiency can occur because of reduced absorption or increased gastrointestinal losses. Deficiency impairs physiologic processes, leading to clinical consequences that include failure to thrive, skin rash, and impaired wound healing. Mild deficiency that is not clinically overt may still cause nonspecific consequences, such as susceptibility to infection and poor growth. The plasma Zn concentration has poor sensitivity and specificity as a test of deficiency. Consequently, diagnosis of deficiency requires a combination of clinical assessment and biochemical tests. Patients receiving parenteral nutrition (PN) are susceptible to Zn deficiency and its consequences. Nutrition support teams should have a strategy for assessing Zn status and optimizing this by appropriate supplementation. Nutrition guidelines recommend generous Zn provision from the start of PN. This review covers the physiology of Zn, the consequences of its deficiency, and the assessment of its status, before discussing its role in PN.

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Section: Physiologymentioning

confidence: 99%

Zinc

Livingstone

2015

Nut in Clin Prac

222

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“…The concentration of zinc in human tissues varies dramatically, ranging from 10 μ g/g (lungs) to 83.2 μ g/g (liver). In body fluids, the zinc concentration ranges from 0.2 to 8.7 μ g/mL (Lech and Sadlik, 2011). Thus, pathogenic fungi have developed efficient strategies to uptake zinc to overcome the limits imposed by host.…”

Section: Fungal Zinc Uptakementioning

confidence: 99%

Fungal zinc metabolism and its connections to virulence

Staats

Kmetzsch

Schrank

et al. 2013

Front. Cell. Infect. Microbiol.

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Zinc is a ubiquitous metal in all life forms, as it is a structural component of the almost 10% of eukaryotic proteins, which are called zinc-binding proteins. In zinc-limiting conditions such as those found during infection, pathogenic fungi activate the expression of several systems to enhance the uptake of zinc. These systems include ZIP transporters (solute carrier 39 family) and secreted zincophores, which are proteins that are able to chelate zinc. The expression of some fungal zinc uptake systems are regulated by a master regulator (Zap1), first characterized in the yeast Saccharomyces cerevisiae. In this review, we highlight features of zinc uptake and metabolism in human fungal pathogens and aspects of the relationship between proper zinc metabolism and the expression of virulence factors and adaptation to the host habitat.

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“…In relation to AD, the fact that Ab can be formed in both intracellular and ECM environments and that those disturbances to the balance of multivalent cations have already been observed in AD supports this hypothesis. 3,6,88,90,174,175,178,180,[182][183][184][185][186] We would encourage researchers, in the context of various experimental approaches to dissect the underlying mechanisms of AD, and to also consider the simultaneous measurement of cations. In doing so, they should explore the nature of possible associations between cation levels and Ab misfolding, levels in the ECM, and dysregulation of corresponding signaling pathways in the intracellular environment.…”

Section: Future Perspectives-application Of Nanotechnology Principlesmentioning

confidence: 99%

Interdisciplinary challenges and promising theranostic effects of nanoscience in Alzheimer's disease

et al. 2012

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During the last decade, reports show that the incidence and prevalence of Alzheimer's disease (AD) and other dementias have significantly increased. AD poses an enormous escalating threat to health services and resources. Early diagnosis of AD is recognized as one of the major challenges and primary aims in scientific communities. With the arrival of nanoscience and nanotechnology to medicine, hopes for early diagnosis and treatment of AD have considerably increased. To this end, nanobioresearchers are focused on three major areas consisting of early detection and recognition, biological markers and diagnosis, and pharmacotherapy. Several efforts are in progress for the discovery of new nanodrugs with a sufficient effort on the fast therapy of AD. In this review, a comprehensive overview of the conventional theories together with new conflicts and challenges on the major causes of AD is provided. In addition, the opportunities and challenges of nanoscience and nanotechnology as theranostic agents for AD are discussed in detail.

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Zinc in Postmortem Body Tissues and Fluids

Cited by 21 publications

References 25 publications

Zinc

Zinc

Fungal zinc metabolism and its connections to virulence

Interdisciplinary challenges and promising theranostic effects of nanoscience in Alzheimer's disease

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