Zinc in patients with chronic renal failure

Piechota, Wiesław; Dobrucki, Tomasz; Symonowicz, N; Wadowska, Elzbieta; Murkowska, Ewa

doi:10.1007/bf02082558

Cited by 10 publications

(3 citation statements)

References 21 publications

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“…Some investigators have reported a reduction [13,14] and others acute toxicity or increased levels of essential trace elements in hemodialysis patients [15][16][17]. Such discrepant discussion was present also in a review article by Tonelli et al [2].…”

Section: Discussionmentioning

confidence: 98%

Determining Serum Zinc and Magnesium Levels in Hemodialysis Patients Could be Helpful for Clinicians

et al. 2016

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Trace element determination is requested rarely for critically ill patients in Iran, due to the underestimation of the trace element determination by Iranian physicians. The aim was to compare the levels of Zn and Mg in a group of hemodialysis patients and normal individuals. This study shows that trace element determination is helpful for management of hemodialysis patients. Fifty-three hemodialysis patients and 51 control individuals were randomly analyzed for Zn and Mg serum levels. Comparison of before or after dialysis and with normal individuals was done and receiver operating characteristics (ROC) curves were plotted to evaluate the analytical sensitivity and specificity of Zn and Mg determination. Confidence interval for all statistical methods was 95 %. Zinc serum levels were decreased after hemodialysis insignificantly ( = 0.201) but Mg levels were decreased significantly ( = 0.000). Both Zn and Mg levels, before and after hemodialysis were meaningfully lower than normal controls ( < 0.05). ROC analysis showed that the area under the curve was high for Zn levels both before and after hemodialysis but it was high for Mg only before hemodialysis. Current study shows that serum Zn and Mg measurements can have clinical importance. Both before and after hemodialysis, serum Zn = 297.5 µg/L and Mg = 2.295 µg/L are proposed as cut-off values with about 90 % specificity, for monitoring of these two element in hemodialysis patients. It is suggested that clinicians consider the measurement of these trace elements for hemodialysis patients routinely or periodically as clinical chemistry tests.

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Section: Discussionmentioning

confidence: 98%

Determining Serum Zinc and Magnesium Levels in Hemodialysis Patients Could be Helpful for Clinicians

et al. 2016

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“…This discrepancy can be as a result of the population's heterogenic nature or measurement technique sensitivity differences. Piechota and colleges have reported insignificant differences between ESRD patients and healthy group for Zn and Cu plasma levels but Mg level was higher in patients than control individuals [15]. Mansouri and his cooperators reported normal concentrations of Zn in uremic patients [16].…”

Section: Discussionmentioning

confidence: 98%

Comparison of zinc, copper, selenium, magnesium, aluminium and lead blood concentrations in end-stage renal disease patients and healthy volunteers in Ahvaz, southwest of Iran

Shahbazian¹,

Absalan²,

Jalali³

et al. 2018

Russ Open Med J

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Introduction-Heavy metal storage and essential elements deficiency are two important issues in dialysis patients. Geographic region and dietary habits might affect essential trace elements concentration in body. Trace elements (TEs) status has not been studied previously in dialyzed patients in Ahvaz city. The aim of this study is to compare blood concentrations of six TEs between dialysis patients and normal group in Ahvaz, the center of Khuzestan province, in southwest of Iran. Material and Methods-We studied 33 end-stage renal disease (ESRD) patients and 33 normal cases. TEs assayed in serum samples, except lead, which assessed in whole blood. We used atomic absorption spectroscopy in this pressure. We used ANOVA and Tukey-HSD statistical analysis as well as binary logistic regression for calculating Odds ratio. Results-There was a significant difference between case and control groups for magnesium (Mg), aluminium (Al) and lead (Pb) (P<0.05), but there was not a significant difference for copper (Cu) and selenium (Se) (P>0.05). Zinc (Zn) level change was not significant. Al and Pb level increased after dialysis but Mg level decreased. All calculated Odds ratios were weak for all investigated trace elements. Different results published about TEs level in ESRD patients. Increase in TEs level in case group may be as a result of chronic poisoning through dialysis and after dialysis hemoconcentration, respectively. In order to understand the exact reason of this observation we need comprehensive and monitored studies. TEs disturbances in Ahvaz ESRD patients imply the importance of periodically studies. Conclusion-The most important interpretations and suggestions of this study is that the TEs level is different among different population. Then, Iranian health-providers should consider to TEs assessment in both healthy and patient cases. Periodical measurement of TEs is essential for ESRD patients and it can be helpful in preventing TEs deleterious effects.

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“…Plasma and serum levels of copper in patients with renal failure were reported to be high [12,30] or normal [8,[87][88][89][90]. Serum copper tends to be generally low in patients treated by HD and CAPD [21,35,91].…”

Section: Coppermentioning

confidence: 99%

Trace Elements in End-Stage Renal Disease

Zima¹,

Tesař²,

Mestek

et al. 1999

Blood Purif

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For human beings trace elements are essential nutrients with a gamut of functions. They are for instance indispensable components of many enzymes, so they have some regulatory functions and they may affect immune reactions and free radical generation. Abnormalities of trace elements are primarily the result of uremia, and they may be further modified and sometimes greatly exacerbated by the dialysis procedure. The role of trace elements in hemodialysis (HD) patients has not yet been fully characterized. To prevent some complications in chronic HD patients, it is very important to regulate the levels of trace elements by adequate water treatment. Reverse osmosis is able to prevent the accumulation of the majority of trace elements in the patients. Zinc supplementation may be recommended for patients with proven zinc deficiency, but for all chronic renal failure patients it is questionable. Selenium deficiency is to be suspected in dialyzed patients and selenium supplementation may be beneficial (increasing glutathione peroxidase activity, cardioprotective effect, immunostimulatory properties) for chronic renal failure patients. Supplementation with a trace element may be indicated when its depletion was unequivocally documented and when there is evidence of the positive effects of this element on the quality of life of the dialyzed patients.

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Zinc in patients with chronic renal failure

Cited by 10 publications

References 21 publications

Determining Serum Zinc and Magnesium Levels in Hemodialysis Patients Could be Helpful for Clinicians

Determining Serum Zinc and Magnesium Levels in Hemodialysis Patients Could be Helpful for Clinicians

Comparison of zinc, copper, selenium, magnesium, aluminium and lead blood concentrations in end-stage renal disease patients and healthy volunteers in Ahvaz, southwest of Iran

Trace Elements in End-Stage Renal Disease

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