Zinc in calcium phosphate mediates bone induction: In vitro and in vivo model

Luo, Xiaoman; Barbieri, Davide; Davison, Noel; Yan, Yonggang; Bruijn, Joost D. de; Yuan, Huipin

doi:10.1016/j.actbio.2013.10.011

Cited by 140 publications

(87 citation statements)

References 43 publications

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“…Luo et al reported that Zn-containing tricalcium phosphate induced a great amount of new bone formation in the paraspinal muscle of canines. 26 The mechanism by which Zn influenced the osteogenic differentiation of the rBMSCs was beyond the scope of the present work. However, recent studies reported that Zn transporter-mediated Zn ions behaving as a signaling factor called Zn signal may play a crucial role in cellular events involving bone homeostasis.…”

Section: Yu Et Almentioning

confidence: 99%

“…[20][21][22] Therefore, Zn has been introduced into various biomaterials with a view to improve their bone-forming ability. Indeed, Zn-incorporated bioactive glasses, 23 coatings, 24,25 and calcium phosphate (CaP) 26 showed enhanced osteoinductive potential. However, the development of Zn-incorporated hydroxyapatite/collagen composite scaffolds has not yet been reported, and the effects of Zn on the biological responses of the composite scaffolds remain to be investigated.…”

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confidence: 99%

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Evaluation of zinc-doped mesoporous hydroxyapatite microspheres for the construction of a novel biomimetic scaffold optimized for bone augmentation

Sun

et al. 2017

IJN

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Biomaterials with high osteogenic activity are desirable for sufficient healing of bone defects resulting from trauma, tumor, infection, and congenital abnormalities. Synthetic materials mimicking the structure and composition of human trabecular bone are of considerable potential in bone augmentation. In the present study, a zinc (Zn)-doped mesoporous hydroxyapatite microspheres (Zn-MHMs)/collagen scaffold (Zn-MHMs/Coll) was developed through a lyophilization fabrication process and designed to mimic the trabecular bone. The Zn-MHMs were synthesized through a microwave-hydrothermal method by using creatine phosphate as an organic phosphorus source. Zn-MHMs that consist of hydroxyapatite nanosheets showed relatively uniform spherical morphology, mesoporous hollow structure, high specific surface area, and homogeneous Zn distribution. They were additionally investigated as a drug nanocarrier, which was efficient in drug delivery and presented a pH-responsive drug release behavior. Furthermore, they were incorporated into the collagen matrix to construct a biomimetic scaffold optimized for bone tissue regeneration. The Zn-MHMs/Coll scaffolds showed an interconnected pore structure in the range of 100–300 μm and a sustained release of Zn ions. More importantly, the Zn-MHMs/Coll scaffolds could enhance the osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells. Finally, the bone defect repair results of critical-sized femoral condyle defect rat model demonstrated that the Zn-MHMs/Coll scaffolds could enhance bone regeneration compared with the Coll or MHMs/Coll scaffolds. The results suggest that the biomimetic Zn-MHMs/Coll scaffolds may be of enormous potential in bone repair and regeneration.

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Section: Yu Et Almentioning

confidence: 99%

mentioning

confidence: 99%

Evaluation of zinc-doped mesoporous hydroxyapatite microspheres for the construction of a novel biomimetic scaffold optimized for bone augmentation

Sun

et al. 2017

IJN

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“…Zn in a similar way as Mg promotes bone formation and its deficiency in the body is associated with the decrease of bone density. Furthermore, Zn influences crystallinity and morphology of biological apatite crystals [97,99].…”

Section: Calcium Phosphatesmentioning

confidence: 99%

“…It is recognized that the introductions of ions like strontium (Sr) [93][94][95][96], magnesium (Mg) [94,96], manganese (Mn) [7,95,96] or zinc [97,98] in a single or combined way play a fundamental role in bone development. Sr is present in bone in considerable amounts and, in particular at regions of elevated metabolic turnover [92,96].…”

Section: Calcium Phosphatesmentioning

confidence: 99%

Synthetic and Marine-Derived Porous Bone Graft Substitutes

Neto¹,

Ferreira²

2018

Preprint

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Bone is a dynamic tissue with the capacity of repair and regeneration in specific conditions. Nevertheless, due to the increased incidence of bone disorders, the need of bone grafts has been growing over the past decades and the development of a bone graft with optimal properties remains a clinical challenge. This review addresses the bone properties (morphology, composition and their repair and regeneration capacity) and then is focused on the potential strategies for bone repair and regeneration. It describes the requirements for designing a suitable scaffold material, types of materials (polymers, ceramics and composites) and techniques to obtain the porous structures (additive manufacturing techniques/robocasting or derived from marine skeletons) for bone tissue engineering applications. The main objective of this review is to gather the knowledge on the materials and methods for the production of scaffolds for bone tissue engineering and highlight that natural materials, namely the marine skeletons represent a promising alternative.

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“…While it's slow biodegradability in situ allows tissue regeneration and tissue replacement to take place [3,11,12]. These properties are of particular importance since bone continually undergoes cellular remodeling and as a result tissue is simultaneously deposited by osteoblasts cells and removed by osteoclasts cells [3,13]. It is due to the advantageous bioactive properties of HAP that has made it a successful biomaterial for a number of clinical applications such as dental repair procedures, repairing bone defects, bone augmentation and coatings on metallic implants [14,15].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of a Hydroxyapatite Nanopowder via Ultrasound Irradiation from Calcium Hydroxide Powders for Potential Biomedical Applications

Brundavanam¹,

Poinern²,

Fawcett³

2015

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Nanoscale hydroxyapatite based ceramics are a relatively new form of materials that are currently being investigated for a number of potential biomedical applications. This study reports on a straightforward wet chemical method that uses calcium hydroxide and phosphoric acid as precursors. After chemical synthesis a conventional thermal treatment was used to produce an ultrafine hydroxyapatite nanopowder. Varying ultrasonic power between zero and 400 W during the synthesis process produced crystallite sizes ranging from 15.4 nm down to 12.2 nm. The morphology of particles synthesized under the influence of ultrasonic irradiation was predominantly spherical and granular. Also present were a small number of irregular shaped plates. Energy dispersive spectroscopy revealed the samples had a Ca:P ratio of 1.66, which was very close to the ideal value of 1.67. FT-IR studies identified functional groups and confirmed the results of the X-ray diffraction data that the powders were indeed composed of nanoscale hydroxyapatite.

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Zinc in calcium phosphate mediates bone induction: In vitro and in vivo model

Cited by 140 publications

References 43 publications

Evaluation of zinc-doped mesoporous hydroxyapatite microspheres for the construction of a novel biomimetic scaffold optimized for bone augmentation

Evaluation of zinc-doped mesoporous hydroxyapatite microspheres for the construction of a novel biomimetic scaffold optimized for bone augmentation

Synthetic and Marine-Derived Porous Bone Graft Substitutes

Synthesis of a Hydroxyapatite Nanopowder via Ultrasound Irradiation from Calcium Hydroxide Powders for Potential Biomedical Applications

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