Zinc improves sexual performance and erectile function by preventing penile oxidative injury and upregulating circulating testosterone in lead-exposed rats

Besong, Elizabeth Enohnyket; Akhigbe, Tunmise Maryanne; Ashonibare, Precious Jesutofunmi; Oladipo, Abimbola Ayoola; Obimma, Jacinta Nkechi; Hamed, Moses Agbomhere; Adeyemi, Damilare Hakeem; Akhigbe, Roland Eghoghosoa

doi:10.1080/13510002.2023.2225675

Cited by 12 publications

(4 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These hormones stimulate the release of neurotransmitters, such as dopamine, which, in turn, increase locomotor activity and contribute to improved copulatory and sexual performance. During mating and sexual encounters, the circulation of testosterone in the body enhances sexual desire, motivation, and overall sexual function [30,31]. As illustrated in Table 3, the rats treated with sildenafil, ginseng, and MJ Cr.…”

Section: Resultsmentioning

confidence: 99%

Evaluating the Aphrodisiac Potential of Mirabilis jalapa L. Root Extract: Phytochemical Profiling and In Silico, In Vitro, and In Vivo Assessments in Normal Male Rats

Rahman,

Alam,

Khan

et al. 2023

Molecules

View full text Add to dashboard Cite

The traditional use of Mirabilis jalapa L. roots to enhance male sexual performance prompted us to assess the in silico, in vitro, and in vivo aphrodisiac activities of its hydroethanolic extract using normal male rats. Spectroscopic characterization indicated the presence of ß-D-glucopyranoside, methyl-1,9-benzyl-2,6-dichloro-9H-purine, and Bis-(2-ethylhexyl)-phthalate; these compounds have a significant inhibitory effect on the phosphodiesterase-5 (PDE-5) enzyme in silico evaluation and minerals (including zinc, cadmium, and magnesium). Other phytochemical analyses revealed the presence of phenolic compounds and flavonoids. These phytochemicals and minerals may contribute to the aphrodisiac activities of the extract. Additionally, the in vivo study revealed that the administration of M. jalapa root extract (300 mg/kg) significantly enhanced (p < 0.01, p < 0.03) mount, intromission, and ejaculation frequencies while significantly (p < 0.05) decreasing the mount and intromission latencies, as well as the post-ejaculatory interval time, in comparison with the standard drugs sildenafil and ginseng, resulting in enhanced erection and sexual performance in the rats. Furthermore, the extract significantly (p < 0.05) increased penile reflexes and also elevated the levels of testosterone and luteinizing hormones. Extract (300 mg/kg) significantly (p < 0.05) inhibited the PDE-5 enzyme in an in vitro study. Concludingly, the comprehensive findings of this study suggest that a standardized herbal extract derived from M. jalapa roots alleviates erectile dysfunction and premature ejaculation in male rats. M. jalapa root extract proved to be an alternative treatment for erectile dysfunction and premature ejaculation.

show abstract

Section: Resultsmentioning

confidence: 99%

Evaluating the Aphrodisiac Potential of Mirabilis jalapa L. Root Extract: Phytochemical Profiling and In Silico, In Vitro, and In Vivo Assessments in Normal Male Rats

Rahman,

Alam,

Khan

et al. 2023

Molecules

View full text Add to dashboard Cite

show abstract

“…Besong et al and Rafique et al reached similar conclusions regarding the positive effect of Zn on maintaining optimal testosterone levels. Additionally, Trumbo et al's study suggests that increasing dietary Zn intake within the recommended range may be beneficial in reducing the risk of erectile dysfunction [7,42,43]. An animal study conducted in 2009 demonstrated that rats receiving 5 milligrams per day of Zn supplementation exhibited improved sexual function, with similar positive effects observed in men, emphasizing the potential of Zn in arousal and erection maintenance [44].…”

Section: Discussionmentioning

confidence: 99%

Concentrations of Bioelements (Zn, Cu, Fe, Cr, Mg, Mn) in Serum and Bone Tissue of Aging Men Undergoing Hip Arthroplasty: Implications for Erectile Dysfunction

Rył,

Ciosek,

Szylińska

et al. 2024

Biomolecules

View full text Add to dashboard Cite

Background: Erectile dysfunction (ED) stands out as one of the most prevalent sexual disorders in men, with its incidence progressively escalating with age. As delineated by the International Consultation Committee for Sexual Medicine on Definitions/Epidemiology/Risk Factors for Sexual Dysfunction, the prevalence of ED among men under 40 years is estimated to be within the range of 1–10%. The aim of this study was to determine the relationship between the concentration of bioelements (Zn, Cu, Fe, Cr, Mg, and Mn) in the serum and bone tissue and the concentration of selected hormones in men with and without erectile dysfunction. Materials and methods: The retrospective cohort study included 152 men who underwent total hip arthroplasty for hip osteoarthritis at the Department of Orthopaedic Traumatology and Musculoskeletal Oncology at the Pomeranian Medical University in Szczecin. Certain exclusion criteria were applied to ensure the integrity of the study. These included individuals with diabetes, a history of cancer, alcohol abuse, liver or kidney failure, New York Heart Association (NYHA) class III or IV heart failure, and those taking medications that affect bone metabolism, such as mineral supplements, neuroleptics, chemotherapeutic agents, immunosuppressants, corticosteroids, or antidepressants. Patients with hypogonadism or infertility were excluded from the study. Results: The study showed an association between bioT concentrations and Cu concentrations in both patients with and without erectile dysfunction. A correlation between bioactive testosterone and Cr concentrations was also observed in both groups. Patients with erectile dysfunction showed a relationship between bioT concentration and Zn concentration, TT concentration and Mn concentration, FT concentration and Zn concentration, and E2 concentration and Cr concentration. An analysis of elemental concentrations in bone tissue showed an association between FT and Mg and Mn concentrations, but only in patients with erectile dysfunction. In patients without erectile dysfunction, a correlation was observed between FT and Cu concentrations. A correlation was also observed between bioT concentrations and Mg, Mn, and Zn concentrations, but only in patients with erectile dysfunction. In patients without erectile dysfunction, a correlation was observed between bioT and Cu concentrations. Conclusions: Studying the relationship between the concentration of bioelements (Zn, Cu, Fe, Cr, Mg, and Mn) in the serum and bone tissue and the concentration of selected hormones in men may be important in explaining the etiology of the problem. The study of the concentration of Zn and Cu in bone tissue and serum showed that these two elements, regardless of the place of accumulation, may be related to the concentration of androgens in men.

show abstract

“…A clinical study showed that changes in lipid levels can affect the secretion of reproductive hormones T, FSH, and LH, with T being the most serious [22]. Testosterone is an important hormone for the maintenance of male characteristics and has a very important role in spermatogenesis and development as well as in the maintenance of sexual function and is involved in a variety of physiological pathways in men [23][24][25]. Reduced testosterone levels can lead to disorders in spermatogenesis, which in turn reduces the total number of spermatozoa.…”

Section: Discussionmentioning

confidence: 99%

Hyperlipidemia Is Not Related to Semen Quality, but to Serum Testosterone Levels

Bi,

Ma,

Yang

et al. 2024

Andrologia

View full text Add to dashboard Cite

Background. Currently, there are few studies on the effects of hyperlipidemia on semen parameters and serum hormones in men. In this study, we divided the study subjects into two groups of normal and hyperlipidemia according to the criteria, and observed the differences between semen parameters and serum reproductive hormones in hyperlipidaemic men and normal men, to explore the potential associations between the indicators. Materials and Methods. Eight hundred eighty five men attending infertility clinics in six hospitals from September 2016 to June 2017 were selected. Their lipid levels, semen parameters, and serum reproductive hormone levels were tested, and a total of 480 men with normal lipids and 405 men with hyperlipidemia were selected according to the criteria, and the relationship between semen quality, serum reproductive hormones, lipids and semen parameters, and serum hormones was statistically analyzed. Results. There was no significant difference in semen parameters between hyperlipidaemic men and normal men (P >0.05), serum testosterone levels were significantly lower in hyperlipidaemic men (P <0.05), and there was a negative correlation between triglycerides (TG) and testosterone in the blood (P <0.05).Conclusion. Hyperlipidemia does not affect male semen parameters, and changes in testosterone in hyperlipidaemic men may be related to triglycerides.

show abstract

Zinc improves sexual performance and erectile function by preventing penile oxidative injury and upregulating circulating testosterone in lead-exposed rats

Cited by 12 publications

References 74 publications

Evaluating the Aphrodisiac Potential of Mirabilis jalapa L. Root Extract: Phytochemical Profiling and In Silico, In Vitro, and In Vivo Assessments in Normal Male Rats

Evaluating the Aphrodisiac Potential of Mirabilis jalapa L. Root Extract: Phytochemical Profiling and In Silico, In Vitro, and In Vivo Assessments in Normal Male Rats

Concentrations of Bioelements (Zn, Cu, Fe, Cr, Mg, Mn) in Serum and Bone Tissue of Aging Men Undergoing Hip Arthroplasty: Implications for Erectile Dysfunction

Hyperlipidemia Is Not Related to Semen Quality, but to Serum Testosterone Levels

Contact Info

Product

Resources

About