Zinc(II) complexes of 2-acetyl pyridine 1-(4-fluorophenyl)-piperazinyl thiosemicarbazone: Synthesis, spectroscopic study and crystal structures – Potential anticancer drugs

Synthesis, characterization and cytotoxicity of Pt(II), Pd(II), Cu(II) and Zn(II) complexes with 4’‐substituted terpyridine

“…Peaks of Pd(II) complex 2 at 244 and 278 nm were assigned to the π–π * IL transition and the 349 and 365 nm absorptions were assigned to MLCT transition . The bands of Cu(II) and Zn(II) complexes ( 3 , 4 , 5 , 6 , 7 , 8 ) between 223 and 286 nm were assigned to IL transition and 326–334 nm absorption bands were assigned to MLCT transition . The red shift indicated that the metal coordinated with the ligand through nitrogen atoms.…”

“…The synthesis of new Zn(II) complexes, study of their pharmacological properties and their screening as antitumor agents constitute a matter of current interest . Stanojkovic et al . reported several zinc(II) complexes based on 2‐acetylpyridine thiosemicarbazone derivatives, with IC 50 values ranging from 26 to 90 n m , against HeLa (cervical adenocarcinoma), K562 (chronic myelogenous leukemia), and MDA‐MB‐361 and MDA‐MB‐453 (breast cancer) cell lines.…”

“…Metal complexes of tpy can efficiently intercalate into nucleic acid to be effectively performed as potential antitumor agents . Modification of tpy generated a variety of derivatives and structural variation of tpy may have a significant impact on the antitumor activity of their complexes . In order to further explore the structure–activity relationships and discover new metal‐based anticancer drugs, the synthesis, characterization and cytotoxicity of eight new metal (Pt(II), Pd(II), Cu(II) and Zn(II)) complexes with 4’‐substitued tpy are described in the present work for the first time.…”

Synthesis, structure and antioxidant activity of (tetra-O-acetyl-β-D-galactopyranosyl)thiosemicarbazones of substituted benzaldehydes

“…Thiosemicarbazones can be used for making complex formation of metallic ions[4–13]. Thiosemicarbazones exhibit various biological activities such as antituberculosis[1415], antimicrobial[916–18], antiinflammatory[19], anticonvulsant[920], antihypertensive[21], local anesthetic[22], anticancer[1023], hypoglycemic[24], and cytotoxic activities[9], also antioxidant agents[1125]. A number of galactosyl thiosemicarbazide derivatives showed significant in vivo antimicrobial and in vitro antioxidant activity, which could be used as leads for the development of effective antiatherosclerotic agents[2202627].…”

2-(Carboxymethylsulfanyl)pyridine-3-carboxylic acid monohydrate

“…Comment Thiosemicarbazones and their metal complexes attract constant scientific interest due to their antimicrobial, antifungal and antitumoral activities (Garoufilis et al, 2009;Stanojkovic et al, 2010). Moreover, some thiosemicarbazones are used as reagents for determination of Co(II), Ni(II), Cu(II) and Pd(II) by solid phase microextraction in HPLC (Kaur et al, 2007).…”