Zinc(II) complexes derived from ibuprofen Schiff base ligands: synthesis, characterization and biological activity

Abstract

The produced Ibuprofen derivative, Ibuprofen hydrazide and 2-hydroxy-1-naphthaldhyde to form HL 1 and Ibuprofen hydrazide and 5-bromosalicylaldehyde to form HL 2 ligand, was reacted with Zn(II) ions complexes under experimental conditions to produce the ZnL 1 and ZnL 2 complexes. The ligands and their complexes were characterised using elemental analyses (C,H,N), FT-IR, electronic spectra, magnetic moments, molar ratio measurements, and molar conductance tests. The in-vitro cytotoxic activity of the new ligand and their complexes was also investigated against colon cancer cells (HCT-116 cell line), breast cancer cells (MCF-7 cell line), and hepatic cancer cells (MCF-8 cell line). Ibuprofen Schiff base ligands and their complexes wer tested in-vitro against bacterial pathogens and fungi. Synthetic compounds and the conventional antibiotic Gentamycin were tested in vitro against two Gram positive bacteria (S. aureus and B. subtilis) and two Gram negative bacteria (E. coli and P. vulgaris). In vitro antifungal potency, the new Schiff base ligands and their complexes were tested against two fungus, C. albicans and A. fumigatus, and compared to Ketoconazole, a common antifungal drug.