Zinc(II), cadmium(II) and mercury(II) complexes of the vitamin B1 antagonist oxythiamine

Casas, José S.; Castellano, Eduardo E.; Couce, Marı́a D.; Ellena, Javier; Sánchez, Agustı́n; Sordo, José; Taboada, Cristina

doi:10.1016/j.jinorgbio.2005.10.009

Cited by 53 publications

(16 citation statements)

References 28 publications

(36 reference statements)

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“…2). It's known that mercury (Hg ?2 ) interact with thiamine only at the N1 site of the pyrimidine moiety at pH 6 (Casas et al 2006). Therefore, it is possible that Pb and Hg perhaps share common binding site on the pyrimidine ring of thiamine.…”

Section: Resultsmentioning

confidence: 99%

Thiamine reduces tissue lead levels in rats: mechanism of interaction

2009

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Lead (Pb) toxicity has been a serious concern in industrialized societies because of its association with functional deficits in nervous, haematopoietic and renal systems. Several studies have shown beneficial effects of thiamine on Pb toxicity. It is speculated that Pb chelation by thiamine may be a possible mechanism. However, the exact nature of these interactions remained elusive. In the present study we have characterized the interaction of Pb with thiamine using UV-Vis as well as fluorescence spectroscopic methods and studied the effect of thiamine treatment on blood and tissue Pb levels during simultaneous or post-exposure to Pb in rat model. The spectroscopic studies revealed that Pb interacts with the pyrimidine ring of thiamine, leading to its solubilization at physiological pH. Further, thiamine reduced the Pb levels in blood, kidney and bone during both simultaneous and post-exposure Pb treatment. Interestingly, thiamine appears to prevent the accumulation of Pb in bone during simultaneous treatment. Together these results suggest that pyrimidine ring of thiamine mediates its interaction with Pb, leading to the prevention of its accumulation and/or increased clearance from tissues.

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Section: Resultsmentioning

confidence: 99%

Thiamine reduces tissue lead levels in rats: mechanism of interaction

2009

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“…Zinc plays an important role in various biological systems; it is critical for numerous cell processes and is a major regulatory ion in the metabolism of cells [3]. In the literature, diverse zinc complexes with biological activity are reported, but only zinc complexes with drugs used for the treatment of Alzheimer disease [4] and others showing antibacterial [5], anticonvulsant [6], antidiabetic [7], anti-inflammatory [8], antimicrobial [9] and antiproliferative-antitumor [10][11][12][13] activity are structurally characterized.…”

Section: Introductionmentioning

confidence: 99%

Zinc complexes of the antibacterial drug oxolinic acid: Structure and DNA-binding properties

Tarushi¹,

Psomas²,

Raptopoulou³

et al. 2009

Journal of Inorganic Biochemistry

136

104

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“…6 There is some evidence that heavy metals decrease bioavailability of thiamine, and that thiamine deficiency potentiates intestinal absorption of heavy metals. 7–10 …”

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confidence: 99%