Zinc(II) and Cadmium(II) Binary Complexes with Creatinine and Their Mixed-Ligand Complexes with L-Asparagine or L-Glutamic Acid: Potentiometrie Studies

Abstract

Creatinine is a physiological component of blood, brain and muscles and an important bioligand, which is the last product of the nitrogen metabolism in the vertebrates. In this study , the stability constants of binary complexes formed by creatinine with Zn(II) and Cd(II), and of the mixed-ligand complexes Zn(II)-creatinine-1-asparagine and Zn(II) creatinine-l-glutamic acid were determined by the Calvin-Bjerrum and Irving-Rossotti methods.The conditional formation constants and the formation pH ranges of complexes were determined.Relative abundance was plotted using conditional formation constants of the complexes and the steps of the complexes are shown in graphs. The composition of metal-creatinine complexes was determined as metal/ligand = 1: 1.

Preparation, spectroscopic, thermal and molecular docking studies of covid-19 protease on the manganese(II), iron(III), chromium(III) and cobalt(II) creatinine complexes

“…complexes showed conductance in the range of 22-29 ohm -1 cm 2 mol -1 at ambient temperature indicating non-electrolytic in nature [8], while the [Fe(C 4 H 7 N 3 O) 2 (Cl) 2 ]Cl.6H 2 O and [Cr(C 4 H 7 N 3 O) 2 (Cl) 2 ]Cl.6H 2 O complexes showed conductance in the range of 55-62 ohm -1 cm 2 mol -1 at ambient temperature indicating electrolytic in nature [13] and outside their coordination sphere there is one chloride counter ion present. The thermal nature of the complexes has been obtained by TGA, DrTGA/DTA analysis.…”

“…Five co-ordination modes have been established by X-ray crystallography: bidentate bridging through N(l)(ring) and deprotonated exocyclic NH site [9], bidentate binding via N(l) (ring) and the exocyclic O(C=O) [10]; monodentate binding through the N(l)(ring)site [11]; monodentate binding through the exocyclic O(C=O) [12]; and monodentate fashion through the deprotonated exocyclic NH group [10]. Creatinine is soluble in water and in aqueous solution it shows acidic properties (pK a = 4.89) [13]. The interaction of Pt(II) with creatinine is studied in different reaction conditions.…”

“…At L:M ratio from 4 to 10 several new complexes of Pt(II) are obtained, studied by spectroscopic methods and X-ray diffraction. In these monomeric species the ligand is coordinated only through the endogenic nitrogen [13]. Additionally, the tautomeric equilibrium of creatinine in aqueous solutions was studied and two tautomers (Figure 1) are found to coexist by comparing its experimental and calculated Raman spectra.…”

“…Additionally, the tautomeric equilibrium of creatinine in aqueous solutions was studied and two tautomers (Figure 1) are found to coexist by comparing its experimental and calculated Raman spectra. A water dimer being used to solvate creatinine would make the thermodynamic energy favourable to convert from the imino tautomer to the amino tautomer [12,13]. In this article, the Mn(II), Fe(III), Cr(III), and Co(II) creatinine complexes were isolated in solid state and their tentative structures were assigned on the basis of their elemental analyses, molar conductance, magnetic susceptibility measurements, thermal and spectral data.…”

ZIF-8 Nanoparticles Based Electrochemical Sensor for Non-Enzymatic Creatinine Detection

“…The attractive properties of ZIF-8 mentioned above facilitate it in the applications such as gas separation, sensing, and catalysis [15]. Moreover, the Zn 2+ ions in a ZIF-8 molecule can form a Zn-creatinine complex on the ZIF-8 based electrodes [16]. This property of ZIF-8 can be utilized for the quantitative determination of creatinine.…”