Zinc homeostasis during lactation in a population with a low zinc intake

Lei, Sian; Krebs, Nancy F.; Westcott, Jamie E; Feng-liang, LI; Li, Tong; Miller, Leland V.; Sonko, Bakary; Hambidge, Michael

doi:10.1093/ajcn/75.1.99

Cited by 54 publications

(25 citation statements)

References 21 publications

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“…Zinc has been demonstrated to have a wide variety of roles in mammalian system and may play a physiological role in mineralization of bone tissue (11). However, zinc nutritional deficiency is a global health problem (12,13). Hill et al in their study showed a relationship between zinc nutritive status and bone turnover in elder adults (14).…”

Section: Introductionmentioning

confidence: 99%

Copper, magnesium, zinc and calcium status in osteopenic and osteoporotic post-menopausal women

Mahdavi-Roshan

Ebrahimi

2015

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SummaryCopper, magnesium, zinc and calcium status were measured in postmenopausal women with osteoporosis (n = 23) and osteopenia (n = 28) as classified on the basis of the T-score of the femur neck and dual energy X-ray absorptiometry results. Anthropometric indices, dietary intake and serum copper, magnesium, zinc and calcium were assessed. The results of our study showed that the mean dietary intake of magnesium, zinc and calcium in post-menopausal women with low bone density were significantly lower than recommended dietary allowance. The mean serum levels of zinc (P = 0.001) and copper (P = 0.000) were significantly lower than normal range and 40.4% of this participants had serum magnesium levels lower than normal range. No statistically significant differences were observed between the osteopenic and osteoporotic groups with respect to serum levels and dietary intakes of copper, calcium, magnesium and zinc. Due to the mineral deficiency in post-menopausal women with low bone density and the key role of minerals on bone health, supplementation with magnesium, calcium, zinc and perhaps copper recommended.

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Section: Introductionmentioning

confidence: 99%

Copper, magnesium, zinc and calcium status in osteopenic and osteoporotic post-menopausal women

Mahdavi-Roshan

Ebrahimi

2015

ccmbm

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“…The positive impact of zinc supplementation on the growth of some stunted children, and on the prevalence of selected childhood diseases such as diarrhoea, suggests that zinc deficiency is likely to be a significant public health problem, especially in developing countries [15,16]. According to FAO's food balance data, it has been calculated that about 20 % of the world's population could be at risk of zinc deficiency [11].…”

Section: Resultsmentioning

confidence: 99%

Minerals Content, Essential Oils Composition and Physicochemical Properties of <i>Citrus jambhiri</i> Lush. (Rough Lemon) from the Sudan

Mohammed

Ibrahim

Omran

et al. 2013

ILCPA

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Minerals content of Citrus jambhiri (rough lemon) fruit was qualitatively and quantitatively analyzed using atomic absorption spectroscopy (AAS) and flame atomic emission spectrometry (FAES). The peel, moisture and ash contents of rough lemon were found to be 18.35 %, 23.75 % and 2.04 % respectively. Vitamin C (ascorbic acid) of rough lemon juice was found to be 70.0 mg/100 g. The chemical composition of essential oil of rough lemon peel was determined. The major compound was found to be limonene (84.5 %) followed by sabinene, β-myrcene, α-terpineol, 1,3-tetradecadiene and linalool.

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“…Fecal zinc consists of unabsorbed dietary zinc and the excretion of endogenous zinc. Thus adjustment in fecal endogenous zinc excretion has been suggested as the primary means of maintaining zinc homeostasis, since a short-term dietary zinc restriction can increase the absorption of intestinal zinc and decrease fecal endogenous zinc loss [51,52]. The sources of intestinal endogenous zinc are mainly derived from pancreas and biliary zinc secretion.…”

Section: Discussionmentioning

confidence: 99%

Effect of Hypothyroidism on Intestinal Zinc Absorption and Renal Zinc Disposal in Five-Sixths Nephrectomized Rats

Chen

Kuo

et al. 2005

JJP

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Both hypothyroid (Hypo) and hypozincemia are commonly observed in patients and animals with chronic renal failure (CRF). In CRF whether the hypothyroid plays a role in the pathogenesis of hypozincemia is unclear. This study is designed to investigate the effects of hypothyroid on intestinal zinc absorption and urinary zinc excretion in 5/6 nephrectomized (Nx) rats, because plasma zinc balance is attained through a controlled rate of intestinal uptake as well as renal reabsorption. Intestinal zinc absorption was carried out in jejunum and ileum segments by an in vivo perfusion technique and the renal zinc disposal was evaluated by a conventional method using a standard formula to calculate the zinc tubular reabsorption and the excretion of urinary zinc in 5/6 Nx rats with hypothyroidism. The Hypo-NxT rats showed a significant decrease in the rate of intestinal zinc absorption and in the response of plasma zinc levels during intestinal Zinc is an essential nutrient in humans and animals because it is a critical component of numerous metalloenzymes and zinc-dependent transcription factors [1]. Thus it is involved in many biological activities, such as fuel metabolism [2], protein synthesis [3], hormone metabolism [4,5], and cell division and differentiation [6][7][8]. Zinc is also implicated as a neuromodulator of certain postsynaptic neurons in the brain [9]. Because of these important functions, nutritional zinc deficiency can have devastating consequences to human and animal health, including growth retarda- zinc perfusion compared with Eu-NxT rats. They also had significantly lower levels of mucosal zinc and MT as well as lower content of liver zinc than Eu-NxT rats after intestinal zinc perfusion for 80 min. Hypo-NxT rats showed low plasma zinc levels, but had a similar output of pancreaticobiliary zinc and excretion of 24-h urine zinc compared with the Eu-NxT rats. When 2% alcohol intestinal perfusion was used to produce water diuresis, the Hypo-NxT rats presented a higher excretion of urinary zinc than the Eu-NxT rats did, especially during 2% alcohol intestinal zinc perfusion. In the Hypo-NxT rats, the lower plasma zinc levels may thus result from the hypothyroid because it reduces intestinal zinc absorption. Increasing the urine flow rate may aggravate the reduction of plasma zinc level in Hypo-NxT rats because of the increased excretion of urinary zinc. [The Japanese Journal of Physiology 55: [211][212][213][214][215][216][217][218][219] 2005]

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Zinc homeostasis during lactation in a population with a low zinc intake

Abstract: Zinc balance, including zinc secreted in breast milk, was maintained at approximately 2 mo of lactation in women whose habitual diet was low in zinc. Homeostasis was achieved by high fractional absorption of zinc and intestinal conservation of endogenous fecal zinc.

Cited by 54 publications

References 21 publications

Copper, magnesium, zinc and calcium status in osteopenic and osteoporotic post-menopausal women

Copper, magnesium, zinc and calcium status in osteopenic and osteoporotic post-menopausal women

Minerals Content, Essential Oils Composition and Physicochemical Properties of <i>Citrus jambhiri</i> Lush. (Rough Lemon) from the Sudan

Effect of Hypothyroidism on Intestinal Zinc Absorption and Renal Zinc Disposal in Five-Sixths Nephrectomized Rats

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