Zinc finger protein <i>Zac1</i> is expressed in chondrogenic sites of the mouse

Tsuda, Takeshi; Markova, Dessislava; Wang, Hui; Evangelisti, L; Pan, Te‐Cheng; Chu, Mon‐Li

doi:10.1002/dvdy.10439

Cited by 22 publications

(24 citation statements)

References 26 publications

(26 reference statements)

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“…In situ hybridization of mouse embryos showed that Zac1 transcript is predominantly localized in developing chondrogenic tissue (Tsuda et al, 2004). Zac1 is also expressed transiently in the myocardium, skeletal muscle, and basal aspect of the stratified embryonic epithelia.…”

Section: Gene Expression During Developmentmentioning

confidence: 99%

“…Zac1 is also expressed transiently in the myocardium, skeletal muscle, and basal aspect of the stratified embryonic epithelia. During cartilage development, the pattern of Zac1 expression is closely associated with the distribution of type II collagen mRNA in mesenchymal condensation and prehypertrophic chondrocytes (Tsuda et al, 2004). In mouse ATDC5 cells undergoing in vitro chondrogenesis, the Zac1 mRNA was upregulated in parallel with genes expressed in pre-cartilage but the Zac1 expression was low when type II collagen mRNA was markedly increased in differentiated cells.…”

Section: Gene Expression During Developmentmentioning

confidence: 99%

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LOT1 (ZAC1/PLAGL1) and its family members: Mechanisms and functions

Abdollahi

2006

Journal Cellular Physiology

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Lost-on-transformation 1 (LOT1) (PLAGL1/ZAC1) is a member of the novel subfamily of zinc-finger transcription factors, designated as PLAG family. The other members in this group include PLAG1 and PLAGL2, which share high homology with each other and with LOT1, particularly in their zinc-finger amino-terminal region. They are structurally similar but functionally different. For example, the LOT1 gene encodes a growth suppressor protein and is localized on human chromosome 6q24-25, a chromosomal region that is frequently deleted in many types of human cancers. The gene is maternally imprinted and is linked to developmental disorders such as growth retardation and transient neonatal diabetes mellitus (TNDM). LOT1 is a target of growth factor signaling pathway(s) and silenced by epigenetic mechanisms, as well as by the loss of heterozygosity in different tumor tissues. PLAG1 is a protooncogene that is localized on chromosome 8q12 and was found to be a target of several types of chromosomal rearrangement including the one identified in pleomorphic adenomas of the salivary gland. Since the discovery of the PLAG family members in 1997, much has been learned about their structure and function, as are summarized in this review. While the available data suggest that these proteins may play important roles in regulating normal physiological functions in the mammals, a great deal more about their signaling pathway(s), potential role in the complex pathologies such as cancer and developmental disorders, and functional relationship between different family members and splice variants still remains to be uncovered.

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Section: Gene Expression During Developmentmentioning

confidence: 99%

Section: Gene Expression During Developmentmentioning

confidence: 99%

LOT1 (ZAC1/PLAGL1) and its family members: Mechanisms and functions

Abdollahi

2006

Journal Cellular Physiology

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“…4B). The Zac1 transcript is predominantly localized in developing chondrogenic tissue and suggested that Zac1 is a potential regulatory gene involved in chondrogenic differentiation and cartilage development (39,40). Overexpression of a Hoxc8 transgenic mice has been reported to cartilage defects (14).…”

Section: Ncammentioning

confidence: 99%

Identification of aHoxc8-regulated transcriptional network in mouse embryo fibroblast cells

Lei

Juan

Kim

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

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The transcription factor, Hoxc8, is a member of the homeobox gene family that is vital for growth and differentiation. Previously, we identified 34 genes whose expression levels were changed at least 2-fold by forced expression of Hoxc8 in C57BL͞6J mouse embryo fibroblast cells using a mouse 16,463-gene oligonucleotide microarray. In the present study, we used the combined power of microarray profiling, global Hoxc8 DNA-binding site analysis, and high-throughput chromatin immunoprecipitation assays to identify direct and biologically relevant targets of Hoxc8 in vivo. Here we show that 19 of the 34 responsive genes contain Hoxc8 consensus DNA-binding sequence(s) in their regulatory regions. Chromatin immunoprecipitation analysis indicated that Hoxc8-DNA interaction was detected in five of the 19 candidate genes. All of these five target genes have been implicated in oncogenesis, cell adhesion, proliferation, and apoptosis. Overall, the genes described here should aid in the understanding of global regulatory networks of Hox genes and to provide valuable insight into the molecular basis of Hoxc8 in development and carcinogenesis.cancer ͉ chromatin immunoprecipitation ͉ Hox protein binding sites ͉ microarray

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“…Nevertheless, their biological role in neural development and in mature brain remains uncertain. Furthermore, Zac1 and hZAC are highly expressed in somites and limbs during early embryonic stages (Piras et al, 2000;Valente and Auladell, 2001;Tsuda et al, 2004), as well as in cartilage primordium sites (Valente and Auladell, 2001;Tsuda et al, 2004) and skeletal muscle Ma et al, 2004). In adult tissues, hZAC (human homolog of Zac1 mouse gene) and Zac1 are expressed to a low extent in skeletal muscle and bone marrow (Varrault et al, 1998;Piras et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Zac1 is expressed in progenitor/stem cells of the neuroectoderm and mesoderm during embryogenesis: Differential phenotype of the Zac1‐expressing cells during development

Valente

Junyent

Auladell

2005

Developmental Dynamics

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Zac1, a new zinc-finger protein that regulates both apoptosis and cell cycle arrest, is abundantly expressed in many neuroepithelia during early brain development. In the present work, we study the expression of Zac1 during early embryogenesis and we determine the cellular phenotype of the Zac1-expressing cells throughout development. Our results show that Zac1 is expressed in the progenitor/stem cells of several tissues (nervous system, skeleton, and skeletal muscle), because they colocalize with several progenitor/stem markers (Nestin, glial fibrillary acidic protein, FORSE-1, proliferating cell nuclear antigen, and bromodeoxyuridine). In postnatal development, Zac1 is expressed in all phases of the life cycle of the chondrocytes (from proliferation to apoptosis), in some limbic ␥-aminobutyric acid-ergic neuronal subpopulations, and during developmental myofibers. Therefore, the intense expression of Zac1 in the progenitor/stem cells of different cellular lineages during the proliferative cycle, before differentiation into postmitotic cells, suggests that Zac1 plays an important role in the control of cell fate during neurogenesis, chondrogenesis, and myogenesis. Developmental Dynamics 233:667-679, 2005.

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Zinc finger protein Zac1 is expressed in chondrogenic sites of the mouse

Cited by 22 publications

References 26 publications

LOT1 (ZAC1/PLAGL1) and its family members: Mechanisms and functions

LOT1 (ZAC1/PLAGL1) and its family members: Mechanisms and functions

Identification of aHoxc8-regulated transcriptional network in mouse embryo fibroblast cells

Zac1 is expressed in progenitor/stem cells of the neuroectoderm and mesoderm during embryogenesis: Differential phenotype of the Zac1‐expressing cells during development

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