Zinc finger protein 593 is upregulated during skeletal muscle atrophy and modulates muscle cell differentiation

Lynch, Sarah A.; McLeod, Marc; Orsech, Hannah C.; Cirelli, Alexander M.; Waddell, David

doi:10.1016/j.yexcr.2019.111563

Cited by 10 publications

(4 citation statements)

References 29 publications

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“…The point measurement for this sample in point 3 was highly interesting, because for two elements (iron and zinc) an increased concentration was noticed in the same place. This is likely due to local aggregation of myoglobin, resulting from subcellular damage to the muscle, which is coupled to another zinc compoundforming protein [6].…”

Section: Resultsmentioning

confidence: 99%

Sub-cellular elemental imaging of human muscle tissues affected by neuromuscular diseases

et al. 2021

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Various types of neuromuscular diseases differ in symptoms, pathology, and clinical picture but one of their common elements is muscle weakness, which could lead to human motor activities impairment and in many cases to shortening of life span and even death due to respiratory failure. That is why it is very important to better understand the underlying causes of these diseases to be able to implement new methods of treatment more effectively. This paper presents the results of the elemental analysis of human muscular tissues affected by dystrophy and myopathy. For this purpose, the particle-induced X-ray emission method was used, which is perfectly suited for measuring light elements. The samples were analysed for differences in the elemental composition of Na, Mg, P, S, Cl, K, Fe, Zn, and Br. The results were presented in the form of elemental concentration maps and a thorough statistical analysis of the obtained data using the advanced statistical methods.

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Section: Resultsmentioning

confidence: 99%

Sub-cellular elemental imaging of human muscle tissues affected by neuromuscular diseases

et al. 2021

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“…N-myc downregulated gene family ( NDRG4 ) regulates smooth muscle cells ( Qu et al, 2016 ). Similar to NDRG4 , ZNF593 regulates muscle cell differentiation ( Lynch et al, 2019 ). Consistently, NDRG4 and ZNG593 are less expressed in the proximal cecum because the primary function of the cecum is thought to be related to modulate immunity and metabolism through the microbiota; whereas the jejunum and ileum are primarily responsible for digestion and absorption of nutrients that require contraction of smooth muscles during peristalsis.…”

Section: Discussionmentioning

confidence: 99%

Transcriptomes of an Array of Chicken Ovary, Intestinal, and Immune Cells and Tissues

Overbey

Catini

et al. 2021

Front. Genet.

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While the chicken (Gallus gallus) is the most consumed agricultural animal worldwide, the chicken transcriptome remains understudied. We have characterized the transcriptome of 10 cell and tissue types from the chicken using RNA-seq, spanning intestinal tissues (ileum, jejunum, proximal cecum), immune cells (B cells, bursa, macrophages, monocytes, spleen T cells, thymus), and reproductive tissue (ovary). We detected 17,872 genes and 24,812 transcripts across all cell and tissue types, representing 73% and 63% of the current gene annotation, respectively. Further quantification of RNA transcript biotypes revealed protein-coding and lncRNAs specific to an individual cell/tissue type. Each cell/tissue type also has an average of around 1.2 isoforms per gene, however, they all have at least one gene with at least 11 isoforms. Differential expression analysis revealed a large number of differentially expressed genes between tissues of the same category (immune and intestinal). Many of these differentially expressed genes in immune cells were involved in cellular processes relating to differentiation and cell metabolism as well as basic functions of immune cells such as cell adhesion and signal transduction. The differential expressed genes of the different segments of the chicken intestine (jejunum, ileum, proximal cecum) correlated to the metabolic processes in nutrient digestion and absorption. These data should provide a valuable resource in understanding the chicken genome.

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“…SEAP reporter assays were performed as previously described (60)(61)(62). All reporter assays were conducted in C2C12 cells cultured in 12-well plates at a seeding density of 100,000 cells/well.…”

Section: Secreted Alkaline Phosphatase (Seap) Reporter Gene Assaysmentioning

confidence: 99%

Identification and Characterization of Fbxl22, a novel skeletal muscle atrophy-promoting E3 ubiquitin ligase

Hughes

Baehr

Driscoll

et al. 2020

Preprint

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Muscle-specific E3 ubiquitin ligases have been identified in muscle atrophy-inducing conditions. The purpose of the current study was to explore the functional role of Fbxl22, and a newly identified splice variant , in skeletal muscle homeostasis and neurogenic muscle atrophy. The full-length gene and novel splice variant are transcriptionally induced early (after 3 days) during neurogenic muscle atrophy. In vivo overexpression of Fbxl22 isoforms in mouse skeletal muscle lead to evidence of myopathy/atrophy suggesting that both are involved in the process of neurogenic muscle atrophy. Knockdown of Fbxl22 in MuRF1 KO muscles resulted in significant additive muscle sparing at 7 days of denervation. Targeting two E3 ubiquitin ligases appears to have a strong additive effect on protecting muscle mass loss with denervation and these findings have important implications in the development of therapeutic strategies to treat muscle atrophy.

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Zinc finger protein 593 is upregulated during skeletal muscle atrophy and modulates muscle cell differentiation

Cited by 10 publications

References 29 publications

Sub-cellular elemental imaging of human muscle tissues affected by neuromuscular diseases

Sub-cellular elemental imaging of human muscle tissues affected by neuromuscular diseases

Transcriptomes of an Array of Chicken Ovary, Intestinal, and Immune Cells and Tissues

Identification and Characterization of Fbxl22, a novel skeletal muscle atrophy-promoting E3 ubiquitin ligase

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