Zinc electrodeposition on copper substrate using cyanide bath for the production of 66,67,68Ga

Kakavand, T.; Sadeghi, Mahdi; Mokhtari, L.; Majdabadi, Abbas

doi:10.1007/s10967-009-0341-y

Cited by 12 publications

(2 citation statements)

References 4 publications

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“…Electroplated zinc targets resistant to irradiation currents up to 50 μA are present in the literature (e.g., (Neirinckx, 1976). However, specific activities and enriched isotope recovery efficiencies are unreported by these studies, or commonly, copper plating substrates necessitate additional separation prior to replating (Kakavand et al ., 2010; Naik et al ., 2002; Rowshanfarzad et al ., 2004; Sattari et al ., 2006). After irradiation of zinc targets, electrodeposition from their radioactive, dissolved solutions has also been used to speed separation, post-irradiation but again, the reactivity and elemental composition of the final product in solution are unreported (Neirinckx, 1976).…”

Section: Introductionmentioning

confidence: 99%

Very high specific activity 66/68Ga from zinc targets for PET

Engle

López‐Rodríguez

Gaspar-Carcamo

et al. 2012

Applied Radiation and Isotopes

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This work describes the production of very high specific activity 66/68Ga from natZn(p,n) and 66Zn(p,n) using proton irradiations between 7 and 16 MeV, with emphasis on 66Ga for use with common bifunctional chelates. Principle radiometallic impurities are 65Zn from (p,x) and 67Ga from (p,n). Separation of radiogallium from target material is accomplished with cation exchange chromatography in hydrochloric acid solution. Efficient recycling of Zn target material is possible using electrodeposition of Zn from its chloride form, but these measures are not necessary to achieve high specific activity or near-quantitiative radiolabeling yields from natural targets. Inductively coupled plasma mass spectroscopy (ICP-MS) measures less than 2 ppb non-radioactive gallium in the final product, and the reactivity of 66Ga with common bifunctional chelates, decay corrected to the end of irradiation, is 740 GBq/μmol (20 Ci/μmol) using natural zinc as a target material. Recycling enriched 66Zn targets increased the reactivity of 66Ga with common bifunctional chelates.

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Section: Introductionmentioning

confidence: 99%

Very high specific activity 66/68Ga from zinc targets for PET

Engle

López‐Rodríguez

Gaspar-Carcamo

et al. 2012

Applied Radiation and Isotopes

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show abstract

“…Excitation functions for the production of gallium-68 from the [Zn 68 (p,n)Ga 68 ], [Zn 68 (d,2n)Ga 68 ], [Zn 70 (p,3n)Ga 68 ] and [Cu 65 (a,n)Ga 68 ] nuclear reactions have been calculated 38 using ALICE-91 and TALYS-1.0 computer codes. Such calculations are very necessary since many gallium radioisotopes result 39 from the irradiation of zinc metal. Chromatographic methods have been described 40,41 for the extraction of the gallium-68 that results from the proton irradiation of zinc-68.…”

Section: Elements Of Modest Massmentioning

confidence: 99%