Zinc deficiency in patients with idiopathic taste impairment with regard to angiotensin converting enzyme activity

Takeda, Noriaki; Takaoka, T; Ueda, Chizuru; Toda, Naoki; Kalubi, Bukasa; Yamamoto, Shigeru

doi:10.1016/j.anl.2004.09.006

Cited by 16 publications

(15 citation statements)

References 17 publications

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“…We also reported the relevance of taste impairment and the low nutritional state of zinc (Takeda et al, 2004). In addition, some reports indicate that taste impairment in elderly people is a problem (Yamamoto, 1996).…”

Section: Introductionmentioning

confidence: 75%

“…Although there are few reports (Hyun et al, 2004) on the effect of zinc intake in elderly people, our results suggest that the supply of zinc through meals in elderly people has a beneficial effect. In order to contribute towards a healthy life, it is important to assay serum zinc levels for early screening and to improve zinc nutritional status by diet or temporary supplementation in elderly people (Takeda et al, 2004;Andriollo-Sanchez et al, 2005;Kurasawa and Kubori, 2006).…”

Section: Discussionmentioning

confidence: 99%

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Ratio of low serum zinc levels in elderly Japanese people living in the central part of Japan

et al. 2006

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Objective: Elderly patients often have impaired taste, nausea, anorexia and delayed healing of decubitus. In many of these patients, serum zinc levels are low and they respond to zinc supplementation. To date, no epidemics of zinc deficiency have been reported in Japan. We studied the prevalence of zinc deficiency and its causative factors in a typical local town in Japan. Design: Cross-sectional study. Setting: Nagano Prefecture (central Japan). Subjects and methods: Serum zinc levels were measured in 1009 habitants (18-96 years old) who participated in an annual mass health examination program of the City in 2003. Of all subjects, 86 with low serum zinc (o65 mg/dl) or high zinc (X90 mg/ dl) levels were randomly selected, and a dietary survey using 24-h recalling methods for 2 consecutive days was performed in 2004. Among them, blood was collected in the morning from 50 subjects (26-94 years old). Results: The percentage of those with low serum zinc levels (2.5th percentile of Americans) was 37.9% in the elderly (X60 years old). The age-adjusted prevalence of low serum zinc was 21.1% in the aged population. A positive correlation was detected between zinc intake and serum zinc levels in elderly subjects (X60 years old). Conclusions: The possibility of zinc deficiency in adult inhabitants in central Japan rises with age. The deficiency correlates with dietary zinc intake. Sponsorship: This research was supported by a grant from local government officials in Tomi City (2004) and the funding of Fancl Corporation.

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Section: Introductionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Ratio of low serum zinc levels in elderly Japanese people living in the central part of Japan

et al. 2006

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“…DNA methylation is mediated by the DNA methyltransferase (DNMT) enzyme family, which includes DNMT1, 3a and 3b. DNMT1 is responsible for the maintenance of DNA methylation patterns and has a preference for hemi-methylated DNA, (64) , Takeda et al (65) whereas DNMT3a and 3b are associated with the de novo methylation of previously unmethylated CpG sites (35,36) . These DNMT are essential for normal embryonic development (37,38) .…”

Section: Epigenetic Regulation Of Gene Expressionmentioning

confidence: 99%

Does promoter methylation of the SLC30A5 (ZnT5) zinc transporter gene contribute to the ageing-related decline in zinc status?

2009

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A decline in Zn status with ageing may contribute to the development of frailty, including impaired immune function, and increased incidence of age-related degenerative diseases. This decline may be a result of reduced dietary Zn intake and/or impaired Zn absorption in the gut. The Zn transporter ZnT5 may play a key role in the absorption of dietary Zn. The corresponding gene (SLC30A5) has a CpG island in its promoter region, so could be regulated by epigenetic mechanisms. It is hypothesised that methylation of the SLC30A5 promoter region is increased with age and that a resulting reduction in ZnT5 expression contributes to the decline in Zn status observed with ageing. This hypothesis has been addressed through (1) studies of effects of SLC30A5 promoter methylation on gene expression in vitro and (2) in vivo measurements of the DNA methylation status of this gene domain. It has been established in vitro that methylation of the human SLC30A5 promoter region results in reduced expression of an associated reporter gene. Second, this gene region shows variable levels of methylation in vivo. Correlation between the level of methylation at this locus and age would support the hypothesis that age-related hypermethylation of this region has the potential to modulate dietary Zn absorption. This premise is being investigated by analysis of additional samples from a human adult cohort to test the hypothesis that methylation of the SLC30A5 promoter region contributes to the age-related decline in Zn status.

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“…It is present in saliva (Watanabe et al, 2005) as well as in the salivary gland (Tanaka, 2002) and appears to be linked to gustatory nerve activity (Yokoi et al, 2003). Taste impairment as a result of drug therapy or disease has been observed in cases of zinc deficiency (Kettaneh et al, 2002;Tomita & Yoshikawa, 2002), while supplemental zinc has been shown to ameliorate taste disorder in certain zinc-depleted patient groups (Stoll & Oepen, 1994;Takeda et al, 2004;Heckmann et al, 2005). We do not yet fully understand the nature or magnitude of agerelated taste sensitivity decline.…”

Section: Introductionmentioning

confidence: 99%

Zinc status and taste acuity in older Europeans: the ZENITH study

Stewart-Knox

Simpson²,

Parr

et al. 2005

Eur J Clin Nutr

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Background: Age-related decline in taste acuity may be both a cause and an effect of depleted zinc and/or increased zinc requirement. Objective: The aim of this study was to explore associations between zinc status and taste acuity in healthy older European adults aged 55-90 y. Sample: Volunteers were recruited within Italy (n ¼ 108 aged 70-90 y), the United Kingdom (UK) (n ¼ 93 aged 55-70) and two regions of France (n ¼ 186), Grenoble (aged 70-90 y) and Clermont-Ferrand (aged 55-70 y). Methods: A signal detection theory approach was adopted, employing a three-alternative, forced-choice procedure. The data were converted to R-indices and bivariate correlations were computed to explore relationships between serum zinc, erythrocyte zinc and taste acuity. ANOVA was undertaken to determine regional differences in zinc status. Results: Higher erythrocyte zinc status was associated with better acuity for salt (sodium chloride) taste in the sample as a whole (P ¼ 0.012) (n ¼ 385). Higher serum zinc levels were associated with greater sensitivity to sour taste (citric acid) (P ¼ 0.015) only in the older groups (aged 70-90 y). There were no apparent associations between serum or erythrocyte zinc status and acuity for bitter (quinine) or sweet (sucrose) tastes irrespective of age. Conclusion: These results agree with those previously suggesting that age-related detriment in sensitivity for salt taste may be associated with depleted zinc.

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Zinc deficiency in patients with idiopathic taste impairment with regard to angiotensin converting enzyme activity

Cited by 16 publications

References 17 publications

Ratio of low serum zinc levels in elderly Japanese people living in the central part of Japan

Ratio of low serum zinc levels in elderly Japanese people living in the central part of Japan

Does promoter methylation of the SLC30A5 (ZnT5) zinc transporter gene contribute to the ageing-related decline in zinc status?

Zinc status and taste acuity in older Europeans: the ZENITH study

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