Zinc deficiency impairs ischemia-induced angiogenesis

Tsuruoka, Takuya; Kodama, Akio; Yamaguchi, Satoshi; Masutomi, Tomohiro; Kôyama, Akio; Murohara, Toyoaki; Komori, Kimihiro; Shibata, Rei

doi:10.1016/j.jvssci.2021.09.023

Cited by 7 publications

(4 citation statements)

References 27 publications

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“…What is more, the skin perfusion pressures were positively associated with the serum zinc levels in patients with chronic limb-threatening ischemia. The authors concluded that circulating Zn levels could be a useful marker for the assessment of atherosclerosisbased vascular disease such as limb ischemia [6].…”

Section: Introductionmentioning

confidence: 99%

Serum zinc values, ankle brachial index and mortality in hemodialysis patients

et al. 2022

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Introduction The atherosclerotic state of haemodialysis (HD) patients may be influenced by heavy metals. The purpose of our study was to assess the relationship between serum zinc (Zn) ankle brachial index (ABI) as a non-invasive diagnostic tool for atherosclerosis, and mortality in chronic haemodialysis (HD) patients. Methods Sixty one HD patients were included (mean age 61.2 ± 13.8 years). The ABI was measured with an automated measuring device (ABPI MD, MESI®, Slovenia). Two groups of patients were formed based on the median value of Zn (14.1 mcmol/l). The average observation time was 2.8 years. Comorbidities (arterial hypertension (AH), diabetes mellitus (DM), dyslipidaemia), smoking and oral nutritional supplements (ONS) consumption were noted. Survival rates were analysed by Kaplan–Meier and Cox regression was used to determine the influence of Zn, ABI, AH, DM, dyslipidaemia, smoking and ONS. Results Zn values were between 9.2 and 23.5 mcmol/l (14.4 ± 2.34), ABI values ranged from 0.8 to 1.4 (1.14 ± 0.12). Patients with lower Zn values had lower ABI (p = 0.036). Mean survival time of patients with higher Zn values was 985 days ± 277 days and with lower Zn values 1055 ± 143 days. Six (19.4%) patients with lower Zn and five (16.7%) patients with higher Zn died. We found statistically insignificant lower survival in patients with higher Zn. We failed to find any predictor of all-cause mortality, except for ONS consumption (95% CI 1.6–33.3; p = 0.012). Conclusions Lower Zn is associated with lower ABI in HD patients, but we found no impact of Zn on patient survival.

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Section: Introductionmentioning

confidence: 99%

Serum zinc values, ankle brachial index and mortality in hemodialysis patients

et al. 2022

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“…Zinc deficiency can result in the impairment of organ development, as well as the vascular system [ 181 ]. Mice with surgically induced hind limb ischemia subjected to a zinc-deficient diet displayed restricted revascularization [ 182 ]. In comparison to the control, the zinc deficient mice displayed decreased perfusion rates and VEGF-A levels in addition to having increased ROS levels.…”

Section: Discussionmentioning

confidence: 99%

“…To examine a possible correlation, the skin prefusion pressure (SPP) was measured and used as an index for tissue blood prefusion. Indeed, a multiple linear regression analysis indicated a positive correlation between serum zinc levels and SPP [ 182 ].…”

Section: Discussionmentioning

confidence: 99%

Transition metals in angiogenesis – A narrative review

Durig

Calcagni

Buschmann

2023

Materials Today Bio

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“…As shown in Figure 3A,B, the rates of wound healing and freedom from MALE were significantly better in group SD than in group NSD (P<0.001 and P<0.001, respectively). Zn supplementation was associated with better wound healing (HR, 3.93; 95% CI, 1.68-9.23: P=0.002) and freedom from MALE (HR, 21 It is well accepted that oxidative damage is a major cause of tissue injury and that redox regulation plays a prominent role in wound repair. Thus, Zn plays a significant role in regulating every phase of the wound healing process, affecting aspects ranging from membrane repair and oxidative stress to coagulation, inflammation, immunity, and remodeling.…”

Section: Clinical Outcomes After Zn Supplementation In Patientsmentioning

confidence: 99%

Impact of Serum Zinc Level and Oral Zinc Supplementation on Clinical Outcomes in Patients Undergoing Infrainguinal Bypass for Chronic Limb-Threatening Ischemia

Kodama

Komori

Kôyama

et al. 2022

Circ J

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tality risk after revascularization in patients with CLTI. 5,6 Several guidelines recommend that an interdisciplinary care team, including nutritionists/dietitians, evaluate and provide comprehensive care for patients with CLTI; 1,7 however, the efficacy of nutritional interventions in patients with complicated CLTI is not well understood.Zinc (Zn), one of the essential micronutrients for humans, is involved in numerous biological functions and is considered a multipurpose trace element due to its capacity to bind to more than 300 enzymes and more than 2,000 transcription factors. 8 It has also been reported to play an important role in wound healing. 9 In addition, several reports have recently reinforced the association between Zn deficiency and cardiovascular disease, especially ath-C hronic limb-threatening ischemia (CLTI) is the most severe form of peripheral artery disease (PAD) and is characterized by ischemic resting pain and tissue loss. Revascularization is needed to relieve ischemic pain, heal ischemic wounds, prevent limb loss, and preserve ambulation and quality of life. Although the application of endovascular therapy (EVT) for CLTI has recently increased, surgical bypass using an autogenous vein plays an important role in the treatment of CLTI. 1 Several studies have recommended surgical bypass for appropriately selected patients because of its durable revascularization and superior wound healing rate compared to EVT. [2][3][4] Recently, several studies have reported that preoperative nutritional status is independently associated with the mor-

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Zinc deficiency impairs ischemia-induced angiogenesis

Cited by 7 publications

References 27 publications

Serum zinc values, ankle brachial index and mortality in hemodialysis patients

Serum zinc values, ankle brachial index and mortality in hemodialysis patients

Transition metals in angiogenesis – A narrative review

Impact of Serum Zinc Level and Oral Zinc Supplementation on Clinical Outcomes in Patients Undergoing Infrainguinal Bypass for Chronic Limb-Threatening Ischemia

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