Zinc deficiency correlates to spontaneous bacterial peritonitis in patients with cirrhotic ascites

Hanna, Michel A.; Fouad, Mohamed Hassan Ahmed; ElGhandour, Ahmed Mohamed; Ali, Heba H.

doi:10.4103/ejim.ejim_49_18

Cited by 2 publications

(4 citation statements)

References 12 publications

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“…This is consistent with research by Mohammad et al (20) , who found no statistically significant variations in Hb, ALT, albumin, bilirubin, INR, or creatinine levels between individuals with and without SBP. Our results were different from those of Hanna and colleagues (21) , who claimed that patients without SBP had blood albumin levels that were statistically considerably higher. Additionally, the SBP group's AST and serum creatinine were statistically significantly greater than those of the other group.…”

Section: Discussioncontrasting

confidence: 99%

“…According to our research, the ascitic fluid polymorphonuclear count was significantly higher in the SBP group when compared to non-SBP group (P<0.001). These findings were consistent with Hanna et al (21) finding that SBP patients had a higher ascitic PMN count than non-SBP patients. They also reported similar findings.…”

Section: Discussionsupporting

confidence: 92%

“…Concerning serum zinc level, our study showed that serum zinc was significantly lower in group B (SBP group) compared to group A (non-SBP group) (63.1 ±11.64 vs. 84.79 ±19.12 µg/dl; P< 0.001), and at a cutoff level ≤70 µg/dL, it had a sensitivity of 84%, 64% specificity, 70% PPV and 80% NPV for predicting SBP with an area under the curve (AUC) = 0.860). These findings were corroborated by Hanna et al (21) study, which found that patients with SBP had lower serum zinc levels than those with no complicated ascites (49.11±11.8 vs. 79.27±9.58 g/dl; P<0.001) and that SBP could be accurately predicted in cirrhotic ascitic diseased people at a cutoff level below 70.5µ g/dl with a sensitivity of 94. This was inconsistent with the results of Soomro et al (23) , who showed that zinc levels were statistically significantly lower in individuals with liver cirrhosis associated with SBP.…”

Section: Discussionsupporting

confidence: 61%

“…According to our research, blood zinc levels and PMN levels in ascitic fluid correlated negatively (r = -0.341). Hanna et al (21) , who discovered a correlation between a zinc shortage and an increase in ascitic fluid PMNs, reported similar findings. Sengupta and colleagues (10) came to the conclusion that ascites and SBP were negatively linked with serum zinc concentrations.…”

Section: Discussionmentioning

confidence: 64%

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Low Serum Zinc and Spontaneous Bacterial Peritonitis in Patients with HCV-Related Liver Cirrhosis

Afifi¹,

Foda²,

Elhalim³

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: A serious and common consequence in cirrhotic liver patient is spontaneous bacterial peritonitis (SBP), it means infection of ascitic fluid with unknown operationally treatable etiology in the abdomen. The body contains one of the most prevalent trace elements, zinc (Zn), which is important for growth and development. Objective: To investigate the relationship between low serum Zn levels and SBP development in HCV-related cirrhotic liver patients. Patients and Methods:The study was done on fifty patients with HCV related cirrhotic liver suffering from ascites. Half of them without SBP, classified as group (A), and the other half with SBP on the basis of ascitic fluid polymorphonuclear (PMN) leukocytic count of ≥250 cells/μL in the absence of subsequent peritonitis, no matter the culture results of the ascitic fluid, classified as group (B). Results: The levels of C-reactive protein (CRP), platelet count, and white blood cells (WBCs) were significantly different between the two research groups (P<0.001, =0.016, =0.03 respectively). Ascitic fluid PMN count increased significantly in SBP group, which means statistically significant difference between the 2 groups (P<0.001). Serum zinc levels was significantly lower in group B than group A [63.1 µg/dL (46-95) vs 84.79 µg/dL (65-130); P<0.001]. With 0.860 as area under the curve (AUC), serum zinc was significant at a threshold level of ≤70 µg/dL with a sensitivity of 84 percent and 64 percent specificity for predicting SBP. Conclusion: Serum zinc levels in cirrhotic individuals with HCV who had been diagnosed with SBP were found to be considerably low.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 92%