Zinc deficiency and tinnitus

Ochi, Kentaro; Kinoshita, Hirotsugu; Kenmochi, Mutsumi; Nishino, Hirohito; Ohashi, Toru

doi:10.1016/s0385-8146(02)00145-1

Cited by 28 publications

(10 citation statements)

References 11 publications

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“…Zinc has been proposed as a treatment for tinnitus, particularly in patients with hypozincemia (304–307). While positive results have been reported in some patients (308), most well-controlled, double-blind, placebo-controlled studies have found little or no improvement in tinnitus with zinc therapy, except in a few patients with low zinc serum levels (290, 309, 310).…”

Section: Drug Therapy For Tinnitus: Pharmacological Studiesmentioning

confidence: 99%

Pharmacological treatments for tinnitus: New and old

Salvi¹,

Lobariñas²,

Sun³

2009

Drugs Fut

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Subjective tinnitus, the phantom ringing or buzzing sensation that occurs in the absence of sound, affects 12–14% of adults; in some cases the tinnitus is so severe or disabling that patients seek medical treatment. However, although the economic and emotional impact of tinnitus is large, there are currently no FDA-approved drugs to treat this condition. Clinical trials are now underway to evaluate the efficacy of N-methyl-d-aspartate (NMDA) and dopamine D2 antagonists, selective serotonin reuptake inhibitors (SSRIs), γ-aminobutyric acid (GABA) agonists and zinc dietary supplements. Previous off-label clinical studies, while not definitive, suggest that patients with severe depression may experience improvement in their tinnitus after treatment with antidepressants such as nortriptyline or sertraline. A small subpopulation of patients with what has been described as “typewriter tinnitus” have been shown to gain significant relief from the anticonvulsant carbamazepine. Preliminary studies with misoprostol, a synthetic prostaglandin E1 analogue, and sulpiride, a dopamine D2 antagonist, have shown promise. Animal behavioral studies suggest that GABA transaminase inhibitors and potassium channel modulators can suppress tinnitus. Additionally, improvements in tinnitus have also been noted in patients taking melatonin for significant sleep disturbances. Like other complex neurological disorders, one drug is unlikely to resolve tinnitus in all patients; therapies targeting specific subgroups are likely to yield the greatest success.

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Section: Drug Therapy For Tinnitus: Pharmacological Studiesmentioning

confidence: 99%

Pharmacological treatments for tinnitus: New and old

Salvi¹,

Lobariñas²,

Sun³

2009

Drugs Fut

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“…The limited literature on tinnitus cases with normal audiometry is restricted to the study of otoacoustic emissions [10][11][12][13][14] , ABR 15 , auditory processing [16][17][18] , high frequency audiometry 19 and zinc deficiency 20 . We did not find studies that approached clinical characteristics and repercussions of tinnitus in this minority group of patients or any study that compared them to a group of subjects with hearing loss.…”

Section: Introductionmentioning

confidence: 99%

Zumbido em pacientes com audiometria normal: caracterização clínica e repercussões

Sánchez

Medeiros

Levy

et al. 2005

Rev. Bras. Otorrinolaringol.

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Pat ients with tinnitus and normal hearing constitute an important group, given that findings do not suffer influence of the hearing loss. However, this group is rarely studied, so we do not know whether its clinical characteristics and interference in daily life are the same of those of the patients with tinnitus and hearing loss. Aim: To compare tinnitus characteristics and interference in daily life among patients with and without hearing loss. Study design: historic cohort. Material and Method: Among 744 tinnitus patients seen at a Tinnitus Clinic, 55 with normal audiometry were retrospectively evaluated. The control group consisted of 198 patients with tinnitus and hearing loss, following the same protocol. We analyzed the patients' data as well as the tinnitus characteristics and interference in daily life. Results: The mean age of the studied group (43.1 ± 13.4 years) was significantly lower than that of the control group (49.9 ± 14.5 years). In both groups, tinnitus was predominant in women, bilateral, single tone and constant, but there were no differences between both groups. The interference in concentration and emotional status (25.5% and 36.4%) was significantly lower in the studied group than that of the control group (46% and 61.6%), but it did not happen in regard to interference over sleep and social life. Conclusions: Patients with tinnitus and normal hearing showed similar characteristics when compared to those with hearing loss. However, the age of the patients and the interference over concentration and emotional status were significantly lower in this group.

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“…The reported prevalence of zinc deficiency in tinnitus varies between 2% and 69% [17][18][19][20][21]. Gersdorff et al [20] detected zinc deficiencies in 68.7% of 115 tinnitus patients; Paaske et al [21] reported deficiencies in only 1 of 48 patients.…”

Section: Discussionmentioning

confidence: 99%

“…Although there are studies reporting positive correlations between tinnitus and zinc deficiency [8,17,18,20,22], several other studies do not report any such correlation [19,21]. Gersdorff [20] reported that zinc supplementation in tinnitus patients was effective in 52% of cases.…”

Section: Discussionmentioning

confidence: 99%