Zinc deficiency and thymus ultrastructure in rats

Mercalli, M.E.; Seri, S; Aquilio, E.; Cramarossa, L; Gobbo, V. Del; Accinni, L.; Toniette, G.

doi:10.1016/s0271-5317(84)80040-8

Cited by 8 publications

(2 citation statements)

References 7 publications

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“…Leukopenia, a reduction in total white blood cells, is characteristic of early zinc deficiency and has been shown to contribute to compromised immunity. 36 , 37 In this study, mice fed the −Zn diet experienced decreased total white blood cell counts in peripheral blood ( Table 2 ). The percentage of lymphocytes was significantly increased in the zinc inadequate cohort, while the combination of control diet and LPS treatment decreased the percentage of lymphocytes in these animals.…”

Section: Resultsmentioning

confidence: 59%

Implications of compromised zinc status on bone loss associated with chronic inflammation in C57BL/6 mice

Chongwatpol

Rendina-Ruedy

Stoecker

et al. 2015

JIR

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Compromised zinc status and chronic inflammation are independent factors that can contribute to bone loss. However, zinc’s role in regulating lymphoid and myeloid cell populations, combined with the interplay between the immune and skeletal systems raises the question as to the extent to which a low-grade inflammatory challenge in the context of marginal zinc deficiency would exacerbate bone loss. To address this question, young adult C57BL/6 male mice (n=32) were used in a 2×2 factorial design with dietary zinc (adequate or 35 ppm vs inadequate or −Zn =5 ppm) and lipopolysaccharide (LPS, 0 or 0.1 mg/kg body weight). Mice were fed their respective diets for 10 weeks. On the 6th week, mice had a slow release pellet implanted to induce a low-grade inflammation for the final 4 weeks of the study. −Zn induced a decrease in total white cell counts and peripheral lymphocytes, whereas LPS increased blood monocytes. LPS significantly reduced spine bone mineral density and trabecular bone volume and number of the vertebral body compared with both zinc adequate and inadequate without LPS groups. Likewise, the most pronounced effects on bone strength occurred with LPS, however, −Zn also had negative effects on the bone von Mises stresses. LPS induced an increase in TNF-α and this response was further increased with −Zn. Although the marginal zinc deficiency altered immune function, bone loss was not exacerbated with low-grade chronic inflammation in marginally zinc-deficient young adult mice. These findings demonstrate that in young adult animals an immune challenge modestly increases the inflammatory response and worsens bone biomechanics in the context of a marginal zinc deficiency, but not to the extent that more severe adverse outcomes are observed on bone structural parameters.

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Section: Resultsmentioning

confidence: 59%

Implications of compromised zinc status on bone loss associated with chronic inflammation in C57BL/6 mice

Chongwatpol

Rendina-Ruedy

Stoecker

et al. 2015

JIR

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“…Unlike most Fe enzymes, ribonucleotide reductase has a relatively-low affinity for Fe and its activity will be lost readily as Fe availability declines in vivo, but in cultures it may be reactivated by adventitious Fe present in the medium. Humoral immunity appears relatively little affected by either Fe or Zn deficiency, but the latter does inhibit the cell-mediated response possibly through loss of the Zn-dependent peptide, thymulin, which is required for the differentiation of T-lymphocytes (Dardenne et al 1982(Dardenne et al , 1984Fraker et al 1984;Mercalli et al 1984). This view is strengthened by the observation that when T-lymphocyte numbers were reduced by Zn deficiency the proportion of Thelper cells within the population remained unaltered, suggesting a uniform effect on the differentiation of all types of T-cell (Dowd et al 1986).…”

Section: M M U N I T Ymentioning

confidence: 99%

Early Biochemical Defects Caused by Dietary Trace Element Deficiencies

Chesters¹,

Arthur²

1988

Nutr. Res. Rev.

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Zinc and anergy in pediatric Hodgkin's disease in Turkey

Çavdar¹,

Babacan²,

Gözdaşoĝlu³

et al. 1987

Cancer

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Blood (serum, erythrocytes) and hair zinc levels were determined in 60 biopsy-proven pediatric Hodgkin's disease cases at diagnosis. Cellular immunity also was assessed through total lymphocyte counts, E-rosette formation, lymphoproliferative response (LP), and delayed cutaneous hypersensitivity tests to dinitrochlorobenzene, streptokinase-streptodornase, purified protein derivative and phytohemagglutinin (PHA) in some of these patients. Interestingly, anergic patients unresponsive to four antigens showed significantly more depressed serum zinc levels as well as decreased lymphoproliferative response to mitogen (PHA). A positive correlation could be shown between serum zinc level, cutaneous anergy and LP. A possible contributing role of zinc deficiency in defective cell mediated immunity in Hodgkin's disease was proposed, and administration of oral zinc, as a natural immunostimulant is considered in this lymphoma.

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Zinc deficiency and thymus ultrastructure in rats

Cited by 8 publications

References 7 publications

Implications of compromised zinc status on bone loss associated with chronic inflammation in C57BL/6 mice

Implications of compromised zinc status on bone loss associated with chronic inflammation in C57BL/6 mice

Early Biochemical Defects Caused by Dietary Trace Element Deficiencies

Zinc and anergy in pediatric Hodgkin's disease in Turkey

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