Zinc-containing bioactive glasses: Surface reactivity and behaviour towards endothelial cells

Aina, Valentina; Malavasi, Gianluca; Fiorio, Alessandra; Munaron, Luca; Morterra, C.

doi:10.1016/j.actbio.2008.10.020

Cited by 171 publications

(106 citation statements)

References 29 publications

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“…In agreement with published data, 30,[52][53][54][55] the dissolution study performed here demonstrated decreased Si 4+ , Ca 2+ , Na + and Co 2+ release with the addition of both Mg 2+ and Zn 2+ to the BGs (Fig. 9).…”

supporting

confidence: 93%

Synthesis and characterization of hypoxia-mimicking bioactive glasses for skeletal regeneration

et al. 2010

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The cellular response to hypoxia is vital for skeletal tissue development and regeneration. Numerous processes, including progenitor cell recruitment, proliferation and differentiation, are activated through the hypoxia pathway in a low oxygen pressure environment. Novel materials-based strategies designed to activate the hypoxia pathway are therefore of great interest for orthopaedic tissue engineering.Here resorbable bioactive glasses (BG) were designed to activate the hypoxia pathway by substitution of Co 2+ for Ca 2+ in the BG and substitution of Co 2+ and Ca 2+ /+2Na + for Si 4+ . This allowed for the controlled release of cobalt, whilst controlling BG bioactivity (apatite-forming ability). Two series of soda-lime-phosphosilicate glasses were manufactured with increasing concentrations of cobalt. Compositions were calculated to maintain constant network connectivity (2.13) by considering cobalt as an intermediate oxide in the first series, and as a network modifier in the second series. Mg 2+ and Zn 2+ were added to one of the Co 2+ -containing glasses to inhibit HCA formation since delay or inhibition of HCA formation is essential for the use of BG in soft tissues, as is the case of cartilage.Cobalt was present in both the silicate and phosphate phases of the BG. In addition, evidence was found for it playing a dual role in the silicate phase, acting as both an intermediate oxide and taking part in the network as well as being a network modifying oxide. Consistent with an intermediate oxide role, the presence of cobalt in the BG was shown to decrease ion release. HCA formation was delayed with cobalt additions. Mg 2+ and Zn 2+ further delayed HCA formation.Cobalt release was found to be proportional to cobalt content of the BGs enabling the controlled delivery of cobalt in therapeutic active doses.

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confidence: 93%

Synthesis and characterization of hypoxia-mimicking bioactive glasses for skeletal regeneration

et al. 2010

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“…Soda-lime phosphosilicate-based bioactive glasses (such as Bioglass ® 45S5) are well known to cause a pH rise upon immersion in aqueous solutions [13]. This pH increase favours apatite deposition but can negatively affect the surrounding tissue in vivo, a problem which is largely overlooked in the literature.…”

Section: Effect Of Fluoride Content On Ph Of Tris Buffermentioning

confidence: 89%

High phosphate content significantly increases apatite formation of fluoride-containing bioactive glasses

et al. 2011

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Bioactive glass-containing toothpastes for treating dentine hypersensitivity work by precipitating hydroxy-carbonate apatite (HCA) onto the tooth surface, but concerns exist over the long-term durability of HCA in the mouth. Fluoridecontaining bioactive glasses form fluorapatite (FAp) in physiological solutions, which is more chemically stable against acid attack.The influence of phosphate content on apatite formation was investigated by producing a low-phosphate (about 1 mol% P 2 O 5 ) and a high-phosphate (about 6 mol%) series of melt-derived bioactive glasses in the system SiO 2 -P 2 O 5 -CaONa 2 O; increasing amounts of CaF 2 were added by keeping the ratio of all other components constant. pH change, ion release and apatite formation during immersion in tris buffer at 37°C over up to seven days were investigated. Crystal phases formed in tris buffer were characterised using infra-red spectroscopy, X-ray diffraction and solid-state nuclear magnetic resonance.An increase in phosphate or fluoride content allowed for apatite formation at lower pH; fluoride enhanced apatite formation due to lower solubility of FAp compared to hydroxyapatite or HCA. High phosphate content glasses formed apatite significantly faster (within 6 hours) than low phosphate content glasses (within 3 days). In addition, an increase in phosphate content favoured apatite formation rather than fluorite (CaF 2 ). 19F MAS NMR showed the apatite formed by fluoride-containing glasses to be FAp, which makes these glasses of particular interest for dental applications. This study shows that by varying the phosphate content the reactivity and apatite formation of bioactive glasses can be controlled successfully.

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“…[41][42][43][44][45][46][47][48][49][50][51] Leach et al showed that scaffolds based on poly-lactic-co-glycolic acid (PLGA) coated with 0.5 mg of microparticles of 45S5 Bioglass® can stimulate the in vitro proliferation of human microvascular endothelial cells (HMVEC). 45 Leu and Leach also described an increase in cell proliferation and VEGF production in HMVEC exposed to IDPs released from collagen sponges containing 0.12 and 1.2 mg of 45S5 Bioglass® microparticles in their structure.…”

Section: Discussionmentioning

confidence: 99%

In vitro endothelial cell response to ionic dissolution products from boron-doped bioactive glass in the SiO₂–CaO–P₂O₅–Na₂O system

et al. 2014

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As it has been established that boron (B) may perform functions in angiogenesis and osteogenesis, the controlled and localized release of B ions from bioactive glasses (BGs) is expected to provide a promising therapeutic alternative for regenerative medicine of vascularized tissues, such as bone. The aim of this study was to assess the in vitro angiogenic effects of the ionic dissolution products (IDPs) from BGs in the SiO 2 -CaO-Na 2 O-P 2 O 5 (45S5) system and of those from 45S5 BG doped with 2 wt%

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Zinc-containing bioactive glasses: Surface reactivity and behaviour towards endothelial cells

Cited by 171 publications

References 29 publications

Synthesis and characterization of hypoxia-mimicking bioactive glasses for skeletal regeneration

Synthesis and characterization of hypoxia-mimicking bioactive glasses for skeletal regeneration

High phosphate content significantly increases apatite formation of fluoride-containing bioactive glasses

In vitro endothelial cell response to ionic dissolution products from boron-doped bioactive glass in the SiO₂–CaO–P₂O₅–Na₂O system

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Zinc-containing bioactive glasses: Surface reactivity and behaviour towards endothelial cells

Cited by 171 publications

References 29 publications

Synthesis and characterization of hypoxia-mimicking bioactive glasses for skeletal regeneration

Synthesis and characterization of hypoxia-mimicking bioactive glasses for skeletal regeneration

High phosphate content significantly increases apatite formation of fluoride-containing bioactive glasses

In vitro endothelial cell response to ionic dissolution products from boron-doped bioactive glass in the SiO2–CaO–P2O5–Na2O system

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In vitro endothelial cell response to ionic dissolution products from boron-doped bioactive glass in the SiO₂–CaO–P₂O₅–Na₂O system