Zinc Complexes Derived from 5-Bromo-2-(((2-isopropylamino)ethyl)imino)methyl)phenol: Microwave-Assisted Synthesis, Characterization, Crystal Structures and Antibacterial Activities

Abstract

Three new zinc complexes [Zn3L2(μ2-η1:η1-CH3COO)2(μ2-η2:η0-CH3COO)2] (1), [ZnCl2(HL)] (2) and [ZnBr2(HL)] (3), where L = 5-bromo-2-(((2-isopropylamino)ethyl)imino)methyl)phenolate, HL = 5-bromo-2-(((2-isopropylammonio) ethyl)imino)methyl)phenolate, have been synthesized under microwave irradiation. The complexes were characterized by elemental analyses, IR, UV-Vis spectra, molar conductivity, and single crystal X-ray diffraction. X-ray analysis revealed that the Zn atoms in complex 1 are in square pyramidal and octahedral coordination, and those in complexes 2 and 3 are in tetrahedral coordination. The molecules of the complexes are linked through hydrogen bonds and π···π interactions. In order to evaluate the biological activity of the complexes, in vitro antibacterial against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa was assayed.

Synthesis, Characterization, Anti-Glycation, and Anti-Oxidant Activities of Sulfanilamide Schiff Base Metal Chelates

“…12 Copper(II), zinc(II), vanadium(V) and oxidovanadium(V) metal complexes have been reported for their excellent antibacterial urease enzyme inhibition and catalytic properties. [13][14][15][16][17] According to the literature, sulfonamides have a variety of bioactivities, including antitumor, antimalarial, antimicrobial, antithyroid, antidiabetic, anti-HIV/AIDS, anti-parasitic, antiepileptic, and dihydropteroate synthetase inhibitors activities. [18][19][20][21] Sulfonamide metal chelates derivatives have also been reported for their anti-inflammatory, antidiabetic, anti-HIV, anticancer, anticarbonic anhydrase, diuretic, hypoglycemic, antithyroid, antimalarial, antitumor, anti-angiogenic, anti-tubercular, antibacterial, and antifungal activities.…”