Zinc-based metal-organic frameworks: synthesis and recent progress in biomedical application

Moharramnejad, Mojtaba; Ehsani, Ali; salmani, Saba; Shahi, Mehrnaz; Malekshah, Rahime Eshaghi; Robatjazi, Zahra Sadat; Parsimehr, Hamidreza

doi:10.1007/s10904-022-02385-y

“…Despite hydrogen and other bondings, van der Waal and π-π electrostatic interactions load anti-cancer agents or drugs [96]. Copper and zinc ions are endogenously non-toxic transition-metal cations [127]. The common organic ligands are benzene 1,3,5-tricarboxylate (BTC) and tetrakis (4-carboxyphenyl) porphyrin (TCPP) for copper and zeolitic imidazolate (ZIF) for zinc [117].…”

Section: Copper and Zinc Ions In Metal-organic Framework Structuresmentioning

confidence: 99%

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

Zaidi¹,

Miskon²

2023

Preprint

0

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Due to its built-up chemoresistance after prolonged usage, the demand for replacing platinum in metal-based drugs (MBD) is rising. The first MBD approved by the FDA for cancer therapy was cisplatin in 1978. Even after nearly four and a half decades of trials, there has been no significant improvement in osteosarcoma (OS) therapy. In fact, many MBD have been developed, but the chemoresistance problem raised by platinum remains unresolved. This motivates us to elucidate the possibilities of the copper and zinc (CuZn) combination to replace platinum in MBD. Thus, the anti-chemoresistance properties of CuZn and their physiological functions for OS therapy are highlighted. Herein, we summarise their chelators, main organic solvents, and ligand functions in their structures that are involved in anti-chemoresistance properties. Through this review, it is rational to discuss their ligands’ roles as biosensors in drug delivery systems. Hereafter, an in-depth understanding of their redox and photoactive function relationships is provided. The disadvantage is that the other functions of biosensors cannot be elaborated on here. As a result, this review is being developed, which is expected to intensify OS drugs with higher cure rates. Nonetheless, this advancement intends to solve the major chemoresistance obstacle towards clinical efficacy.

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“…Despite hydrogen and other bondings, van der Waal and π-π electrostatic interactions load anti-cancer agents or drugs [ 123 ]. Copper and zinc ions are endogenously non-toxic transition-metal cations [ 124 ]. The common organic ligands are benzene 1,3,5-tricarboxylate (BTC) and tetrakis (4-carboxyphenyl) porphyrin (TCPP) for copper and zeolitic imidazolate (ZIF) for zinc [ 112 ].…”

Section: Copper Zinc and Cuzn Structures In Anti-chemoresistancementioning

confidence: 99%

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

Zaidi

¹

,

Miskon

²

2023

Molecules

16

0

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Due to its built-up chemoresistance after prolonged usage, the demand for replacing platinum in metal-based drugs (MBD) is rising. The first MBD approved by the FDA for cancer therapy was cisplatin in 1978. Even after nearly four and a half decades of trials, there has been no significant improvement in osteosarcoma (OS) therapy. In fact, many MBD have been developed, but the chemoresistance problem raised by platinum remains unresolved. This motivates us to elucidate the possibilities of the copper and zinc (CuZn) combination to replace platinum in MBD. Thus, the anti-chemoresistance properties of CuZn and their physiological functions for OS therapy are highlighted. Herein, we summarise their chelators, main organic solvents, and ligand functions in their structures that are involved in anti-chemoresistance properties. Through this review, it is rational to discuss their ligands’ roles as biosensors in drug delivery systems. Hereafter, an in-depth understanding of their redox and photoactive function relationships is provided. The disadvantage is that the other functions of biosensors cannot be elaborated on here. As a result, this review is being developed, which is expected to intensify OS drugs with higher cure rates. Nonetheless, this advancement intends to solve the major chemoresistance obstacle towards clinical efficacy.

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“…For centuries, the ancient Greek, classic Roman, and Islamic empires created the agricultural revolution by performing catalysis through controlled ammonia synthesis. Commercial production of base chemicals with large-scale production such as sulfuric acid by catalytic processes started the industrial revolution. ,− Due to their large-scale applications of catalysts, high price, and scarce reserves, development of a cost-effective, high-activity, nonprecious metal-based electrocatalysts is urgent because of enhanced activities, high stability, and catalytic activity. − …”

Section: Introductionmentioning

confidence: 99%

“…MOFs can consist of inorganic nodes (metal ions or clusters) and multitopic organic molecules (linkers) via self-assembly to make porous materials . In order to fabricate MOFs, various inorganic and organic techniques are used for diversifying building blocks with different properties that applied to specific targets. ,− Compared to other porous materials, MOFs have been widely used for applications in the arena of gas storage and separation, ion exchange, drug delivery, luminescence, sensing, nanofilters, water purification, and catalysis due to their distinct pore structures. ,,− Among a wide range of MOFs, MOF based on Fe [MIL-100 (Fe)] exhibited great potential as the photocatalytic and absorption activities target molecules because of their best bandgap and strong affinity with aromatic species but limited the donor–acceptor interactions of guest molecules in the photocatalytic reactions. So, the pore structure regulation of MOFs has been required in catalyzing the gas-phase reaction. , MOF composites are designed for a wider range of various heterogeneous catalytic reactions for alcohol oxidation by oxidant and detoxification properties to olefin oligomerization .…”

Section: Introductionmentioning

confidence: 99%

MOFs as Versatile Catalysts: Synthesis Strategies and Applications in Value-Added Compound Production

Malekshah

¹

,

Moharramnejad

²

,

Gharanli

³

et al. 2023

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Catalysts played a crucial role in advancing modern human civilization, from ancient times to the industrial revolution. Due to high cost and limited availability of traditional catalysts, there is a need to develop cost-effective, high-activity, and nonprecious metal-based electrocatalysts. Metal−organic frameworks (MOFs) have emerged as an ideal candidate for heterogeneous catalysis due to their physicochemical properties, hybrid inorganic/organic structures, uncoordinated metal sites, and accessible organic sections. MOFs are high nanoporous crystalline materials that can be used as catalysts to facilitate polymerization reactions. Their chemical and structural diversity make them effective for various reactions compared to traditional catalysts. MOFs have been applied in gas storage and separation, ion-exchange, drug delivery, luminescence, sensing, nanofilters, water purification, and catalysis. The review focuses on MOF-enabled heterogeneous catalysis for value-added compound production, including alcohol oxidation, olefin oligomerization, and polymerization reactions. MOFs offer tunable porosity, high spatial density, and single-crystal XRD control over catalyst properties. In this review, MOFs were focused on reactions of CO 2 fixation, CO 2 reduction, and photoelectrochemical water splitting. Overall, MOFs have great potential as versatile catalysts for diverse applications in the future.

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Zinc-based metal-organic frameworks: synthesis and recent progress in biomedical application

Cited by 30 publications

References 100 publications

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

MOFs as Versatile Catalysts: Synthesis Strategies and Applications in Value-Added Compound Production

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