Zinc associated nanomaterials and their intervention in emerging respiratory viruses: Journey to the field of biomedicine and biomaterials

Rodelo, Citlaly Gutiérrez; Salinas, Rafael A.; Armenta-Jaime, Erika; Armenta, Silvia; Galdámez‐Martínez, Andrés; Castillo‐Blum, Silvia E.; Vega, Horacio Astudillo‐de la; Grace, Andrews Nirmala; Aguilar-Salinas, Carlos A.; Rodelo, Juliana Gutiérrez; Christie, Graham; Alsanie, Walaa F.; Santana, G.; Thakur, Vijay Kumar; Dutt, A.

doi:10.1016/j.ccr.2021.214402

Cited by 33 publications

(23 citation statements)

References 248 publications

(352 reference statements)

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“…Additionally, a recent report hypothesized virus inactivation by Zn 2+ release and ROS formation. Specifically, four mechanisms were described as the most probable: (i) ZnO nanostructures for the possible anchoring of SARS-CoV-2 virions, thus inhibiting interaction with host cell receptors; (ii) internalization of ZnO nanostructures for the inhibition of early stages of the viral replication cycle; (iii) ion release as a surface attack mechanism to disrupt the plasmid and RNA virus integrity; (iv) photocatalytic generation of reactive oxygen species for the possible degradation of the lipid, protein, and nucleic structure of SARS-CoV-2 [ 32 ].…”

Section: Resultsmentioning

confidence: 99%

On the Efficacy of ZnO Nanostructures against SARS-CoV-2

Sportelli

Izzi

Loconsole

et al. 2022

IJMS

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In 2019, the new coronavirus disease (COVID-19), related to the severe acute respiratory syndrome coronavirus (SARS-CoV-2), started spreading around the word, giving rise to the world pandemic we are still facing. Since then, many strategies for the prevention and control of COVID-19 have been studied and implemented. In addition to pharmacological treatments and vaccines, it is mandatory to ensure the cleaning and disinfection of the skin and inanimate surfaces, especially in those contexts where the contagion could spread quickly, such as hospitals and clinical laboratories, schools, transport, and public places in general. Here, we report the efficacy of ZnO nanoparticles (ZnONPs) against SARS-CoV-2. NPs were produced using an ecofriendly method and fully characterized; their antiviral activity was tested in vitro against SARS-CoV-2, showing a decrease in viral load between 70% and 90%, as a function of the material’s composition. Application of these nano-antimicrobials as coatings for commonly touched surfaces is envisaged.

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Section: Resultsmentioning

confidence: 99%

On the Efficacy of ZnO Nanostructures against SARS-CoV-2

Sportelli

Izzi

Loconsole

et al. 2022

IJMS

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“…It impacts bacterial cells via the two methods discussed above by adhering to membranes, changing their potential and integrity, and triggering ROS production. As a result, the Zn NM is also a mutagen, albeit a weak one . The relations between these unusual materials and bacteria are mainly harmful, which has led to antimicrobial uses in the food business as multiple researchers have revealed that ZnO NPs are nontoxic to living organisms .…”

Section: Widely Used Nanoparticle(s) For Deactivating Bioaerosols Wit...mentioning

confidence: 99%

“…As a result, the Zn NM is also a mutagen, albeit a weak one. 103 The relations between these unusual materials and bacteria are mainly harmful, which has led to antimicrobial uses in the food business as multiple researchers have revealed that ZnO NPs are nontoxic to living organisms. 104 This necessitates their use as antibacterial drugs that are toxic to microbes and have good biocompatibility with human cells.…”

Section: Importance Of Nanotechnology For Deactivating Bioaerosols (I...mentioning

confidence: 99%

Antimicrobial Nanomaterials as Advanced Coatings for Self-Sanitizing of Textile Clothing and Personal Protective Equipment

2023

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Controlling bioaerosols has become increasingly critical in affecting human health. Natural product treatment in the nano form is a potential method since it has lower toxicity than inorganic nanomaterials like silver nanoparticles. This research is important for the creation of a bioaerosol control system that is effective. Nanoparticles (NPs) are gradually being employed to use bacteria as a nonantibiotic substitute for treating bacterial infections. The present study looks at nanoparticles’ antimicrobial properties, their method of action, their impact on drug-opposing bacteria, and the hazards connected with their operation as antimicrobial agents. The aspects that influence nanoparticle conduct in clinical settings, as well as their distinctive features and mode of action as antibacterial assistants, are thoroughly examined. Nanoparticles’ action on bacterial cells is presently accepted by way of the introduction of oxidative stress induction, metal-ion release, and nonoxidative methods. Because many concurrent mechanisms of action against germs would necessitate multiple simultaneous gene modifications in the same bacterial cell for antibacterial protection to evolve, bacterial cells developing resistance to NPs is difficult. This review discusses the antimicrobial function of NPs against microbes and presents a comprehensive discussion of the bioaerosols: their origin, hazards, and their prevention. This state of the art method is dependent upon the use of personal protective gear against these bioaerosols. The benefit of the utmost significant categories of metal nanoparticles as antibacterial agents is given important consideration. The novelty of this review depends upon the antimicrobial properties of (a) silver (Ag), (b) zinc oxide (ZnO), and (c) copper oxide (CuO) nanoparticles. The value-added features of these nanoparticles are discussed, as well as their physicochemical characterization and pharmacokinetics, including the toxicological danger they pose to people. Lastly, the effective role of nanomaterials and their future in human wellness is discussed.

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“…COVID-19 has wreaked havoc on the worldwide economy and health system, resulting in >5 million lives lost [65] and enormous economic and social upheaval. Similarly, an Ebola epidemic began in middle Africa in 2013 and expanded to neighboring nations in Western Africa, resulting in 28,652 human infections and 11,325 lives lost between 2013 and 2016 [66].…”

Section: Covid-19mentioning

confidence: 99%

Heavy Metal, Waste, COVID-19, and Rapid Industrialization in This Modern Era—Fit for Sustainable Future

Adnan

Xiao

et al. 2022

Sustainability

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Heavy metal contamination, waste, and COVID-19 are hazardous to all living things in the environment. This review examined the effects of heavy metals, waste, and COVID-19 on the ecosystem. Scientists and researchers are currently working on ways to extract valuable metals from waste and wastewater. We prefer Tessier sequential extraction for future use for heavy metal pollution in soil. Results indicated that population growth is another source of pollution in the environment. Heavy metal pollution wreaks havoc on soil and groundwater, especially in China. COVID-19 has pros and cons. The COVID-19 epidemic has reduced air pollution in China and caused a significant reduction in CO2 releases globally due to the lockdown but has a harmful effect on human health and the economy. Moreover, COVID-19 brings a huge amount of biomedical waste. COVID-19’s biomedical waste appears to be causing different health issues. On the other hand, it was discovered that recycling has become a new source of pollution in south China. Furthermore, heavy metal contamination is the most severe ecological effect. Likewise, every problem has a remedy to create new waste management and pollution monitoring policy. The construction of a modern recycling refinery is an important aspect of national waste disposal.

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Zinc associated nanomaterials and their intervention in emerging respiratory viruses: Journey to the field of biomedicine and biomaterials

Cited by 33 publications

References 248 publications

On the Efficacy of ZnO Nanostructures against SARS-CoV-2

On the Efficacy of ZnO Nanostructures against SARS-CoV-2

Antimicrobial Nanomaterials as Advanced Coatings for Self-Sanitizing of Textile Clothing and Personal Protective Equipment

Heavy Metal, Waste, COVID-19, and Rapid Industrialization in This Modern Era—Fit for Sustainable Future

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