Zinc and Total Parenteral Nutrition

Dd, Michie; Macfarlane,; Fh, Wirth

doi:10.1097/00007611-197708000-00025

Cited by 6 publications

(2 citation statements)

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“…Recommendations for stable adult patients range from 2.5 to 4.0 mg/day. Under conditions of stress, such as surgery and burns, TPN supplementation requirements may be higher because of increased catabolism, excretion or both (36). Thus, for adults in an acute catabolic state an additional 2.0 mg zinc should be added, increasing the daily intravenous infusion to 4.5 to 6.0 mg (34).…”

Section: Treatment Of Zinc Deficiencymentioning

confidence: 99%

Clinical Aspects of Trace Elements: Zinc in Human Nutrition – Zinc Deficiency and Toxicity

Pluhator

Thomson

Fedorak

1996

Canadian Journal of Gastroenterology and Hepatology

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Available evidence suggests that trace elements, such as zinc, once thought to have no nutritional relevance, are possibly deficient in large sections of the human population. Conditioned deficiencies have been reported to result from malabsorption syndromes, acrodermatitis enteropathica, alcoholism, gastrointestinal disease, thermal injury, chronic diseases (eg, diabetes, sickle cell anemia), and in total parenteral nutrition therapy. Awareness that patients with these problems are at risk has led health professionals to focus increasingly on the importance of zinc therapy in the prevention and treatment of deficiency. More recently zinc toxicity and its role in human nutrition and well-being have come under investigation. Reports have focused on the role of zinc toxicity in causes of copper deficiency, changes in the immune system and alterations in blood lipids. As the numerous challenges presented by the study of zinc in human nutrition are met, more appropriate recommendations for dietary and therapeutic zinc intake are being made.

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Section: Treatment Of Zinc Deficiencymentioning

confidence: 99%

Clinical Aspects of Trace Elements: Zinc in Human Nutrition – Zinc Deficiency and Toxicity

Pluhator

Thomson

Fedorak

1996

Canadian Journal of Gastroenterology and Hepatology

View full text Add to dashboard Cite

show abstract

“…The importance of trace elements such as zinc to complete nutrition has been shown by the requirement for its inclusion in total parenteral nutrition formulations. 6 , 7 In addition, it has been recognized that patients with PAD taking certain antihypertensive medications such as an angiotensin receptor blocker, thiazide, angiotensin-converting enzyme inhibitor, or potassium-sparing diuretics might develop a net negative zinc balance that could necessitate monitoring and nutritional supplementation. 8 What is unknown, however, is the role and mechanisms of trace elements, most of which serve as co-factors for essential enzymatic processes, in the management of PAD.…”

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confidence: 99%