Zinc and Selenium in Inflammatory Bowel Disease: Trace Elements with Key Roles?

Vaghari‐Tabari, Mostafa; Jafari-Gharabaghlou, Davoud; Sadeghsoltani, Fatemeh; Hassanpour, Parisa; Qujeq, Durdi; Rashtchizadeh, Nadereh; Ghorbanihaghjo, Amir

doi:10.1007/s12011-020-02444-w

Cited by 43 publications

(20 citation statements)

References 164 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent epidemiological studies have reported that a selenium deficiency in patients with inflammatory bowel diseases (IBDs) [ 38 , 117 ] was related to an increased severity of Crohn’s disease and ulcerative colitis. Although IBDs have a multifactorial pathogenesis and different symptoms, they share a common chronic inflammatory condition of the intestine.…”

Section: Inflammatory Statesmentioning

confidence: 99%

“…If adequate levels of selenium are available, Nrf2 can enter the nucleus and bind to antioxidant/electrophile responsive element (ARE/EpRE) regions to enhance the expression of antioxidant genes, including GPxs and TrxRs. These selenoproteins combat oxidative stress, attenuate inflammatory signalling pathways, and increase the population of anti-inflammatory M2 macrophages, helping patients to extend the remission phase [ 117 ]. Dietary selenium and selenoproteins have been observed to modulate specific pathways associated with such diseases.…”

Section: Inflammatory Statesmentioning

confidence: 99%

See 1 more Smart Citation

The Role of Selenium in Pathologies: An Updated Review

2022

View full text Add to dashboard Cite

Selenium is an essential microelement required for a number of biological functions. Selenium—and more specifically the amino acid selenocysteine—is present in at least 25 human selenoproteins involved in a wide variety of essential biological functions, ranging from the regulation of reactive oxygen species (ROS) concentration to the biosynthesis of hormones. These processes also play a central role in preventing and modulating the clinical outcome of several diseases, including cancer, diabetes, Alzheimer’s disease, mental disorders, cardiovascular disorders, fertility impairments, inflammation, and infections (including SARS-CoV-2). Over the past years, a number of studies focusing on the relationship between selenium and such pathologies have been reported. Generally, an adequate selenium nutritional state—and in some cases selenium supplementation—have been related to improved prognostic outcome and reduced risk of developing several diseases. On the other hand, supra-nutritional levels might have adverse effects. The results of recent studies focusing on these topics are summarized and discussed in this review, with particular emphasis on advances achieved in the last decade.

show abstract

Section: Inflammatory Statesmentioning

confidence: 99%

Section: Inflammatory Statesmentioning

confidence: 99%

The Role of Selenium in Pathologies: An Updated Review

2022

View full text Add to dashboard Cite

show abstract

“…The study further recommended that zinc levels should be assessed at the time of diagnosis, so that enteral repletion may commence in cases of deficiency [ 52 ]. Zinc had been also found to regulate the inflammation process and antioxidant effects via the activation of Nf-κB and SOD1 signaling pathways, by which it might impact IBD pathogenesis [ 53 , 54 , 55 ]. Despite these evidently crucial roles of zinc, the status of this trace element in IBD has not been conclusively researched; however, it has been widely asserted that zinc supplements may be effective in its treatment.…”

Section: Intestinal Microbiota and Ibdmentioning

confidence: 99%

Dietary Regulation of the Crosstalk between Gut Microbiome and Immune Response in Inflammatory Bowel Disease

Yao

Fan

et al. 2021

Foods

View full text Add to dashboard Cite

Inflammatory bowel disease (IBD), a chronic, recurring inflammatory response, is a growing global public health issue. It results from the aberrant crosstalk among environmental factors, gut microbiota, the immune system, and host genetics, with microbiota serving as the core of communication for differently-sourced signals. In the susceptible host, dysbiosis, characterized by the bloom of facultative anaerobic bacteria and the decline of community diversity and balance, can trigger an aberrant immune response that leads to reduced tolerance against commensal microbiota. In IBD, such dysbiosis has been profoundly proven in animal models, as well as clinic data analysis; however, it has not yet been conclusively ascertained whether dysbiosis actually promotes the disease or is simply a consequence of the inflammatory disorder. Better insight into the complex network of interactions between food, the intestinal microbiome, and host immune response will, therefore, contribute significantly to the diagnosis, treatment, and management of IBD. In this article, we review the ways in which the mutualistic circle of dietary nutrients, gut microbiota, and the immune system becomes anomalous during the IBD process, and discuss the roles of bacterial factors in shaping the intestinal inflammatory barrier and adjusting immune capacity.

show abstract

“…Although this enzyme is primarily cytosolic, it is also located in mitochondria and is in charge of metabolizing the superoxide anion, which is a harmful free radical that is abundantly produced during mitochondrial dysfunction observed in oxidative/inflammatory diseases. For this reason, zinc deficiency is usually associated with the increased generation of free radicals and uncontrolled inflammation, as happens in inflammatory bowel disease [ 173 , 174 ]. Similar to melatonin, zinc also attenuates the mitochondrial dysfunction, autophagy, and exacerbated inflammation observed during osteoarthritis, slowing the progression of this oxidative/inflammatory pathology [ 175 ].…”

Section: Contribution Of Micronutrients To the Therapy Of Oxidative/inflammatory Diseases Through Their Mitochondrial Actionsmentioning

confidence: 99%

Potential Effects of Melatonin and Micronutrients on Mitochondrial Dysfunction during a Cytokine Storm Typical of Oxidative/Inflammatory Diseases

et al. 2021

View full text Add to dashboard Cite

Exaggerated oxidative stress and hyper-inflammation are essential features of oxidative/inflammatory diseases. Simultaneously, both processes may be the cause or consequence of mitochondrial dysfunction, thus establishing a vicious cycle among these three factors. However, several natural substances, including melatonin and micronutrients, may prevent or attenuate mitochondrial damage and may preserve an optimal state of health by managing the general oxidative and inflammatory status. This review aims to describe the crucial role of mitochondria in the development and progression of multiple diseases as well as the close relationship among mitochondrial dysfunction, oxidative stress, and cytokine storm. Likewise, it attempts to summarize the main findings related to the powerful effects of melatonin and some micronutrients (vitamins and minerals), which may be useful (alone or in combination) as therapeutic agents in the treatment of several examples of oxidative/inflammatory pathologies, including sepsis, as well as cardiovascular, renal, neurodegenerative, and metabolic disorders.

show abstract

Zinc and Selenium in Inflammatory Bowel Disease: Trace Elements with Key Roles?

Cited by 43 publications

References 164 publications

The Role of Selenium in Pathologies: An Updated Review

The Role of Selenium in Pathologies: An Updated Review

Dietary Regulation of the Crosstalk between Gut Microbiome and Immune Response in Inflammatory Bowel Disease

Potential Effects of Melatonin and Micronutrients on Mitochondrial Dysfunction during a Cytokine Storm Typical of Oxidative/Inflammatory Diseases

Contact Info

Product

Resources

About