Zinc and Neurogenesis: Making New Neurons from Development to Adulthood

Levenson, Cathy W.; Morris, Deborah R.

doi:10.3945/an.110.000174

Cited by 131 publications

(73 citation statements)

References 35 publications

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“…In comparison to previous studies in adult brain, we found higher levels of zinc in cerebral organoids, although compatible in scale of dosage (Table 2). While higher concentrations of zinc in adult brain are toxic to neural cells and also cause axonal degeneration in mice (47), zinc modulates the proliferation of stem cells and neuronal differentiation during neurogenesis (31)(32)(33). In accordance, previous data from our group have demonstrated increased zinc during neural differentiation of human pluripotent stem cells (48), which may highlight the importance of zinc for the commitment of neural stem cells and justify why levels found in cerebral organoids are subtly higher than those described in the adult brain (Table 2) (9,49,50).…”

Section: Implications Of Trace Elements Detected In Cerebral Organoidmentioning

confidence: 99%

Trace elements during primordial plexiform network formation in human cerebral organoids

Sartore

Cardoso

Lages

et al. 2016

Preprint

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Systematic studies of micronutrients during brain formation are hindered by restrictions to animal models and adult post-mortem tissues. Recently, advances in stem cell biology have enabled recapitulation of the early stages of human telencephalon development. In the present work, we exposed cerebral organoids derived from human pluripotent stem cells to synchrotron radiation in order to measure how biologically valuable micronutrients are incorporated and distributed in the exogenously developing brain. Our findings indicate that elemental inclusion in organoids is consistent with human brain tissue and involves calcium, iron, phosphorus, potassium, sulfur, and zinc. Local trends in concentrations suggest a switch from passive to actively mediated transport across cell membranes. Finally, correlational analysis for pairs of elements shows spatially conserved patterns, suggesting they may physically associate, be stored in similar compartments or used in related biological processes. These findings might reflect which trace elements are important during human brain development and will support studies aimed to unravel the consequences of disrupted metal homeostasis for neurodevelopmental diseases, including those manifested in adulthood.PeerJ Preprints | https://doi.org/10.7287/peerj.preprints.2126v1 | CC BY 4.0 Open Access |

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Section: Implications Of Trace Elements Detected In Cerebral Organoidmentioning

confidence: 99%

Trace elements during primordial plexiform network formation in human cerebral organoids

Sartore

Cardoso

Lages

et al. 2016

Preprint

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“…All very-low-birth-weight (VLBW) 4 neonates (birth weight: 401-1500 g or a gestational age of 24 to 32 wk), consecutively observed in a neonatal intensive care unit, were considered eligible for the study. Exclusion criteria were as follows: congenital or maternal infections, immunodeficiency, malformations, syndromes, genetic defects, evidence of infection, and necrotizing enterocolitis (NEC) diagnosed before enrollment, critically ill conditions (defined as a blood pH ,6.8 or hypoxia with persistent bradycardia for $1 h), and hospitalization for ,1 wk.…”

Section: Participantsmentioning

confidence: 99%

“…It is required for the production of a wide variety of enzymes involved in essential metabolic patterns (ie, protein synthesis, nucleic acid metabolism, immune function, and organogenesis) (1)(2)(3). Zinc is crucial for the development of the brain, respiratory and intestinal tracts in pre-and postnatal life (1,(4)(5)(6)(7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Zinc supplementation reduces morbidity and mortality in very-low-birth-weight preterm neonates: a hospital-based randomized, placebo-controlled trial in an industrialized country

Terrin¹,

Canani²,

Passariello³

et al. 2013

The American Journal of Clinical Nutrition

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Background: Zinc plays a pivotal role in the pathogenesis of many diseases and in body growth. Preterm neonates have high zinc requirements. Objective: The objective of the study was to investigate the efficacy of zinc supplementation in reducing morbidity and mortality in preterm neonates and to promote growth. Design: This was a prospective, double-blind, randomized controlled study of very-low-birth-weight preterm neonates randomly allocated on the seventh day of life to receive (zinc group) or not receive (control group) oral zinc supplementation. Total prescribed zinc intake ranged from 9.7 to 10.7 mg/d in the zinc group and from 1.3 to 1.4 mg/d in the placebo control group. The main endpoint was the rate of neonates with $1 of the following morbidities: lateonset sepsis, necrotizing enterocolitis, bronchopulmonary dysplasia, periventricular leucomalacia, and retinopathy of prematurity. Secondary outcomes were mortality and body growth. Results: We enrolled 97 neonates in the zinc group and 96 in the control group. Morbidities were significantly lower in the zinc group (26.8% compared with 41.7%; P = 0.030). The occurrence of necrotizing enterocolitis was significantly higher in the control group (6.3% compared with 0%; P = 0.014). Mortality risk was higher in the placebo control group (RR: 2.37; 95% CI: 1.08, 5.18; P = 0.006). Daily weight gain was similar in the zinc (18.2 6 5.6 g $ kg 21 $ d 21 ) and control (17.0 6 8.7 g $ kg 21 $ d 21

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“…However, more than 30% of the world's population is Zn deficient, including around 10% of Spain and Portugal (Hotz and Brown 2004;WHO 2009). A deficient Zn intake by humans is associated with severe health complications, including impairments of physical growth, immune system and learning ability, combined with increased risk of infections, DNA damage and cancer development (Hotz and Brown 2004;Levenson and Morris 2011). The European Recommended Dietary Intake (RDI) of Zn for humans is 15 mg Zn day -1 (Elmadfa 2009).…”

Section: Introductionmentioning

confidence: 99%

Combined zinc and nitrogen fertilization in different bread wheat genotypes grown under mediterranean conditions

Gomez-Coronado¹,

Poblaciones²,

Almeida³

et al. 2017

Cereal Research Communications

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The combined application of nitrogen (N) and zinc (Zn) appears to be a promising agronomic strategy for the biofortification with Zn. To evaluate such efficiency, a field experiment was conducted in south-eastern Portugal under Zn-deficient soil. Four advanced breeding lines and two commercial varieties of bread wheat (Triticum aestivum L.) were fertilized with five treatments: i) control, ii) two foliar Zn applications, iii) one foliar Zn+N application, iv) soil and two foliar Zn applications, and v) soil and one foliar Zn+N application. Grain Zn content varied greatly across treatments and INIAV-1 and the commercial varieties were the most interesting cultivars in all the treatments. Grain Zn concentrations higher than the target level of 38 mg Zn kg -1 were obtained only when two foliar Zn applications were applied, alone or in combination with soil Zn applications, and grain Zn bioavailability also was more adequate (phytate:Zn ratios similar to 15). Soil Zn application resulted in grain yield increases between 7-10%, which virtually offset the extra application cost. The combined soil and two foliar treatment could be a good option for biofortifying bread wheat under Zn-deficient soils.

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Zinc and Neurogenesis: Making New Neurons from Development to Adulthood

Cited by 131 publications

References 35 publications

Trace elements during primordial plexiform network formation in human cerebral organoids

Trace elements during primordial plexiform network formation in human cerebral organoids

Zinc supplementation reduces morbidity and mortality in very-low-birth-weight preterm neonates: a hospital-based randomized, placebo-controlled trial in an industrialized country

Combined zinc and nitrogen fertilization in different bread wheat genotypes grown under mediterranean conditions

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