Zinc and mercury complexes of benzil bis(4-methyl-3-thiosemicarbazone)

Calatayud, David G.; López‐Torres, Elena; Mendiola, M. Antonia

doi:10.1016/j.poly.2015.09.016

Cited by 10 publications

(10 citation statements)

References 34 publications

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“…[142][143][144] The weaker bond between Hg-ONO 2 is broken in these abovementioned solvents and is also supported by the conductivity measurements. [103] 6.7 | Group 13 (Gallium)…”

Section: Goldmentioning

confidence: 99%

“…A number of bisthiosemicarbazones are known with various substituents on carbon atoms of the CC linkage and amino nitrogen. [ 54,81,83–103 ] The ligands with methyl, ethyl, or phenyl substituents on CC linkage are known ( A1 – A6 ) (Chart 1). These ligands were prepared by refluxing thiosemicarbazide and 1,2‐diketone in 2:1 M ratio.…”

Section: Types Of Bisthiosemicarbazonesmentioning

confidence: 99%

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Structure and bonding trends of bisthiosemicarbazones: An overview

Ain

Sharma

2023

Applied Organom Chemis

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This review gives a comprehensive account in terms of the synthesis, characterization and biological application of bisthiosemicarbazone ligands and their metal complexes that have been reported until 2022. Their coordination chemistry with p and d block elements, where the structure is solved by single crystal X‐ray crystallography is explored. Complexes are placed group‐wise and their structure as well as bonding aspects are discussed separately. Various spectroscopic techniques for the characterization of ligands and their complexes like infrared (IR), ultraviolet‐visible (UV–Vis), electron spin resonance (ESR), and nuclear magnetic resonance (NMR) (1H, 13C, 31P, 59Co, 119Hg) are discussed. Complexes formed by bisthiosemicarbazones are generally mononuclear; however, in some cases, binuclear or polynuclear complexes have also been found. Square planar, square pyramidal, octahedral, and pentagonal pyramidal are some of the common geometries exhibited by these complexes. Structure–activity relationship was established for substituted and unsubstituted diimine bisthiosemicarbazone complexes of different metal ions. The effect of co‐ligands on biological activity is also discussed.

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“…[142][143][144] The weaker bond between Hg-ONO 2 is broken in these abovementioned solvents and is also supported by the conductivity measurements. [103] 6.7 | Group 13 (Gallium)…”

Section: Goldmentioning

confidence: 99%

Section: Types Of Bisthiosemicarbazonesmentioning

confidence: 99%

Structure and bonding trends of bisthiosemicarbazones: An overview

Ain

Sharma

2023

Applied Organom Chemis

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“…Anal. Calcd for C 12 Preparation of Zn{(C 5 H 9 )C(H)¼NN¼C(S)NHMe} 2 (2) Colorless crystals of 2 were obtained using the same method as described above. Anal.…”

Section: Synthesismentioning

confidence: 99%

“…Due to their versatile coordination chemistry and wide range of pharmacological characteristics, particularly antibacterial, antitumor and antiviral functions, aromatic thiosemicarbazones have gained significant attention among synthesis chemists . Alicyclic thiosemicarbazones, on the other hand, have been underestimated and, consequently, the true potential of thiosemicarbazones of saturated ring systems remains unexplored.…”

Section: Introductionmentioning

confidence: 99%

New anticancer zinc(II) complexes comprising thiosemicarbazones of saturated ring: structure, DNA/protein binding, DNA cleavage, topoisomerase‐1 inhibition and anti‐proliferation studies

Vikneswaran

Eltayeb

Subramaniam

et al. 2016

Applied Organom Chemis

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The reaction of the thiosemicarbazones (CH2)4CNN(H)C(S)NHR (R = H, Me) with zinc(II) acetate in methanolic solution proceeds readily under mild conditions to form stable mononuclear complexes Zn[(CH2)4CNNC(S)NHR]2. DNA interaction studies show that the zinc(II) complexes bind to DNA via groove mode and exhibit efficient DNA cleavage activity in the presence of hydrogen peroxide. Also, the complexes display a binding affinity to bovine serum albumin protein with KBSA values of ca 105 M−1. Topoisomerase catalytic inhibition studies suggest that both complexes are efficient topoisomerase‐I impeders. Furthermore, the anti‐proliferative effects of the two complexes on five human tumor cell lines (Caki‐2, MCF‐7, CaSki, NCI‐H322M and Co‐115) indicate that both complexes have the potential to act as effective anticancer drugs. Copyright © 2016 John Wiley & Sons, Ltd.

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“…Studies of semicarbazone and thiosemicarbazone ligands and their complexes with transition and non-transition metals have received considerable attention, as they possess important biological properties and structural diversities [1][2][3][4][5][6][7]. The biological activity of the ligands is often increased upon coordination to transition metals [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and structural characterization of copper(II) complexes with a tetradentate semicarbazone ligand derived from 2,5-hexadione

2019

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Four Cu(II) complexes [CuLH 2 O](ClO 4 ) 2 , 1; [CuLCl]Cl.H 2 O, 2; [CuLBr] 2 (Cu 3 Br 5 ), 3; and [CuLH 2 O](NO 3 ) 2 , 4;where L = tetradentate semicarbazone ligand, have been synthesized and characterized by elemental analysis, FT-IR and UV-Vis. The structures of compounds 1 and 3 have been determined by single-crystal X-ray diffraction analyses. In mononuclear 1, the semicarbazone, L acts as a tetradentate neutral ligand and a water molecule also coordinates to the Cu atom. There are two independent [CuL(H 2 O)] 2+ cations and four perchlorate anions in the crystallographic asymmetric unit. One of the cations has a weak interaction between its Cu atom and a O atom of an adjacent perchlorate anion. The structure of 3 contains two independent [CuLBr] + cations and a (Cu 3 Br 5 ) 2− anion. The coordination geometry around the cation's Cu(II) ion is five-coordinated square pyramidal, with L acting as a tetradentate neutral ligand and with a Br at the apical position. The Cu 3 Br 5 2− anions link to one another to form an infinite one-dimensional (Cu 3 Br 5 2− ) n chain. Furthermore, the Hirshfeld surface analyses and the 2D fingerprint plot have been discussed.

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Zinc and mercury complexes of benzil bis(4-methyl-3-thiosemicarbazone)

Cited by 10 publications

References 34 publications

Structure and bonding trends of bisthiosemicarbazones: An overview

Structure and bonding trends of bisthiosemicarbazones: An overview

New anticancer zinc(II) complexes comprising thiosemicarbazones of saturated ring: structure, DNA/protein binding, DNA cleavage, topoisomerase‐1 inhibition and anti‐proliferation studies

Synthesis and structural characterization of copper(II) complexes with a tetradentate semicarbazone ligand derived from 2,5-hexadione

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