Zinc and its role in immunity and inflammation

Bonaventura, Paola; Benedetti, Giulia; Albarède, Francis; Miossec, Pierre

doi:10.1016/j.autrev.2014.11.008

Cited by 583 publications

(466 citation statements)

References 114 publications

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“…The present study illustrated insignificant weak negative correlation between zinc level (mg/l) and both the duration of tonsillitis infection, and the recurrent tonsillitis infection. Which is similar to the observation made by Bondestam M. et al (15) in their study on serum zinc levels in patients with undue susceptibility to infections, and low serum zinc level depresses various subsets of immunity and predisposes the individual to recurrent infections (16) . Some of the authors hypothesized that since zinc deficiency increases the susceptibility of an individual to infection, oral zinc supplementation may improve the immune status and thus reduces the frequency of infection.…”

Section: Discussionsupporting

confidence: 89%

Assessment of Serum Zinc level in Sudanese Patients with Chronic Tonsillitis Infection in Khartoum State

Mohamed¹

2017

JMSCR

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Section: Discussionsupporting

confidence: 89%

Assessment of Serum Zinc level in Sudanese Patients with Chronic Tonsillitis Infection in Khartoum State

Mohamed¹

2017

JMSCR

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“…On the other hand, zinc is known to modulate some immunological parameters in vitro (Zhao, Li, Chen, Hu, & Zhao, 2016) and in broilers has a positive effect on the immunological capacity by improving the levels of immunoglobulins IgA, IgM, and IgG (Vieira et al, 2013). Zinc supplementation decreases oxidative stress markers and increases phagocytosis, Moreover, Zn promotes monocyte adhesion to endothelial cells in vitro and is important for the production of pro-inflammatory cytokines (Bonaventura, Benedetti, Albarède, & Miossec, 2015).…”

Section: Introductionmentioning

confidence: 99%

Inorganic or organic zinc and MUC-2, IgA, IL-17, TGF-β4 gene expression and sIgA secretion in broiler chickens

Levkut

Husáková

Bobíková

et al. 2017

Food and Agricultural Immunology

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The study compared the effect of dietary supplementation with an inorganic or organic source of zinc (Zn) on mucin 2 (MUC-2) and IgA gene expression, the cytokines IL-17 and TGF-β4 and the secretory IgA content (sIgA) in broiler jejunum. One-day-old chickens were fed an unsupplemented basal diet (BD) or the same BD supplemented with 30 or 70 mg/kg of added Zn from ZnSO 4 ·H 2 O or Zn chelate of glycine hydrate for 40 days. The highly expressed MUC-2 and IgA genes were observed in both groups supplemented with the low-dose Zn sources (30 mg/kg). A higher sIgA concentration was observed in both the ZnSO 4 groups and the glycine-zinc/30 mg group. Our data indicate that the organic Zn chelate has better availability than the inorganic Zn source, and the low-dose Zn diets proved to be more beneficial to the maintenance of intestinal immune homeostasis. ARTICLE HISTORY

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“…[34,35] In fact, the decrease in neutrophil count initiated by Zn supplement in this study is in agreement with previous studies that reported a potential Zn antioxidant effect by negatively affecting neutrophils and inflammatory cytokines and their generated reactive oxygen species (ROS) in normal healthy subjects. [36][37][38] In addition, lymphocytes count increased in all groups as vast majority 80-90% of RTIs are caused by viruses [39] and lymphocytosis occurs in acute viral infections. [40] The major increase was in zinc group.…”

Section: Discussionmentioning

confidence: 96%

The effect of zinc and Vitamin A supplements in treating and reducing the incidence of upper respiratory tract infections in children

Shaker¹,

Fathy²,

Abdelall³

et al. 2018

Natl J Physiol Pharm Pharmacol

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Background: Supplementation of zinc and Vitamin A shows inconsistent effects on the respiratory morbidity in children in developing countries. Aims and Objectives: The aim of this study is to evaluate the effect of zinc and zinc + Vitamin A supplementation on the acute upper respiratory infections (AURTIs) in the pediatric patients aged between 2 and 12 years. Materials and Methods: A randomized double-blind placebo-controlled trial was employed in the present study. A total of 80 children suffering with AURTI were randomly assigned to one of three intervention groups: Placebo group, daily zinc (2-2.5 mg elemental zinc/Kg divided on 1-3 doses) group, and daily zinc + once dosing of Vitamin A (50000 IU) group in addition to the required treatment for their respiratory illness. Differential blood count analysis and C-reactive protein (C-RP) were assayed on days 1 and 5, and then, zinc or placebo was given daily for 6 months to the children, which were followed up and monitored once weekly for 6 months. The information regarding adverse effects, AURTI incidence, and missing school days were then collected. Results: The total white blood cells count, neutrophil (staph) percentage, and C-RP significantly decreased by post-supplementation with both zinc and zinc + Vitamin A. Monocytes percentage showed a significant increase by post-supplementation with zinc + Vitamin A (P = 0.011). In addition, AURTI and school absence incidences were significantly decreased in both zinc and zinc + Vitamin A recipients compared to placebo patients. Conclusion: We concluded that zinc alone or simultaneous zinc and Vitamin A supplementation in AURTI patients significantly improved the clinical outcome by improving the immune status.

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Zinc and its role in immunity and inflammation

Cited by 583 publications

References 114 publications

Assessment of Serum Zinc level in Sudanese Patients with Chronic Tonsillitis Infection in Khartoum State

Assessment of Serum Zinc level in Sudanese Patients with Chronic Tonsillitis Infection in Khartoum State

Inorganic or organic zinc and MUC-2, IgA, IL-17, TGF-β4 gene expression and sIgA secretion in broiler chickens

The effect of zinc and Vitamin A supplements in treating and reducing the incidence of upper respiratory tract infections in children

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