Zinc and human immunodeficiency virus infection

Siberry, George K.; Ruff, Andrea; Black, Robert E.

doi:10.1016/s0271-5317(02)00364-0

Cited by 19 publications

(9 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies have shown that HAART improves serum zinc levels probably by reducing viral load, improving general well being, immune status, and invariably, overall nutrition in HIV patients, thus reducing the number of HIV sero-positive children that will be zinc deficient. 13,14 HAART also reduces opportunistic infections, and thus reduces the frequency of repeated infections and excessive utilization of zinc. The higher prevalence of zinc deficiency in HIV seropositive children in this study as against that by Eley et al, can be explained by the fact that the children investigated by Eley et al were clinically stable, and received nutritional rehabilitation, thus improving their macroand micro-nutrient status.…”

Section: Serum Zinc Levels and Hiv Diseasementioning

confidence: 99%

See 1 more Smart Citation

Serum zinc levels in HIV infected children attending the University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria.

Yarhere¹,

Ugwu²,

Eneh³

2014

Nig. J. Paed.

View full text Add to dashboard Cite

Section: Serum Zinc Levels and Hiv Diseasementioning

confidence: 99%

“…6,8,13 Zinc is required for the enzymes (protease and integrase) activities in HIV and as the virus proliferates and disease progresses, the zinc levels in serum decrease. The proliferation also causes release of oxygen free radicals and superoxide dismutase is used to mop up these free radicals to prevent their accumulation to toxic levels.…”

Section: Cd4mentioning

confidence: 99%

Serum zinc levels in HIV infected children attending the University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria.

Yarhere¹,

Ugwu²,

Eneh³

2014

Nig. J. Paed.

View full text Add to dashboard Cite

“…Whether zinc supplements are beneficial and iron supplements harmful for HIV-infected children remains under investigation. 46,47 Availability of a "combined" vitamin preparation or a fortified porridge would simplify treatment and reduce pill count.…”

Section: Micronutrient Supplementation and Nutrition Counselingmentioning

confidence: 99%

Care and Treatment of HIV-Infected Children in Africa

Baets

Bulterys²,

Abrams³

et al. 2007

The Pediatric Infectious Disease Journal

View full text Add to dashboard Cite

More than 90% of pediatric HIV infection occurs in sub-Saharan Africa and 75% of these children currently die before their fifth birthday. Most HIV-infected children in Africa rely on district hospitals for HIV treatment, but insufficient attention has been paid to improving HIV/AIDS care at this level. Considerable confusion exists about optimal use of combination antiretroviral treatment, prophylaxis for opportunistic infections and other rational healthcare interventions that can greatly improve the quality of life for these children. A simple and inexpensive infant HIV diagnostic assay and alternative laboratory markers of pediatric HIV disease progression would be highly beneficial. Routine anthropometric and neurodevelopmental assessments could help guide initiation and monitoring of antiretroviral therapy. Even in the absence of antiretroviral therapy, interventions such as immunizations, provision of micronutrients and nutrition counseling, prevention and treatment of opportunistic as well as endemic infections (such as helminths and malaria) can substantially reduce pediatric HIV-related morbidity and mortality. The need for pain relief, palliative care, counseling and emotional support is often underestimated. Surmounting the sense of hopelessness by providing district healthcare workers with training in basic pediatric HIV/AIDS care is an urgent priority.

show abstract

“…Measurement of zinc levels on a population basis has proved useful; however, individual measurement is difficult to perform, especially in people with chronic inflammatory diseases or infections. 9 Perhaps the most reliable method for diagnosing zinc deficiency is a positive clinical response to supplementation with the element and subsequent reduction in symptoms.…”

Section: Zinc and Developmentmentioning

confidence: 99%