Zinc and Homocysteine Levels in Polycystic Ovarian Syndrome Patients with Insulin Resistance

Güler, İsmail; Himmetoğlu, Özdemir; Turp, Ahmet Berkız; Erdem, Ahmet; Erdem, Mehmet; Onan, Mehmet Anıl; Taskiran, Cagatay; Taşlıpınar, Mine Yavuz; Güner, Haldun

doi:10.1007/s12011-014-9941-7

Cited by 51 publications

(44 citation statements)

References 38 publications

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“…Of those, two were excluded after full text review because they did not focus on the serum levels of trace elements [40,41]. The six articles [42][43][44][45][46][47] that were included in the systematic review presented data on serum or plasma levels of chromium, cobalt, copper, manganese, nickel, selenium, vanadium, and zinc.…”

Section: Discussionmentioning

confidence: 99%

“…Four studies were included in the meta-analysis, totalizing 264 women with PCOS and 151 controls [43,[45][46][47] (Fig. 2).…”

Section: Study Selectionmentioning

confidence: 99%

“…Table 1 describes the characteristics of the six studies included in the systematic review. One study focused on a Chinese population [42], another study on women from India [46], and four on Turkish women [43][44][45]47]. All were casecontrol studies and used the 2003 Rotterdam criteria [2] to diagnose PCOS.…”

Section: Study Selectionmentioning

confidence: 99%

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Blood Trace Element Concentrations in Polycystic Ovary Syndrome: Systematic Review and Meta-analysis

Spritzer

Lecke

Fabris

et al. 2016

Biol Trace Elem Res

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Polycystic ovary syndrome (PCOS) is a prevalent condition in women of reproductive age. PCOS is characterized by androgen excess and chronic anovulation and associated with low-grade inflammation and metabolic comorbidities. Some trace elements have been linked to pathophysiological mechanisms of oxidative stress and inflammation in different disorders. Therefore, we conducted a systematic review and meta-analysis of the available evidence regarding trace element concentrations in PCOS. We reviewed MEDLINE and EMBASE in search of case-control, cross-sectional, and cohort studies published until September 2015. Of 183 studies identified, six were selected for systematic review. All used the Rotterdam criteria for the diagnosis of PCOS. Two studies evaluating chromium and one assessing cobalt levels did not observe differences between PCOS and controls. Another study recorded similar nickel and vanadium levels between the groups, but lower selenium concentrations in women with PCOS compared to controls. Four studies were included in the random effects model meta-analysis, for a total of 264 PCOS and 151 control women. Copper levels were found to be higher in women with PCOS than in controls [mean difference 0.12 ppm (95 % CI 0.07; 0.17 ppm); I 2 = 0 %]. Manganese [mean difference 0.04 ppm (95 % CI −0.05; 0.13 ppm); I 2 = 94.4 %] and zinc concentrations [mean difference 0.02 ppm (95 % CI −0.12; 0.16 ppm); I 2 = 92.4 %] were similar between the groups. The present results suggest a relationship between increased copper concentration and PCOS. This systematic review and meta-analysis is registered in PROSPERO under number CRD42016034036.

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Section: Discussionmentioning

confidence: 99%

“…Four studies were included in the meta-analysis, totalizing 264 women with PCOS and 151 controls [43,[45][46][47] (Fig. 2).…”

Section: Study Selectionmentioning

confidence: 99%

See 1 more Smart Citation

Blood Trace Element Concentrations in Polycystic Ovary Syndrome: Systematic Review and Meta-analysis

Spritzer

Lecke

Fabris

et al. 2016

Biol Trace Elem Res

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“…A deficiency in zinc also increases the risk for hypertension and atherosclerosis. Serum zinc levels have a tendency to be lower in patients with PCOS with impaired glucose tolerance 25 .…”

Section: Discussionmentioning

confidence: 99%

Untitled

2018

IJPSR

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Background:Multiple logistic regression analysis of several metabolic variables between polycystic ovary syndrome and control groups revealed that zinc level was the most important variable to predict polycystic ovarian syndrome. Objective: This study was designed to illustrate the correlation between zinc and copper levels with the biochemical changes associated with polycystic ovary syndrome. Materials and Methods: Twelve women with polycystic ovary syndrome and twelve healthy and normal ovulatory women were included in this study. The serum levels of luteinizing hormone, follicle stimulating hormone, progesterone, testosterone and prolactin were analyzed by enzyme linked immunosorbent assay. Serum zinc and copper was analyzed using atomic absorption spectrophotometer. Student (t) test was performed for comparison and Pearson's correlation coefficients (r) were calculated to quantify the correlation between the biochemical parameters in the study. Results: Both zinc and copper levels showed no significant correlation with other biochemical markers associated with polycystic ovary syndrome. The results revealed an increase in serum zinc concentration in polycystic syndrome group, while it showed no significant difference in copper levels between polycystic ovary syndrome and healthy groups. Conclusion: The study concluded that the rise in zinc level in polycystic ovary syndrome group might be due to the increase in oxidative stress within the body that put the antioxidant defense system in a hyperactive state in order to compensate for this stress.

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“…One of the possible mechanisms of zinc relationship to PCOS other than insulin signaling system defects may be its effect on oxidative stress, zinc is a potent antioxidant and its deficiency causes increased oxidative damage in multiple organs, including the heart (27) .…”

Section: Discussionmentioning

confidence: 99%