Zinc and Diabetes Mellitus Is There a Need of Zinc Supplementation in Diabetes Mellitus Patients?

Abstract

Diabetes mellitus is a group of metabolic disorders, the incidence of which varies widely throughout the world. The treatment of diabetes mellitus includes insulin, oral antidiabetic agents, and dietary regimens. Although the emphasis is on macronutrients intakes, there is strong evidence that there is an abnormal metabolism of several micronutrients in diabetic individuals. Zinc is one of the essential micronutrients of which status and metabolism is altered in this condition. This work is a short review about the close relation among zinc, glucose metabolism, and insulin physiology, as well as about the few experimental data about zinc absorption and zinc supplementation in diabetes mellitus patients.

Metabolic relationship between diabetes and Alzheimer's Disease affected by Cyclo(His-Pro) plus zinc treatment

“…Alzheimer's Disease (AD) and Type 2 Diabetes (T2D) are closely related to each other as both exhibit common metabolic disorders including zinc [90], [91] and insulin degrading enzyme (IDE) deficiencies [30], [35]. Mittal et al [56] has also suggested that AD is a neuroendocrine disorder and that IDE could be the major player which possesses the ability to shift T2D to other metabolic pathways such as regulation of amyloid beta degradation by IDE.…”

Antioxidants status in type 2 diabetic patients in Morocco

“…With Cu, Zn plays an important role in improving the condition of OS state as a cofactor for superoxide dismutase (35). Low values of Zn in diabetic patients can be explained by an alteration of the intestinal absorption of Zn and an increase in urinary excretion, since high concentrations of Zn in urinary secretion are often reported in diabetic patients (36). The Cu/Zn ratios were higher in diabetic patients compared to controls.…”

The vanadium compounds: chemistry, synthesys, insulinomimetic properties

“…Согласно исследованиям последних лет, ряд неорганических соединений, например, соли ванадия [8], молибдена [9], хрома [10], цинка [11] обладают выраженным инсулиномиметическим действием [12][13][14][15]. На данный момент соединения ванадия, которым посвящен обзор, рассматриваются как потенциальные средства, которые позволят уменьшить инсулинорезистентность, не повышая дозу инсулина при СД 1 типа, увеличить чувствительность тканей к инсулину и усилить его эффекты при СД 2 типа.…”