Zinc and diabetes — clinical links and molecular mechanisms

Jansen, J.B.M.J.; Karges, Wölfram; Rink, Lothar

doi:10.1016/j.jnutbio.2009.01.009

Cited by 377 publications

(300 citation statements)

References 228 publications

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“…It localizes to the membrane of the insulin secretory granules, facilitates the accumulation of zinc from the cytoplasm in intracellular insulin-containing vesicles, and plays a major role in providing zinc for insulin maturation and/or storage processes (Chimienti et al, 2006). It was recently shown that SNP rs13266634, located in exon 8 (risk allele C), was associated with T2DM and reduced insulin secretion (Jansen et al, 2009). Although results of these studies remain controversial, there appears to be an association between the risk variant of rs13266634 and reduced insulin secretion (Jansen et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…It was recently shown that SNP rs13266634, located in exon 8 (risk allele C), was associated with T2DM and reduced insulin secretion (Jansen et al, 2009). Although results of these studies remain controversial, there appears to be an association between the risk variant of rs13266634 and reduced insulin secretion (Jansen et al, 2009). This conclusion requires further validations in larger groups.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Association between FTO, MC4R, SLC30A8, and KCNQ1 gene variants and type 2 diabetes in Saudi population

Bazzi¹,

Nasr²,

Alanazi³

et al. 2014

Genet. Mol. Res.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association between FTO, MC4R, SLC30A8, and KCNQ1 gene variants and type 2 diabetes in Saudi population

Bazzi¹,

Nasr²,

Alanazi³

et al. 2014

Genet. Mol. Res.

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“…34 Recently, several genome-wide association studies analyzing the genetic background of diabetes mellitus by genotyping SNPs have found that a nonsynonymous SNP in SLC30A8 (the gene of ZnT8), rs13266634, has frequently been shown to be associated with type 2 diabetes. 35 Taken together, these studies indicate that Zn may importantly maintain the pancreatic islet cell function and as a possible prevention of diabetes; however, more human intervention trials are needed regarding its use in the treatment of diabetes.…”

Section: Zincmentioning

confidence: 95%

Heavy metals, islet function and diabetes development

Lin¹,

Yang²,

Huang³

et al. 2009

Islets

199

131

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“…Zinc is an essential component of numerous proteins, which play crucial roles in growth and development. It showed potent antioxidant and anti-inflammatory properties and was involved in the defence against oxidative stress [8]. Diabetic patients often suffer from zinc deficiency at the late stage, particularly in the patients whose glucose was poorly controlled [9].…”

Section: Introductionmentioning

confidence: 99%

Chard (Beta Vulgaris Var. Cicla) Extract Modulates Zinc Status, Glucose Level and Antioxydant Values in Diabetic Rats Fed Zinc Deficiency Diet

Hamdiken

Kechrid

2017

Int J Pharm Pharm Sci

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Objective: Oxidative stress which comes from hyperglycemia, it accelerates the development of cellular and vascular damage complications in diabetes, but the antioxidants may play a beneficial role in its prevention. Several plants extracts have an antioxidant activity and the ability to reduce oxidative stress in diabetes. Thus this study was conducted to investigate the effect of Beta vulgaris var cicla extract on zinc status, glucose concentration and antioxidant parameters in streptozotocin-diabetic rats fed zinc deficiency diet.Methods: Twenty-eight male albino (Wistar) rats were divided into four groups:Results: Body weight gain of zinc-deficient diabetic animals was lower than that of zinc-adequate diabetic animals. It was noticed also that inadequate dietary zinc intake increased glucose and MDA levels. In addition, zinc deficiency diet led to a decrease in zinc tissues, GSH concentration both GST and GSH-Px activities. However, Oral administration of Beta vulgaris extract significantly decreased both serum glucose and MDA (p<0.001) levels, with a significant increase in body weight gain (p<0.001), GSH concentration (p<0.05, P<0.001), GST (p<0.05, p<0.001) and GSHPx (p<0.001) activities.two groups fed a zinc-sufficient diet one non-diabetic and the other diabetic, while the others two diabetic groups were fed a zinc-deficient diet, one non-treated group and the other treated with the extract of Beta vulgaris var cicla. After 21 d of dietary manipulation, fasting animals were scarified. Blood glucose, tissues zinc (femur, liver, kidney), malondialdehyde (MDA), reduced glutathione (GSH), glutathione peroxidase (GSH-Px) and glutathione-S-transferase (GST) were evaluated. Conclusion:The present study showed that Beta vulgaris var cicla supplementation presumably acting as an antioxidant, and it can be a natural Keywords: Diabetes, Rat, Zinc deficiency, Beta vulgaris var cicla, Antioxidant source for the reduction of diabetes development caused by zinc deficiency.

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Zinc and diabetes — clinical links and molecular mechanisms

Cited by 377 publications

References 228 publications

Association between FTO, MC4R, SLC30A8, and KCNQ1 gene variants and type 2 diabetes in Saudi population

Association between FTO, MC4R, SLC30A8, and KCNQ1 gene variants and type 2 diabetes in Saudi population

Heavy metals, islet function and diabetes development

Chard (Beta Vulgaris Var. Cicla) Extract Modulates Zinc Status, Glucose Level and Antioxydant Values in Diabetic Rats Fed Zinc Deficiency Diet

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